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    Cd3d CD3 delta subunit of T-cell receptor complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25710, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cd3dprovided by RGD
    Official Full Name
    CD3 delta subunit of T-cell receptor complexprovided by RGD
    Primary source
    RGD:2304
    See related
    Ensembl:ENSRNOG00000015994 AllianceGenome:RGD:2304
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and positive thymic T cell selection. Predicted to be integral component of membrane. Predicted to be part of alpha-beta T cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 19 and severe combined immunodeficiency. Orthologous to human CD3D (CD3d molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 3195.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54184573..54190112)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45287803..45293342)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49282502..49287095)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitination factor E4A Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A, pseudogene 1 Neighboring gene CD3 gamma subunit of T-cell receptor complex Neighboring gene CD3 epsilon subunit of T-cell receptor complex Neighboring gene myelin protein zero-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Initiation of TCR signaling: regulation within CD3 dimers. Alarcón B, et al. Immunol Rev, 2003 Feb. PMID 12614350
    2. The role of modified purine 64 in initiator/elongator discrimination of tRNA(iMet) from yeast and wheat germ. Kiesewetter S, et al. Nucleic Acids Res, 1990 Aug 25. PMID 2395634, Free PMC Article
    3. Nucleotide sequence of a cDNA encoding the rat T3 delta chain. Davies JD, et al. Nucleic Acids Res, 1990 Aug 11. PMID 2143819, Free PMC Article
    4. Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. Dadi HK, et al. N Engl J Med, 2003 Nov 6. PMID 14602880
    5. Biochemical evidence for the presence of a single CD3delta and CD3gamma chain in the surface T cell receptor/CD3 complex. Pan Q, et al. J Biol Chem, 2004 Dec 3. PMID 15459203

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive thymic T cell selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive thymic T cell selection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of alpha-beta T cell receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha-beta T cell receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of alpha-beta T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD3 delta chain
    Names
    CD3 antigen delta polypeptide
    CD3 molecule delta polypeptide
    CD3 molecule, delta
    CD3d molecule
    T-cell receptor T3 delta chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013169.1 → NP_037301.1  T-cell surface glycoprotein CD3 delta chain precursor

      See identical proteins and their annotated locations for NP_037301.1

      Status: PROVISIONAL

      Source sequence(s)
      X53430
      UniProtKB/Swiss-Prot
      P19377
      UniProtKB/TrEMBL
      A0A8L2QB67, A6J422
      Related
      ENSRNOP00000021489.4, ENSRNOT00000021488.6
      Conserved Domains (2) summary
      pfam02189
      Location:146 → 165
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam16680
      Location:31 → 95
      Ig_4; T-cell surface glycoprotein CD3 delta chain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      54184573..54190112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080903.2 → XP_038936831.1  T-cell surface glycoprotein CD3 delta chain isoform X1

      Conserved Domains (2) summary
      pfam02189
      Location:73 → 92
      ITAM; Immunoreceptor tyrosine-based activation motif
      cl11960
      Location:19 → 31
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19377.1 GenPept UniProtKB/Swiss-Prot:P19377

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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