Kpna1 karyopherin subunit alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kpna1provided by MGI
Official Full Name: karyopherin subunit alpha 1provided by MGI
Primary source: MGI:MGI:103560
See related: Ensembl:ENSMUSG00000022905 AllianceGenome:MGI:103560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NPI1; Rch2; IPOA5; mSRP1
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including NLS-bearing protein import into nucleus; satellite cell activation involved in skeletal muscle regeneration; and skeletal muscle satellite cell proliferation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; gut; integumental system; and sensory organ. Orthologous to human KPNA1 (karyopherin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 11.6), cortex adult (RPKM 11.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 25.43 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (35803693..35859479)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (35983288..36037136)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Importin alpha1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice.
Title: Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice.
Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Title: Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
importin alpha5 influences sphingosine-sensitive anxiety pathways by regulating MeCP2 nuclear import in hippocampal neurons.
Title: Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.
HIV-1 Tat:nuclear localisation signal/cell penetrating peptide is able to form a stable and direct interaction with the classical nuclear import receptor importin-alpha.
Title: Structural Basis for Importin-α Binding of the Human Immunodeficiency Virus Tat.
Importin alpha1 is specifically required for the nuclear localization of several important HSV1 proteins, capsid assembly, and capsid egress into the cytoplasm, and may become rate limiting in situ upon infection at low multiplicity or in terminally differentiated cells such as neurons.
Title: Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.
KPNA1 regulates satellite cell proliferation and survival by modulating nuclear import.
Title: Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import.
mTOR and protein phosphatase 2A catalytically control the constitutive nuclear import of latent STAT1 by KPNA1, which are key modulators of STAT1 expression and apoptosis.
Title: Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin.
KPNA1 knockdown increased myoblast proliferation.
Title: Distinct roles for classical nuclear import receptors in the growth of multinucleated muscle cells.
Absence of importin a5 during mouse development does not significantly interfere with neuronal differentiation and brain development.
Title: Normal brain development in importin-alpha5 deficient-mice.
Importin alpha binding and the nuclear import of myopodin are regulated by the serine/threonine phosphorylation-dependent binding of myopodin to 14-3-3. These results establish a novel paradigm for the promotion of nuclear import by 14-3-3 binding.
Title: Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kpna1 (e-PCR), detects polymorphism
- UniSTS:257078

RH127106 (e-PCR)
- UniSTS:209213

RH126201 (e-PCR)
- UniSTS:162909

Kpna1 (e-PCR), detects polymorphism
- UniSTS:143720

AW494490 (e-PCR)
- UniSTS:180902

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NLS-bearing protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within satellite cell activation involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IC Inferred by Curator more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: importin subunit alpha-5

Names: NPI-1; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin alpha-S1; importin subunit alpha-1; karyopherin (importin) alpha 1; m-importin-alpha-S1; nucleoprotein interactor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416718.1 → NP_001403647.1 importin subunit alpha-5 isoform 1

Status: VALIDATED

Source sequence(s)

AC133464, CT573031

UniProtKB/Swiss-Prot

Q3TF32, Q60960
NM_001416721.1 → NP_001403650.1 importin subunit alpha-5 isoform 2

Status: VALIDATED

Source sequence(s)

AC133464, CT573031
NM_001416723.1 → NP_001403652.1 importin subunit alpha-5 isoform 2

Status: VALIDATED

Source sequence(s)

AC133464, CT573031
NM_001416724.1 → NP_001403653.1 importin subunit alpha-5 isoform 2

Status: VALIDATED

Source sequence(s)

AC133464, CT573031
NM_001416725.1 → NP_001403654.1 importin subunit alpha-5 isoform 2

Status: VALIDATED

Source sequence(s)

AC133464, CT573031
NM_008465.6 → NP_032491.2 importin subunit alpha-5 isoform 1

See identical proteins and their annotated locations for NP_032491.2

Status: VALIDATED

Source sequence(s)

AC133464, CT573031

Consensus CDS

CCDS28144.1

UniProtKB/Swiss-Prot

Q3TF32, Q60960

Related

ENSMUSP00000004054.7, ENSMUST00000004054.13

Conserved Domains (2) summary

COG5064
Location:33 → 516

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:128 → 154

ARM; armadillo repeat [structural motif]