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    CEP63 centrosomal protein 63 [ Homo sapiens (human) ]

    Gene ID: 80254, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CEP63provided by HGNC
    Official Full Name
    centrosomal protein 63provided by HGNC
    Primary source
    HGNC:HGNC:25815
    See related
    Ensembl:ENSG00000182923 MIM:614724; AllianceGenome:HGNC:25815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCKL6
    Summary
    This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 6.9), fat (RPKM 3.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q22.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (134485724..134782559)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (137230895..137527929)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134204566..134293855)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:134124670-134125376 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134126084-134126789 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:134145749-134146948 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:134181408-134182134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134183586-134184310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20562 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134205013-134205831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20563 Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene microRNA 4788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134245816-134246316 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene DPPA4 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 9743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134338253-134338753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134361872-134362713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134362971-134363635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134412480-134413158 Neighboring gene kyphoscoliosis peptidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20569 Neighboring gene Sharpr-MPRA regulatory region 6102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20571 Neighboring gene RNA, U6 small nuclear 1174, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134565355-134565854 Neighboring gene uncharacterized LOC105374121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20574 Neighboring gene EPH receptor B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1. Liu C, et al. Oncol Rep, 2021 Sep. PMID 34296302, Free PMC Article
    2. [Study on Cep63 expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1]. Liu CG, et al. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2021 Jan 7. PMID 33472304
    3. Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family. Einarsdottir E, et al. Hum Genet, 2015 Nov. PMID 26400686, Free PMC Article
    4. Computational investigation of pathogenic nsSNPs in CEP63 protein. Kumar A, et al. Gene, 2012 Jul 15. PMID 22555018
    5. Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma. Mahjabeen I, et al. Future Oncol, 2021 Sep. PMID 34156311

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1.
      Title: CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1.
    2. Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma.
      Title: Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma.
    3. Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC1.
      Title: Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1.
    4. CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression.
      Title: CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression.
    5. [Study on Cep63 expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1].
      Title: [Study on Cep63 expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1].
    6. Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication.
      Title: Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication.
    7. Study shows that Cep63 and Cep152 cooperatively generate a heterotetrameric alpha-helical bundle that functions in conjunction with its neighboring hydrophobic motifs to self-assemble into a higher-order cylindrical architecture capable of recruiting downstream components, including Plk4, a key regulator for centriole duplication. Mutations disrupting the self-assembly abrogate Plk4-mediated centriole duplication.
      Title: Molecular architecture of a cylindrical self-assembly at human centrosomes.
    8. CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated.
      Title: Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family.
    9. centrosomal Cdk1 signals were strongly diminished in cells treated with Cep63 siRNA when sc-54 was used for Cdk1 labeling
      Title: Cep63 recruits cdk1 to the centrosome-letter.
    10. both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation.
      Title: Cep63 and cep152 cooperate to ensure centriole duplication.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Seckel syndrome 6
    MedGen: C3553582 OMIM: 614728 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies 20 loci that influence adult height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13386, MGC78416

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction in response to DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 63 kDa
    Names
    centrosomal protein 63kDa
    centrosome protein CEP63

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032870.2 RefSeqGene

      Range
      5335..84309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042383.2 → NP_001035842.1  centrosomal protein of 63 kDa isoform c

      See identical proteins and their annotated locations for NP_001035842.1

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC109912, BC014050, BX499930, CX751767, N36992
      Consensus CDS
      CCDS43154.1
      UniProtKB/TrEMBL
      A0A804HKQ7
      Related
      ENSP00000328382.5, ENST00000332047.10
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:247 → 495
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001042384.2 → NP_001035843.1  centrosomal protein of 63 kDa isoform d

      See identical proteins and their annotated locations for NP_001035843.1

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC139764, AK023738, BG182631, BX499930, CX751767
      Consensus CDS
      CCDS43152.1
      UniProtKB/TrEMBL
      H0Y900
      Related
      ENSP00000346432.3, ENST00000354446.7
      Conserved Domains (2) summary
      COG1196
      Location:163 → 453
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa

