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    S1pr4 sphingosine-1-phosphate receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 13611, updated on 30-Apr-2024

    Summary

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    Official Symbol
    S1pr4provided by MGI
    Official Full Name
    sphingosine-1-phosphate receptor 4provided by MGI
    Primary source
    MGI:MGI:1333809
    See related
    Ensembl:ENSMUSG00000044199 AllianceGenome:MGI:1333809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Edg6; Lpc1; S1p4
    Summary
    This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010]
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81333579..81335971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81497745..81500137, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CUGBP, Elav-like family member 5 Neighboring gene STARR-seq mESC enhancer starr_27338 Neighboring gene nicalin Neighboring gene STARR-positive B cell enhancer ABC_E8350 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80973115-80973298 Neighboring gene guanine nucleotide binding protein, alpha 15 Neighboring gene STARR-positive B cell enhancer ABC_E11449 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80989510-80989711 Neighboring gene guanine nucleotide binding protein, alpha 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation. Wang S, et al. Int J Biol Sci, 2023. PMID 37056936, Free PMC Article
    2. S1PR(4) deficiency results in reduced germinal center formation but only marginally affects antibody production. Riese J, et al. Front Immunol, 2022. PMID 36532028, Free PMC Article
    3. Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype. Hansen L, et al. J Neurosci, 2022 Mar 9. PMID 34903569, Free PMC Article
    4. Sphingosine-1-Phosphate Receptor Type 4 (S1P(4)) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions. Riese J, et al. Int J Mol Sci, 2021 Mar 27. PMID 33801658, Free PMC Article
    5. S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells. Kulinski JM, et al. Int J Mol Sci, 2018 Apr 25. PMID 29693558, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.
      Title: Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.
    2. Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
      Title: Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
    3. Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome.
      Title: Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome.
    4. Sphingosine-1-Phosphate Receptor Type 4 (S1P4) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions.
      Title: Sphingosine-1-Phosphate Receptor Type 4 (S1P(4)) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions.
    5. S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.
      Title: S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.
    6. S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model.
      Title: S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model.
    7. Genetic deletion of S1pr4 resulted in exacerbation of passive systemic anaphylaxis to IgE/anti-IgE.
      Title: S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells.
    8. Data shows a reduced abundance of pDC, particularly CD4- pDC, in all organs of S1PR4-deficient vs. wildtype mice.
      Title: S1PR4 is required for plasmacytoid dendritic cell differentiation.
    9. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists
      Title: Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists.
    10. S1P4 signaling is involved in the regulation of dendritic cell function and TH17 T-cell differentiation. S1P4-mediated S1P signaling also modifies the course of various immune diseases in a murine model
      Title: Sphingosine-1-phospate receptor 4 (S1P₄) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129298

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables sphingosine-1-phosphate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingosine 1-phosphate receptor 4
    Names
    S1P receptor Edg-6
    S1p receptor 4
    endothelial differentiation G-protein-coupled receptor 6
    lysophospholipid receptor C1
    sphingosine 1-phosphate receptor Edg-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010102.2 → NP_034232.1  sphingosine 1-phosphate receptor 4

      See identical proteins and their annotated locations for NP_034232.1

      Status: REVIEWED

      Source sequence(s)
      AC159474
      Consensus CDS
      CCDS24059.1
      UniProtKB/Swiss-Prot
      Q3U4H3, Q8C6E2, Q8K1R9, Q9Z0L1
      Related
      ENSMUSP00000050412.6, ENSMUST00000053646.7
      Conserved Domains (2) summary
      cd14964
      Location:52 → 76
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:51 → 320
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81333579..81335971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0L1.1 GenPept UniProtKB/Swiss-Prot:Q9Z0L1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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