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    pid1 phosphotyrosine interaction domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 541377, updated on 27-Mar-2024

    Summary

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    Official Symbol
    pid1provided by ZNC
    Official Full Name
    phosphotyrosine interaction domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-72
    See related
    Ensembl:ENSDARG00000098984 AllianceGenome:ZFIN:ZDB-GENE-050320-72
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb36h10; zgc:113478
    Summary
    Predicted to be involved in negative regulation of glucose import and regulation of reactive oxygen species metabolic process. Predicted to act upstream of or within negative regulation of insulin receptor signaling pathway; regulation of cell population proliferation; and regulation of mitochondrial membrane potential. Predicted to be active in cytoplasm. Is expressed in several structures, including hypochord; notochord; optic primordium; optic vesicle; and tail bud. Orthologous to human PID1 (phosphotyrosine interaction domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (46634371..46684440, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (46636353..46686472, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909181 Neighboring gene dynein assembly factor with WDR repeat domains 1 Neighboring gene SPHK1 interactor, AKAP domain containing Neighboring gene delta/notch-like EGF repeat containing Neighboring gene uncharacterized LOC103909182

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish. Hsieh FY, et al. Dev Biol, 2013 Mar 1. PMID 23328254
    2. A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Melvin VS, et al. Dev Dyn, 2013 Jul. PMID 23559552, Free PMC Article
    3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of glucose import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of reactive oxygen species metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PTB-containing, cubilin and LRP1-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013504.1 → NP_001013522.1  PTB-containing, cubilin and LRP1-interacting protein

      See identical proteins and their annotated locations for NP_001013522.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091674
      UniProtKB/TrEMBL
      A0A8M1N4P3, Q5BJ04
      Related
      ENSDARP00000138635.1, ENSDART00000167520.2
      Conserved Domains (1) summary
      cd13167
      Location:42 → 183
      PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      46634371..46684440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467644.1 → XP_021323319.1  PTB-containing, cubilin and LRP1-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9PFE7
      Conserved Domains (1) summary
      cd13167
      Location:56 → 197
      PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395049.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      203909..255530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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