    3. NM_001042400.3 → NP_001035859.1  centrosomal protein of 63 kDa isoform b

      See identical proteins and their annotated locations for NP_001035859.1

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS43153.1
      UniProtKB/TrEMBL
      A0A804HKH7
      Related
      ENSP00000372716.3, ENST00000383229.8
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:163 → 479
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001353108.3 → NP_001340037.1  centrosomal protein of 63 kDa isoform a

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS3086.1
      UniProtKB/Swiss-Prot
      D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0
      Related
      ENSP00000502085.1, ENST00000675561.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:163 → 528
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001353109.1 → NP_001340038.1  centrosomal protein of 63 kDa isoform e

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BC014050
      Consensus CDS
      CCDS93389.1
      UniProtKB/TrEMBL
      A0A804HIX3
      Related
      ENSP00000507263.1, ENST00000682458.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:136 → 463
      SMC_N; RecF/RecN/SMC N terminal domain

    6. NM_001353110.1 → NP_001340039.1  centrosomal protein of 63 kDa isoform b

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BC014050
      Consensus CDS
      CCDS43153.1
      UniProtKB/TrEMBL
      A0A804HKH7
      Related
      ENSP00000508291.1, ENST00000684217.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:163 → 479
      SMC_N; RecF/RecN/SMC N terminal domain

    7. NM_001353111.2 → NP_001340040.1  centrosomal protein of 63 kDa isoform b

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS43153.1
      UniProtKB/TrEMBL
      A0A804HKH7
      Related
      ENSP00000507217.1, ENST00000684677.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:163 → 479
      SMC_N; RecF/RecN/SMC N terminal domain

    8. NM_001353112.2 → NP_001340041.1  centrosomal protein of 63 kDa isoform b

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS43153.1
      UniProtKB/TrEMBL
      A0A804HKH7
      Related
      ENSP00000507704.1, ENST00000683608.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:163 → 479
      SMC_N; RecF/RecN/SMC N terminal domain

    9. NM_001353113.1 → NP_001340042.1  centrosomal protein of 63 kDa isoform f

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BG182631
      Consensus CDS
      CCDS93388.1
      UniProtKB/TrEMBL
      A0A804HKF0, H0YAL1
      Related
      ENSP00000507552.1, ENST00000683997.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:136 → 464
      SMC_N; RecF/RecN/SMC N terminal domain

    10. NM_001353117.2 → NP_001340046.1  centrosomal protein of 63 kDa isoform f

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BG182631
      Consensus CDS
      CCDS93388.1
      UniProtKB/TrEMBL
      A0A804HKF0, H0YAL1
      Related
      ENSP00000427526.2, ENST00000514678.2
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:136 → 464
      SMC_N; RecF/RecN/SMC N terminal domain

    11. NM_001353118.1 → NP_001340047.1  centrosomal protein of 63 kDa isoform g

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BC014050
      UniProtKB/TrEMBL
      A0A804HKQ7
      Conserved Domains (2) summary
      pfam17045
      Location:27 → 289
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:256 → 504
      SMC_N; RecF/RecN/SMC N terminal domain

    12. NM_001353119.2 → NP_001340048.1  centrosomal protein of 63 kDa isoform c

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS43154.1
      UniProtKB/TrEMBL
      A0A804HKQ7
      Related
      ENSP00000506728.1, ENST00000683861.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:247 → 495
      SMC_N; RecF/RecN/SMC N terminal domain

    13. NM_001353120.2 → NP_001340049.1  centrosomal protein of 63 kDa isoform c

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS43154.1
      UniProtKB/TrEMBL
      A0A804HKQ7
      Related
      ENSP00000507228.1, ENST00000682042.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:247 → 495
      SMC_N; RecF/RecN/SMC N terminal domain

    14. NM_001353121.2 → NP_001340050.1  centrosomal protein of 63 kDa isoform c

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS43154.1
      UniProtKB/TrEMBL
      A0A804HKQ7
      Related
      ENSP00000506828.1, ENST00000683177.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:247 → 495
      SMC_N; RecF/RecN/SMC N terminal domain

