Slc23a2 solute carrier family 23 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc23a2provided by RGD
Official Full Name: solute carrier family 23 member 2provided by RGD
Primary source: RGD:619876
See related: Ensembl:ENSRNOG00000021262 AllianceGenome:RGD:619876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SVCT2
Summary: Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in several processes, including L-ascorbic acid transmembrane transport; cellular response to ethanol; and positive regulation of dendrite extension. Located in basal plasma membrane and cytoplasm. Is integral component of plasma membrane. Orthologous to human SLC23A2 (solute carrier family 23 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 428.3), Brain (RPKM 104.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (139755583..139913304, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (119302651..119395289, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (124632491..124842225, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SVCT2 is heterogeneously induced in reactive astrogliosis generated in different pathologies affecting the central nervous system.
Title: SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies.
We speculate that SVCT2, possibly regulated by JNK/p38 MAPKs, NF-kappaB signaling and miR-125a-5p, has a neuroprotective effect against EtOH-induced oxidative stress. Promotion of SVCT2 expression or stimulation of SVCT2 activity may be a promising therapeutic strategy for the prevention of EtOH-associated neurodegeneration.
Title: SVCT2, a potential therapeutic target, protects against oxidative stress during ethanol-induced neurotoxicity via JNK/p38 MAPKs, NF-κB and miRNA125a-5p.
Expression of SVCT2 was upregulated in neurons after middle cerebral artery occlusion and reperfusion in the nondiabetic cortex, accompanied by an increase in total ascorbic acid in the tissue, and these responses were suppressed in the diabetic rats.
Title: Orally administrated ascorbic acid suppresses neuronal damage and modifies expression of SVCT2 and GLUT1 in the brain of diabetic rats with cerebral ischemia-reperfusion.
metabolic/oxidative stress in the liver induce different responses in the expression of ascorbic acid transporters SVCT1 and SVCT2 in intrahepatic and extrahepatic tissues, which may affect the overall bioavailability and cellular uptake of this vitamin
Title: Liver metabolic/oxidative stress induces hepatic and extrahepatic changes in the expression of the vitamin C transporters SVCT1 and SVCT2.
Expression and localization of sodium-dependent vitamin C transporter-2 in the sarcolemma is reduced by doxorubicin, a change blunted by vitamin C supplementation.
Title: Downregulation of vitamin C transporter SVCT-2 in doxorubicin-induced cardiomyocyte injury.
glutathione depletion failed to affect ascorbic acid transport, and SVCT1 and SVCT2 expression in hepatoma cells.
Title: Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
In adult rats, when obstructive cholestasis was maintained for 8 weeks, a significant up-regulation of Slc23a2 accompanied by a down-regulation of Slc23a1 was found.
Title: Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases.
Results suggest that reduced expression level of sodium-dependent vitamin C transporter type-2 might be involved in the development of morphine side effects such as tolerance and dependency.
Title: Effect of chronic administration of morphine on the gene expression level of sodium-dependent vitamin C transporters in rat hippocampus and lumbar spinal cord.
Analysis of SVCT messenger RNA (mRNA) levels shows that one isoform of this transport protein, SVCT1, declines 45% with age, with no significant changes in SVCT2 mRNA levels.
Title: Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.
mRNA expression patterns of SVCT2 and the glutamate-activated immediate early gene Arc were investigated at 2 and 22 h after middle cerebral artery ischemia in rat brain
Title: Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-ascorbate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-ascorbate:sodium symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-ascorbate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables L-ascorbate:sodium symporter activity	TAS Traceable Author Statement more info	PubMed
enables L-ascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-ascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-ascorbic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-ascorbic acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-ascorbic acid transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-ascorbic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in blood circulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within carboxylic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within monosaccharide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 23 member 2

Names: Na(+)/L-ascorbic acid transporter 2; sodium-coupled ascorbic acid transporter 2; sodium-dependent vitamin C transporter 2; solute carrier family 23 (ascorbic acid transporter), member 2; solute carrier family 23 (nucleobase transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017316.2 → NP_059012.2 solute carrier family 23 member 2

See identical proteins and their annotated locations for NP_059012.2

Status: VALIDATED

Source sequence(s)

AA964954, AF080453, JAXUCZ010000003

UniProtKB/Swiss-Prot

Q9WTW8

UniProtKB/TrEMBL

A6HQF4

Conserved Domains (1) summary

pfam00860
Location:102 → 528

Xan_ur_permease; Permease family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

139755583..139913304 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284409.1 → XP_063140479.1 solute carrier family 23 member 2 isoform X1

UniProtKB/Swiss-Prot

Q9WTW8

UniProtKB/TrEMBL

A6HQF4
XM_006235068.5 → XP_006235130.1 solute carrier family 23 member 2 isoform X1

See identical proteins and their annotated locations for XP_006235130.1

UniProtKB/Swiss-Prot

Q9WTW8

UniProtKB/TrEMBL

A6HQF4

Related

ENSRNOP00000028885.2

Conserved Domains (1) summary

pfam00860
Location:102 → 528

Xan_ur_permease; Permease family
XM_039105735.2 → XP_038961663.1 solute carrier family 23 member 2 isoform X1

UniProtKB/Swiss-Prot

Q9WTW8

UniProtKB/TrEMBL

A6HQF4

Conserved Domains (1) summary

pfam00860
Location:102 → 528

Xan_ur_permease; Permease family
XM_006235067.5 → XP_006235129.1 solute carrier family 23 member 2 isoform X1

See identical proteins and their annotated locations for XP_006235129.1

UniProtKB/Swiss-Prot

Q9WTW8

UniProtKB/TrEMBL

A6HQF4

Conserved Domains (1) summary

pfam00860
Location:102 → 528

Xan_ur_permease; Permease family
XM_063284411.1 → XP_063140481.1 solute carrier family 23 member 2 isoform X2
XM_063284412.1 → XP_063140482.1 solute carrier family 23 member 2 isoform X3
XM_039105736.1 → XP_038961664.1 solute carrier family 23 member 2 isoform X5

Conserved Domains (1) summary

cl23746
Location:85 → 155

Xan_ur_permease; Permease family
XM_063284413.1 → XP_063140483.1 solute carrier family 23 member 2 isoform X4