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    Cd72 CD72 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12517, updated on 21-May-2024

    Summary

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    Official Symbol
    Cd72provided by MGI
    Official Full Name
    CD72 antigenprovided by MGI
    Primary source
    MGI:MGI:88345
    See related
    Ensembl:ENSMUSG00000028459 AllianceGenome:MGI:88345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD72c; Ly-19; Ly-32; Lyb-2; Ly-m19
    Summary
    Predicted to enable carbohydrate binding activity and transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; cerebellum external granule cell layer; cerebellum internal granule cell layer; hippocampus; and neocortex. Orthologous to human CD72 (CD72 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 30.9), testis adult (RPKM 10.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd72 in Genome Data Viewer
    Location:
    4 A5; 4 23.04 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43447724..43454708, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43447724..43455102, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 2 Neighboring gene predicted gene, 52698 Neighboring gene STARR-seq mESC enhancer starr_10053 Neighboring gene ciliary microtubule inner protein 2B Neighboring gene testis specific protein kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2109 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:43495064-43495217 Neighboring gene STARR-positive B cell enhancer ABC_E834 Neighboring gene suppression inducing transmembrane adaptor 1 Neighboring gene RNA component of mitochondrial RNAase P

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Modulation of peripheral B cell tolerance by CD72 in a murine model. Li DH, et al. Arthritis Rheum, 2008 Oct. PMID 18821699, Free PMC Article
    2. CD72 down-modulates BCR-induced signal transduction and diminishes survival in primary mature B lymphocytes. Li DH, et al. J Immunol, 2006 May 1. PMID 16621999
    3. Dual regulation of BCR-mediated growth inhibition signaling by CD72. Baba T, et al. Eur J Immunol, 2005 May. PMID 15816000
    4. Partial cDNA sequences of bovine CD72 and CD166/ALCAM, ligands for SRCR-family accessory molecules CD5 and CD6. Rogers AN, et al. Vet Immunol Immunopathol, 2002 Mar. PMID 11943324
    5. CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Pan C, et al. Immunity, 1999 Oct. PMID 10549631

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD22 and CD72 contribute to the development of scleroderma in a murine model.
      Title: CD22 and CD72 contribute to the development of scleroderma in a murine model.
    2. Reverse Arthus reaction model in the skin was induced in mice lacking CD22 (CD22-/-), CD72 (CD72-/-), and both of them (CD22-/-/CD72-/-) by immune complex challenge. Results demonstrate that CD22 and CD72 expression contribute to the development of the reverse Arthus reaction model and CD22 and CD72 might be therapeutic targets for human IC-mediated diseases.
      Title: CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model.
    3. CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP.
      Title: CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.
    4. CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha.
      Title: CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα.
    5. CD5 and CD72 play a critical role in maintaining regulatory T and B cell homeostasis
      Title: Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis.
    6. These results strongly suggest that the Cd72(c) is a crucial modifier gene that regulates Fas(lpr)-induced autoimmune disease due to its reduced activity of B cell signal regulation.
      Title: Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease.
    7. Cd72 polymorphism affects susceptibility to lupus phenotypes.
      Title: A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus mice.
    8. CD72 is an inhibitory receptor on NK cells regulating cytokine production.
      Title: B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-gamma production but not cytotoxicity.
    9. CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance
      Title: Modulation of peripheral B cell tolerance by CD72 in a murine model.
    10. Strength of B-cell antigen receptor signals is strictly tuned by the interaction of CD100 with CD72; this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response.
      Title: Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B-cell differentiation antigen CD72
    Names
    lymphocyte antigen 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110320.2 → NP_001103790.1  B-cell differentiation antigen CD72 isoform 1

      See identical proteins and their annotated locations for NP_001103790.1

      Status: VALIDATED

      Source sequence(s)
      AL732506
      Consensus CDS
      CCDS51166.1
      UniProtKB/TrEMBL
      Q3UZ35, Q99L55
      Related
      ENSMUSP00000030179.5, ENSMUST00000030179.11
      Conserved Domains (2) summary
      smart00034
      Location:232 → 348
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl12013
      Location:137 → 209
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001110321.2 → NP_001103791.1  B-cell differentiation antigen CD72 isoform 3

      See identical proteins and their annotated locations for NP_001103791.1

      Status: VALIDATED

      Source sequence(s)
      AL732506
      Consensus CDS
      CCDS51165.1
      UniProtKB/TrEMBL
      Q3UNJ0, Q99L55
      Related
      ENSMUSP00000095709.4, ENSMUST00000098105.4
      Conserved Domains (2) summary
      smart00034
      Location:208 → 324
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl12013
      Location:113 → 185
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_001110322.2 → NP_001103792.1  B-cell differentiation antigen CD72 isoform 4

      See identical proteins and their annotated locations for NP_001103792.1

      Status: VALIDATED

      Source sequence(s)
      AL732506
      Consensus CDS
      CCDS51164.1
      UniProtKB/TrEMBL
      Q3UB58, Q99L55
      Related
      ENSMUSP00000095708.4, ENSMUST00000098104.10
      Conserved Domains (2) summary
      smart00034
      Location:178 → 287
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl12013
      Location:83 → 155
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. NM_001419973.1 → NP_001406902.1  B-cell differentiation antigen CD72 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL732506

    5. NM_001419974.1 → NP_001406903.1  B-cell differentiation antigen CD72 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL732506

    6. NM_001419975.1 → NP_001406904.1  B-cell differentiation antigen CD72 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL732506

    7. NM_001419976.1 → NP_001406905.1  B-cell differentiation antigen CD72 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL732506

    8. NM_001419977.1 → NP_001406906.1  B-cell differentiation antigen CD72 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL732506
      UniProtKB/TrEMBL
      A2AIN5
      Related
      ENSMUSP00000103558.2, ENSMUST00000107925.8

    9. NM_001419978.1 → NP_001406907.1  B-cell differentiation antigen CD72 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL732506

    10. NM_007654.3 → NP_031680.2  B-cell differentiation antigen CD72 isoform 2

      See identical proteins and their annotated locations for NP_031680.2

      Status: VALIDATED

      Source sequence(s)
      AL732506
      Consensus CDS
      CCDS38740.1
      UniProtKB/Swiss-Prot
      A2AIN6, P21855, Q64225
      UniProtKB/TrEMBL
      Q99L55
      Related
      ENSMUSP00000103559.2, ENSMUST00000107926.8
      Conserved Domains (2) summary
      smart00034
      Location:232 → 341
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl12013
      Location:137 → 209
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      43447724..43454708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537578.5 → XP_006537641.1  B-cell differentiation antigen CD72 isoform X3

      UniProtKB/TrEMBL
      Q99L55
      Conserved Domains (2) summary
      smart00034
      Location:240 → 356
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      COG1196
      Location:121 → 230
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006537582.3 → XP_006537645.1  B-cell differentiation antigen CD72 isoform X6

      See identical proteins and their annotated locations for XP_006537645.1

      Conserved Domains (2) summary
      smart00034
      Location:127 → 243
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      COG1196
      Location:28 → 117
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006537581.3 → XP_006537644.1  B-cell differentiation antigen CD72 isoform X6

      See identical proteins and their annotated locations for XP_006537644.1

      Conserved Domains (2) summary
      smart00034
      Location:127 → 243
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      COG1196
      Location:28 → 117
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21855.2 GenPept UniProtKB/Swiss-Prot:P21855

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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