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    Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 19181, updated on 4-May-2024

    Summary

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    Official Symbol
    Psmc2provided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, ATPase 2provided by MGI
    Primary source
    MGI:MGI:109555
    See related
    Ensembl:ENSMUSG00000028932 AllianceGenome:MGI:109555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable TBP-class protein binding activity and proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome accessory complex. Is expressed in genitourinary system. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 61.8), CNS E11.5 (RPKM 44.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psmc2 in Genome Data Viewer
    Location:
    5 A3; 5 9.97 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21990273..22008785)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21785275..21803787)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12576 Neighboring gene predicted gene 15715 Neighboring gene peptidase (mitochondrial processing) beta Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene solute carrier family 26, member 5 Neighboring gene STARR-seq mESC enhancer starr_12580 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene reelin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo. Zhou B, et al. Calcif Tissue Int, 2021 Jul. PMID 33625534
    2. Uptake of pathogenic intracellular bacteria into human and murine macrophages downregulates the eukaryotic 26S protease complex ATPase gene. Schwan WR, et al. Infect Immun, 1997 Nov. PMID 9353061, Free PMC Article
    3. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Gordon C, et al. Nature, 1993 Nov 25. PMID 8247131
    4. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. Borodovsky A, et al. EMBO J, 2001 Sep 17. PMID 11566882, Free PMC Article
    5. Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies. Kratz CP, et al. Genomics, 2001 Oct. PMID 11597142

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.
      Title: Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome accessory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome regulatory subunit 7
    Names
    26S protease regulatory subunit 7
    26S proteasome AAA-ATPase subunit RPT1
    proteasome 26S subunit ATPase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368661.1 → NP_001355590.1  26S proteasome regulatory subunit 7

      Status: VALIDATED

      Source sequence(s)
      AC125313
      Consensus CDS
      CCDS19108.1
      UniProtKB/Swiss-Prot
      O08531, P46471, Q3TGX5, Q9DBA1
      UniProtKB/TrEMBL
      Q3UIH5
      Conserved Domains (1) summary
      COG1222
      Location:23 → 430
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

    2. NM_011188.4 → NP_035318.2  26S proteasome regulatory subunit 7

      Status: VALIDATED

      Source sequence(s)
      AC125313
      Consensus CDS
      CCDS19108.1
      UniProtKB/Swiss-Prot
      O08531, P46471, Q3TGX5, Q9DBA1
      UniProtKB/TrEMBL
      Q3UIH5
      Related
      ENSMUSP00000030769.7, ENSMUST00000030769.7
      Conserved Domains (1) summary
      COG1222
      Location:23 → 430
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21990273..22008785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46471.5 GenPept UniProtKB/Swiss-Prot:P46471

    Gene LinkOut

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