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    Dync2i2 dynein 2 intermediate chain 2 [ Mus musculus (house mouse) ]

    Gene ID: 71820, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dync2i2provided by MGI
    Official Full Name
    dynein 2 intermediate chain 2provided by MGI
    Primary source
    MGI:MGI:1919070
    See related
    Ensembl:ENSMUSG00000039715 AllianceGenome:MGI:1919070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr34; 3200002I06Rik
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in cilium assembly and intraciliary retrograde transport. Located in cytoskeleton and filopodium. Part of cytoplasmic dynein complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 29.0), testis adult (RPKM 27.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 21.04 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29921563..29938891, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30031551..30048879, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4425 Neighboring gene GLE1 RNA export mediator Neighboring gene STARR-seq mESC enhancer starr_04079 Neighboring gene STARR-seq mESC enhancer starr_04080 Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene microRNA 6997 Neighboring gene STARR-seq mESC enhancer starr_04082 Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene SET nuclear oncogene Neighboring gene protein kinase N3 Neighboring gene zinc finger, DHHC domain containing 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy. Schmidts M, et al. Am J Hum Genet, 2013 Nov 7. PMID 24183451, Free PMC Article
    2. Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse. Wu C, et al. Hum Mol Genet, 2017 Jul 1. PMID 28379358, Free PMC Article
    3. Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos. Yan L, et al. Front Cell Dev Biol, 2023. PMID 37228654, Free PMC Article
    4. ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Goggolidou P, et al. Development, 2014 Oct. PMID 25294941, Free PMC Article
    5. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103259

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary retrograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intraciliary retrograde transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary plasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoplasmic dynein 2 intermediate chain 2
    Names
    WD repeat domain 34
    WD repeat-containing protein 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008498.2 → NP_001008498.2  cytoplasmic dynein 2 intermediate chain 2

      See identical proteins and their annotated locations for NP_001008498.2

      Status: VALIDATED

      Source sequence(s)
      BC085113, BX005298
      Consensus CDS
      CCDS15865.2
      UniProtKB/Swiss-Prot
      A2BE91, Q5U4F6
      Related
      ENSMUSP00000109340.3, ENSMUST00000113711.3
      Conserved Domains (2) summary
      COG2319
      Location:101 → 515
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:223 → 265
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29921563..29938891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U4F6.3 GenPept UniProtKB/Swiss-Prot:Q5U4F6

    Gene LinkOut

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