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    herpud2 HERPUD family member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 393157, updated on 27-Mar-2024

    Summary

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    Official Symbol
    herpud2provided by ZNC
    Official Full Name
    HERPUD family member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-868
    See related
    Ensembl:ENSDARG00000021033 AllianceGenome:ZFIN:ZDB-GENE-040426-868
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56020; zgc:76968
    Summary
    Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human HERPUD2 (HERPUD family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (42481418..42494345)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (42577717..42590587)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:ch211-215k15.4 Neighboring gene protein kinase-like domain containing Neighboring gene T-box transcription factor 20 Neighboring gene dpy-19-like 1, like (H. sapiens)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. Just S, et al. PLoS One, 2016. PMID 27907103, Free PMC Article
    2. PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Gao H, et al. Hum Mol Genet, 2010 Jan 1. PMID 19801576
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRKCSH functions as a chaperone-like molecule, which prevents endoplasmic reticulum-associated degradation of TRPP2.
      Title: PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56020

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200188.1 → NP_956482.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

      See identical proteins and their annotated locations for NP_956482.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045865
      UniProtKB/Swiss-Prot
      Q6NYI0, Q7ZVH0
      Related
      ENSDARP00000038769.6, ENSDART00000037401.7
      Conserved Domains (2) summary
      cd01790
      Location:9 → 87
      Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
      smart00213
      Location:10 → 87
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      42481418..42494345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466640.1 → XP_021322315.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X1

      UniProtKB/Swiss-Prot
      Q6NYI0, Q7ZVH0
      UniProtKB/TrEMBL
      A0A8M9PM99
      Conserved Domains (1) summary
      cd01790
      Location:9 → 87
      Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NYI0.1 GenPept UniProtKB/Swiss-Prot:Q6NYI0

    Gene LinkOut

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