ywhag1 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ywhag1provided by ZNC
Official Full Name: 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-011115-1
See related: Ensembl:ENSDARG00000067626 AllianceGenome:ZFIN:ZDB-GENE-011115-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb47; ywhag; fd20c02; zgc:73131; wu:fd20c02; wu:fj53d01
Summary: Predicted to enable protein kinase C binding activity. Acts upstream of or within brain development and heart development. Predicted to be active in cytoplasm. Is expressed in head; nervous system; neural tube; otic vesicle; and trigeminal placode. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 56. Orthologous to human YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (3501857..3546601)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (3172125..3216869)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

When zebrafish ywhag1 was knocked down, reduced brain size and increased diameter of the heart tube were observed, indicating that the infantile spasms and cardiomegaly seen in the patient with the telomeric deletion
Title: Zebrafish gene knockdowns imply roles for human YWHAG in infantile spasms and cardiomegaly.

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General gene information

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Markers

fj53d01.x1 (e-PCR)
- UniSTS:199527

fk34a11.y1 (e-PCR)
- UniSTS:200859

fk34h09.x1 (e-PCR)
- UniSTS:200877

fj58d12.x1 (e-PCR)
- UniSTS:199616

AI722187.BR90 (e-PCR)
- UniSTS:206022

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphoserine residue binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein sequestering activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 14-3-3 protein gamma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.