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    Mrgpre MAS-related GPR, member E [ Mus musculus (house mouse) ]

    Gene ID: 244238, updated on 8-May-2024

    Summary

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    Official Symbol
    Mrgpreprovided by MGI
    Official Full Name
    MAS-related GPR, member Eprovided by MGI
    Primary source
    MGI:MGI:2441884
    See related
    Ensembl:ENSMUSG00000048965 AllianceGenome:MGI:2441884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mgrf; MrgE; Ebrt3; C130069N09Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; cartilage; eye; genitourinary system; and nervous system. Orthologous to human MRGPRE (MAS related GPR family member E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 3.2), CNS E18 (RPKM 3.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrgpre in Genome Data Viewer
    Location:
    7 F5; 7 88.31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143332100..143338237, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143778363..143784500, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 5 Neighboring gene STARR-positive B cell enhancer ABC_E2256 Neighboring gene STARR-positive B cell enhancer ABC_E3762 Neighboring gene MAS-related GPR, member G Neighboring gene NAD synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1750 Neighboring gene STARR-positive B cell enhancer ABC_E2257 Neighboring gene STARR-positive B cell enhancer ABC_E3763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:151023918-151024190 Neighboring gene 7-dehydrocholesterol reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mas-related G protein-coupled receptor D is involved in modulation of murine gastrointestinal motility. Xu M, et al. Exp Physiol, 2021 Dec. PMID 34647371
    2. The effect of deletion of the orphan G - protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice. Cox PJ, et al. Mol Pain, 2008 Jan 15. PMID 18197975, Free PMC Article
    3. The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum. Avula LR, et al. Histochem Cell Biol, 2011 Nov. PMID 21912971
    4. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Han SK, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12397184, Free PMC Article
    5. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mas-related G protein-coupled receptor D is involved in modulation of murine gastrointestinal motility.
      Title: Mas-related G protein-coupled receptor D is involved in modulation of murine gastrointestinal motility.
    2. The number of enteric neurons expressing MrgE and MrgF receptors was significantly reduced during intestinal schistosomiasis and ileitis.
      Title: The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum.
    3. The data suggests that MrgE may play a role in selective pain behavioural responses in mice.
      Title: The effect of deletion of the orphan G - protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member E
    Names
    G protein-coupled receptor MrgE
    Mas-related G protein-coupled receptor f
    evolutionary breakpoint transcript 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175534.3 → NP_780743.1  mas-related G-protein coupled receptor member E

      See identical proteins and their annotated locations for NP_780743.1

      Status: VALIDATED

      Source sequence(s)
      AJ320231, AK133657, CD807098
      Consensus CDS
      CCDS22046.1
      UniProtKB/Swiss-Prot
      Q711I9, Q91ZB7
      UniProtKB/TrEMBL
      Q4V9R2
      Related
      ENSMUSP00000058000.9, ENSMUST00000054048.10
      Conserved Domains (1) summary
      cd15112
      Location:43 → 292
      7tmA_MrgprE; mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143332100..143338237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153126.1 → XP_036009019.1  mas-related G-protein coupled receptor member E isoform X1

      UniProtKB/Swiss-Prot
      Q711I9, Q91ZB7
      UniProtKB/TrEMBL
      Q4V9R2
      Conserved Domains (1) summary
      cd15112
      Location:43 → 292
      7tmA_MrgprE; mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZB7.1 GenPept UniProtKB/Swiss-Prot:Q91ZB7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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