Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacng1provided by RGD
Official Full Name: calcium voltage-gated channel auxiliary subunit gamma 1provided by RGD
Primary source: RGD:2249
See related: Ensembl:ENSRNOG00000003245 AllianceGenome:RGD:2249
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cacng
Summary: Enables calcium channel regulator activity. Involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in malignant hyperthermia. Orthologous to human CACNG1 (calcium voltage-gated channel auxiliary subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1296.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (93152558..93165246, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (92652924..92665612, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (95921479..95934170, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sarcoplasmic reticulum calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sarcoplasmic reticulum calcium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of L-type voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of L-type voltage-gated calcium channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of L-type voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in T-tubule	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-dependent calcium channel gamma-1 subunit

Names: calcium channel, voltage-dependent, gamma subunit 1; dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.