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    Ube2q1 ubiquitin-conjugating enzyme E2Q family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 70093, updated on 4-May-2024

    Summary

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    Official Symbol
    Ube2q1provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Q family member 1provided by MGI
    Primary source
    MGI:MGI:1917343
    See related
    Ensembl:ENSMUSG00000042572 AllianceGenome:MGI:1917343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtap; Ube2q; NICE-5; PRO3094; 1110002C01Rik; 2310012M18Rik
    Summary
    Enables ubiquitin conjugating enzyme activity. Acts upstream of or within several processes, including embryo implantation; prolactin secretion; and suckling behavior. Predicted to be located in cell projection and cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including 4-cell stage embryo; blastocyst; mammary gland; reproductive system; and spleen. Orthologous to human UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 15.4), CNS E11.5 (RPKM 14.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 39.19 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89680905..89691304)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89773609..89783997)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene adenosine deaminase, RNA-specific Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene RIKEN cDNA 4632404H12 gene Neighboring gene STARR-positive B cell enhancer ABC_E2082 Neighboring gene STARR-seq mESC enhancer starr_08252 Neighboring gene STARR-seq mESC enhancer starr_08253 Neighboring gene STARR-positive B cell enhancer ABC_E2083 Neighboring gene STARR-seq mESC enhancer starr_08257 Neighboring gene predicted gene 8969 Neighboring gene src homology 2 domain-containing transforming protein E Neighboring gene STARR-positive B cell enhancer ABC_E9217

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice. Grzmil P, et al. Reproduction, 2013 Jan. PMID 23108111
    2. Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. Wassler MJ, et al. Stem Cells, 2008 Aug. PMID 18511602
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ube2q1 is not expressed in the uterus of non-pregnant females but its expression is up-regulated during pregnancy. Ube2q1 is involved in different aspects of female fertility.
      Title: Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice.
    2. GTAP functions as an evolutionarily conserved E2 enzyme, which may participate in intercellular adhesion and embryonic development.
      Title: Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within prolactin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within reproductive system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within suckling behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 Q1
    Names
    E2 ubiquitin-conjugating enzyme Q1
    galactosyl transferase-associated protein
    ubiquitin carrier protein Q1
    ubiquitin-conjugating enzyme E2Q (putative) 1
    ubiquitin-protein ligase Q1
    NP_081591.3
    XP_036019192.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027315.4 → NP_081591.3  ubiquitin-conjugating enzyme E2 Q1

      See identical proteins and their annotated locations for NP_081591.3

      Status: VALIDATED

      Source sequence(s)
      AC102392
      Consensus CDS
      CCDS17517.1
      UniProtKB/Swiss-Prot
      Q29ST1, Q3UIY3, Q6P913, Q7TSS2, Q80UT5, Q8K2T0, Q9D7E1
      Related
      ENSMUSP00000037939.9, ENSMUST00000038356.13
      Conserved Domains (1) summary
      cd00195
      Location:253 → 409
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89680905..89691304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163299.1 → XP_036019192.1  ubiquitin-conjugating enzyme E2 Q1 isoform X1

      Related
      ENSMUSP00000143422.2, ENSMUST00000196726.2
      Conserved Domains (1) summary
      cd00195
      Location:84 → 240
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSS2.2 GenPept UniProtKB/Swiss-Prot:Q7TSS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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