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    Desi2 desumoylating isopeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 78825, updated on 20-Apr-2024

    Summary

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    Official Symbol
    Desi2provided by MGI
    Official Full Name
    desumoylating isopeptidase 2provided by MGI
    Primary source
    MGI:MGI:1926075
    See related
    Ensembl:ENSMUSG00000026502 AllianceGenome:MGI:1926075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DeSI-2; Pppde1; Fam152a; 5830417C01Rik
    Summary
    Predicted to enable Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; muscle tissue; and spleen. Orthologous to human DESI2 (desumoylating isopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.4), bladder adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H4; 1 82.93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178014983..178080164)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178187417..178252598)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit epsilon 2 Neighboring gene predicted gene, 25312 Neighboring gene STARR-seq mESC enhancer starr_03139 Neighboring gene STARR-positive B cell enhancer ABC_E4396 Neighboring gene translin-associated factor X pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:180115890-180116191 Neighboring gene STARR-positive B cell enhancer ABC_E2023 Neighboring gene STARR-seq mESC enhancer starr_03140 Neighboring gene STARR-positive B cell enhancer mm9_chr1:180172365-180172665 Neighboring gene RIKEN cDNA 4930527J03 gene Neighboring gene STARR-seq mESC enhancer starr_03141 Neighboring gene predicted gene 8023

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comprehensive analysis of expression profile reveals the ubiquitous distribution of PPPDE peptidase domain 1, a Golgi apparatus component, and its implications in clinical cancer. He Y, et al. Biochimie, 2013 Jul. PMID 23567336
    2. PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain. Cai P, et al. Mol Biol Rep, 2012 Jan. PMID 21553223
    3. A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice. Yan F, et al. Biochimie, 2009 Apr. PMID 19133312
    4. DeSUMOylating isopeptidase: a second class of SUMO protease. Shin EJ, et al. EMBO Rep, 2012 Apr. PMID 22370726, Free PMC Article
    5. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett, 2000 Apr 28. PMID 10788617

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression regulation and biological functions of PPPDE1 in development and carcinogenesis.
      Title: Comprehensive analysis of expression profile reveals the ubiquitous distribution of PPPDE peptidase domain 1, a Golgi apparatus component, and its implications in clinical cancer.
    2. PNAS4 was not involved in mice brain development and apoptosis.
      Title: PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain.
    3. overexpression of mouse PNAS4 significantly suppressed Lewis lung carcinoma growth and prolonged survival time through induction of tumor cell apoptosis
      Title: A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • DKFZp586C1019

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deubiquitinase DESI2
    Names
    PPPDE peptidase domain containing 1
    PPPDE peptidase domain-containing protein 1
    S-depalmitoylase DESI2
    family with sequence similarity 152, member A
    palmitoyl protein thioesterase DESI2
    NP_077244.1
    XP_030099574.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024282.3 → NP_077244.1  deubiquitinase DESI2

      See identical proteins and their annotated locations for NP_077244.1

      Status: VALIDATED

      Source sequence(s)
      AC119928, AK029574, AK049579
      Consensus CDS
      CCDS35803.1
      UniProtKB/Swiss-Prot
      Q3TUJ4, Q9D291
      UniProtKB/TrEMBL
      Q3UJE4
      Related
      ENSMUSP00000027783.8, ENSMUST00000027783.14
      Conserved Domains (1) summary
      pfam05903
      Location:7 → 149
      Peptidase_C97; PPPDE putative peptidase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      178014983..178080164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243714.2 → XP_030099574.1  deubiquitinase DESI2 isoform X1

      UniProtKB/TrEMBL
      Q3UJE4, Q8BIB9
      Related
      ENSMUSP00000124658.2, ENSMUST00000161075.8
      Conserved Domains (1) summary
      pfam05903
      Location:4 → 133
      Peptidase_C97; PPPDE putative peptidase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D291.1 GenPept UniProtKB/Swiss-Prot:Q9D291

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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