Ckb creatine kinase, brain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ckbprovided by MGI
Official Full Name: creatine kinase, brainprovided by MGI
Primary source: MGI:MGI:88407
See related: Ensembl:ENSMUSG00000001270 AllianceGenome:MGI:88407
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bck; Ck3; B-CK; Ck-3; Ckbb; CPK-B
Summary: Enables creatine kinase activity. Predicted to be involved in cellular chloride ion homeostasis and phosphocreatine biosynthetic process. Located in myelin sheath. Is active in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Orthologous to human CKB (creatine kinase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 1178.4), frontal lobe adult (RPKM 855.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 61.09 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (111635789..111638772, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (111669355..111672338, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.
Title: Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.
Title: Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.
Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B.
Title: Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B.
Creatine kinase B controls futile creatine cycling in thermogenic fat.
Title: Creatine kinase B controls futile creatine cycling in thermogenic fat.
Loss of normal CKB structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse.
Title: Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.
CKB plays a key role in myotube formation by limiting myoblast fusion during myogenesis.
Title: Creatine kinase B is necessary to limit myoblast fusion during myogenesis.
BCK phosphorylation at Ser6 did not affect its enzymatic activity, but led to the appearance of the phosphorylated enzyme at the endoplasmic reticulum (ER)
Title: Regulation of brain-type creatine kinase by AMP-activated protein kinase: interaction, phosphorylation and ER localization.
Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation
Title: Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation.
negative regulation of CKB by mHTT is a key event in the pathogenesis of HD and contributes to the neuronal dysfunction associated with HD.
Title: Enhancement of brain-type creatine kinase activity ameliorates neuronal deficits in Huntington's disease.
reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment
Title: Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ckb (e-PCR), detects polymorphism
- UniSTS:141343

Ckb (e-PCR), detects polymorphism
- UniSTS:141344

Ckb (e-PCR), detects polymorphism
- UniSTS:472872

D6Wox13 (e-PCR)
- UniSTS:118104

MARC_6785-6786:992007454:1 (e-PCR)
- UniSTS:231270

RH127492 (e-PCR)
- UniSTS:210802

Egfr-rs (e-PCR), detects polymorphism
- UniSTS:142973

NoName (e-PCR)
- UniSTS:546700

Ckb (e-PCR), detects polymorphism
- UniSTS:546700

D1S3693 (e-PCR)
- UniSTS:474271

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables creatine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in futile creatine cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphocreatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: creatine kinase B-type

Names: creatine kinase B chain; creatine phosphokinase B-type

NP_067248.1

EC 2.7.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.