    15. NM_001353122.1 → NP_001340051.1  centrosomal protein of 63 kDa isoform c

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BC014050
      Consensus CDS
      CCDS43154.1
      UniProtKB/TrEMBL
      A0A804HKQ7
      Related
      ENSP00000507703.1, ENST00000682858.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:247 → 495
      SMC_N; RecF/RecN/SMC N terminal domain

    16. NM_001353123.2 → NP_001340052.1  centrosomal protein of 63 kDa isoform d

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BG182631
      Consensus CDS
      CCDS43152.1
      UniProtKB/TrEMBL
      H0Y900
      Related
      ENSP00000482219.1, ENST00000620544.5
      Conserved Domains (2) summary
      COG1196
      Location:163 → 453
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa

    17. NM_001353124.2 → NP_001340053.1  centrosomal protein of 63 kDa isoform d

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BG182631
      Consensus CDS
      CCDS43152.1
      UniProtKB/TrEMBL
      H0Y900
      Related
      ENSP00000423225.2, ENST00000512894.6
      Conserved Domains (2) summary
      COG1196
      Location:163 → 453
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa

    18. NM_001353125.2 → NP_001340054.1  centrosomal protein of 63 kDa isoform h

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS93392.1
      UniProtKB/TrEMBL
      A0A804HJ73, A0A804HKK0
      Related
      ENSP00000507256.1, ENST00000684492.1
      Conserved Domains (2) summary
      pfam17045
      Location:1 → 252
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:219 → 467
      SMC_N; RecF/RecN/SMC N terminal domain

    19. NM_001353126.2 → NP_001340055.1  centrosomal protein of 63 kDa isoform i

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      UniProtKB/TrEMBL
      A0A804HJP1
      Conserved Domains (2) summary
      pfam17045
      Location:6 → 159
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:42 → 320
      SMC_N; RecF/RecN/SMC N terminal domain

    20. NM_025180.5 → NP_079456.2  centrosomal protein of 63 kDa isoform a

      See identical proteins and their annotated locations for NP_079456.2

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Consensus CDS
      CCDS3086.1
      UniProtKB/Swiss-Prot
      D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0
      Related
      ENSP00000426129.1, ENST00000513612.7
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:163 → 528
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. NR_148352.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764

    2. NR_148353.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764

    3. NR_148354.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764
      Related
      ENST00000682013.1

    4. NR_148355.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010207, AC026117, AC109912, AC139764, BC014050
      Related
      ENST00000650279.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      134485724..134782559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453777.2 → XP_024309545.2  centrosomal protein of 63 kDa isoform X15

    2. XM_006713760.5 → XP_006713823.1  centrosomal protein of 63 kDa isoform X3

      See identical proteins and their annotated locations for XP_006713823.1

      UniProtKB/Swiss-Prot
      D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0
      Related
      ENSP00000506896.1, ENST00000683596.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:163 → 528
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_047449002.1 → XP_047304958.1  centrosomal protein of 63 kDa isoform X10

    4. XM_047449007.1 → XP_047304963.1  centrosomal protein of 63 kDa isoform X12

    5. XM_005247795.6 → XP_005247852.1  centrosomal protein of 63 kDa isoform X2

      Conserved Domains (2) summary
      pfam13094
      Location:253 → 376
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      pfam17045
      Location:27 → 289
      CEP63; Centrosomal protein of 63 kDa

    6. XM_047449010.1 → XP_047304966.1  centrosomal protein of 63 kDa isoform X13

    7. XM_047448999.1 → XP_047304955.1  centrosomal protein of 63 kDa isoform X6

    8. XM_047449015.1 → XP_047304971.1  centrosomal protein of 63 kDa isoform X18

      Related
      ENSP00000507472.1, ENST00000683940.1

    9. XM_047449005.1 → XP_047304961.1  centrosomal protein of 63 kDa isoform X10

    10. XM_017007249.2 → XP_016862738.1  centrosomal protein of 63 kDa isoform X7

      UniProtKB/TrEMBL
      A0A804HIX3
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:136 → 463
      SMC_N; RecF/RecN/SMC N terminal domain

