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    Gnb3 G protein subunit beta 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60449, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gnb3provided by RGD
    Official Full Name
    G protein subunit beta 3provided by RGD
    Primary source
    RGD:708344
    See related
    Ensembl:ENSRNOG00000015541 AllianceGenome:RGD:708344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg2d
    Summary
    Enables spectrin binding activity. Predicted to be involved in several processes, including cell volume homeostasis; regulation of fat cell differentiation; and regulation of lipid metabolic process. Located in cell body and neuron projection. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 131.2), Thymus (RPKM 14.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159325741..159331443, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157639468..157645171, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157352558..157359237, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene cell division cycle associated 3 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene uncharacterized LOC120102385 Neighboring gene G protein-coupled receptor 162

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. Jacobi J, et al. J Hypertens, 1999 Oct. PMID 10526907
    2. Cloning and sequencing of a rat heart cDNA encoding a G-protein beta subunit related to the human retinal beta 3 subunit. Ray K, et al. Gene, 1994 Nov 18. PMID 7959013
    3. GNB3 overexpression causes obesity and metabolic syndrome. Ozdemir AC, et al. PLoS One, 2017. PMID 29206867, Free PMC Article
    4. Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM. Daimon M, et al. Biochem Biophys Res Commun, 2008 Sep 26. PMID 18656447
    5. Association of the C825T polymorphism of the G-protein beta3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese. Hayakawa T, et al. Metabolism, 2007 Jan. PMID 17161225

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105437

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of locomotion involved in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
    Names
    G protein beta-subunit
    guanine nucleotide binding protein (G protein), beta 3
    guanine nucleotide binding protein (G protein), beta polypeptide 3
    guanine nucleotide binding protein, beta 3
    guanine nucleotide-binding protein, beta-3 subunit
    heterotrimeric guanine nucleotide-binding protein 2d
    transducin beta chain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021858.3 → NP_068630.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

      See identical proteins and their annotated locations for NP_068630.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086422
      UniProtKB/Swiss-Prot
      P52287
      UniProtKB/TrEMBL
      A6ILM1, Q45QL4
      Related
      ENSRNOP00000021480.3, ENSRNOT00000021481.5
      Conserved Domains (2) summary
      cd00200
      Location:48 → 340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 95
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159325741..159331443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52287.1 GenPept UniProtKB/Swiss-Prot:P52287

    Gene LinkOut

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