    11. XM_005247797.4 → XP_005247854.1  centrosomal protein of 63 kDa isoform X3

      See identical proteins and their annotated locations for XP_005247854.1

      UniProtKB/Swiss-Prot
      D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0
      Related
      ENSP00000475903.1, ENST00000606977.5
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:163 → 528
      SMC_N; RecF/RecN/SMC N terminal domain

    12. XM_017007248.3 → XP_016862737.1  centrosomal protein of 63 kDa isoform X7

      UniProtKB/TrEMBL
      A0A804HIX3
      Related
      ENSP00000507548.1, ENST00000682402.1
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:136 → 463
      SMC_N; RecF/RecN/SMC N terminal domain

    13. XM_047449008.1 → XP_047304964.1  centrosomal protein of 63 kDa isoform X12

    14. XM_047449000.1 → XP_047304956.1  centrosomal protein of 63 kDa isoform X9

    15. XM_047449003.1 → XP_047304959.1  centrosomal protein of 63 kDa isoform X10

    16. XM_017007247.3 → XP_016862736.1  centrosomal protein of 63 kDa isoform X7

      UniProtKB/TrEMBL
      A0A804HIX3
      Conserved Domains (2) summary
      pfam17045
      Location:18 → 280
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:136 → 463
      SMC_N; RecF/RecN/SMC N terminal domain

    17. XM_047449009.1 → XP_047304965.1  centrosomal protein of 63 kDa isoform X12

    18. XM_024453769.2 → XP_024309537.1  centrosomal protein of 63 kDa isoform X4

      UniProtKB/TrEMBL
      A0A804HKR1
      Related
      ENSP00000508034.1, ENST00000683190.1
      Conserved Domains (2) summary
      pfam17045
      Location:1 → 252
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:135 → 500
      SMC_N; RecF/RecN/SMC N terminal domain

    19. XM_047449013.1 → XP_047304969.1  centrosomal protein of 63 kDa isoform X16

      UniProtKB/TrEMBL
      A0A804HL17
      Related
      ENSP00000508161.1, ENST00000684170.1

    20. XM_047449001.1 → XP_047304957.1  centrosomal protein of 63 kDa isoform X9

    21. XM_047449011.1 → XP_047304967.1  centrosomal protein of 63 kDa isoform X14

    22. XM_024453778.2 → XP_024309546.1  centrosomal protein of 63 kDa isoform X19

      UniProtKB/TrEMBL
      A0A804HJ73, A0A804HKK0
      Related
      ENSP00000507596.1, ENST00000682822.1
      Conserved Domains (2) summary
      pfam17045
      Location:1 → 252
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:219 → 467
      SMC_N; RecF/RecN/SMC N terminal domain

    23. XM_024453768.2 → XP_024309536.1  centrosomal protein of 63 kDa isoform X1

      Conserved Domains (2) summary
      pfam17045
      Location:29 → 291
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:174 → 539
      SMC_N; RecF/RecN/SMC N terminal domain

    24. XM_047448998.1 → XP_047304954.1  centrosomal protein of 63 kDa isoform X5

    25. XM_047449006.1 → XP_047304962.1  centrosomal protein of 63 kDa isoform X11

    26. XM_047448996.1 → XP_047304952.1  centrosomal protein of 63 kDa isoform X3

      UniProtKB/Swiss-Prot
      D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0

    27. XM_024453771.2 → XP_024309539.1  centrosomal protein of 63 kDa isoform X4

      UniProtKB/TrEMBL
      A0A804HKR1
      Conserved Domains (2) summary
      pfam17045
      Location:1 → 252
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:135 → 500
      SMC_N; RecF/RecN/SMC N terminal domain

    28. XM_024453772.2 → XP_024309540.1  centrosomal protein of 63 kDa isoform X8

      Conserved Domains (2) summary
      pfam17045
      Location:1 → 252
      CEP63; Centrosomal protein of 63 kDa
      cl25732
      Location:135 → 500
      SMC_N; RecF/RecN/SMC N terminal domain

    29. XM_047449014.1 → XP_047304970.1  centrosomal protein of 63 kDa isoform X17

    RNA

    1. XR_007095732.1 RNA Sequence

    2. XR_002959589.2 RNA Sequence

    3. XR_007095733.1 RNA Sequence

    4. XR_007095735.1 RNA Sequence

    5. XR_007095734.1 RNA Sequence

    6. XR_007095731.1 RNA Sequence

    7. XR_007095730.1 RNA Sequence

    8. XR_007095729.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      137230895..137527929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347996.1 → XP_054203971.1  centrosomal protein of 63 kDa isoform X15

    2. XM_054347974.1 → XP_054203949.1  centrosomal protein of 63 kDa isoform X3

    3. XM_054347987.1 → XP_054203962.1  centrosomal protein of 63 kDa isoform X10

    4. XM_054347991.1 → XP_054203966.1  centrosomal protein of 63 kDa isoform X12

    5. XM_054347973.1 → XP_054203948.1  centrosomal protein of 63 kDa isoform X2

    6. XM_054347994.1 → XP_054203969.1  centrosomal protein of 63 kDa isoform X13

    7. XM_054347980.1 → XP_054203955.1  centrosomal protein of 63 kDa isoform X6

    8. XM_054347999.1 → XP_054203974.1  centrosomal protein of 63 kDa isoform X18

    9. XM_054347989.1 → XP_054203964.1  centrosomal protein of 63 kDa isoform X10

    10. XM_054347983.1 → XP_054203958.1  centrosomal protein of 63 kDa isoform X7

    11. XM_054347975.1 → XP_054203950.1  centrosomal protein of 63 kDa isoform X3

    12. XM_054347982.1 → XP_054203957.1  centrosomal protein of 63 kDa isoform X7

    13. XM_054347992.1 → XP_054203967.1  centrosomal protein of 63 kDa isoform X12

    14. XM_054347985.1 → XP_054203960.1  centrosomal protein of 63 kDa isoform X9

    15. XM_054347988.1 → XP_054203963.1  centrosomal protein of 63 kDa isoform X10

    16. XM_054347981.1 → XP_054203956.1  centrosomal protein of 63 kDa isoform X7

    17. XM_054347993.1 → XP_054203968.1  centrosomal protein of 63 kDa isoform X12

    18. XM_054347977.1 → XP_054203952.1  centrosomal protein of 63 kDa isoform X4

    19. XM_054347997.1 → XP_054203972.1  centrosomal protein of 63 kDa isoform X16

      UniProtKB/TrEMBL
      A0A804HL17

    20. XM_054347986.1 → XP_054203961.1  centrosomal protein of 63 kDa isoform X9

    21. XM_054347995.1 → XP_054203970.1  centrosomal protein of 63 kDa isoform X14

    22. XM_054348000.1 → XP_054203975.1  centrosomal protein of 63 kDa isoform X19

      UniProtKB/TrEMBL
      A0A804HKK0

    23. XM_054347972.1 → XP_054203947.1  centrosomal protein of 63 kDa isoform X1

    24. XM_054347979.1 → XP_054203954.1  centrosomal protein of 63 kDa isoform X5

    25. XM_054347990.1 → XP_054203965.1  centrosomal protein of 63 kDa isoform X11

    26. XM_054347976.1 → XP_054203951.1  centrosomal protein of 63 kDa isoform X3

    27. XM_054347978.1 → XP_054203953.1  centrosomal protein of 63 kDa isoform X4

    28. XM_054347984.1 → XP_054203959.1  centrosomal protein of 63 kDa isoform X8

    29. XM_054347998.1 → XP_054203973.1  centrosomal protein of 63 kDa isoform X17

    RNA

    1. XR_008486804.1 RNA Sequence

    2. XR_008486807.1 RNA Sequence

    3. XR_008486805.1 RNA Sequence

    4. XR_008486808.1 RNA Sequence

    5. XR_008486806.1 RNA Sequence

    6. XR_008486803.1 RNA Sequence

    7. XR_008486802.1 RNA Sequence

    8. XR_008486801.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96MT8.1 GenPept UniProtKB/Swiss-Prot:Q96MT8

    Gene LinkOut

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