RHOBTB1 Rho related BTB domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RHOBTB1provided by HGNC
Official Full Name: Rho related BTB domain containing 1provided by HGNC
Primary source: HGNC:HGNC:18738
See related: Ensembl:ENSG00000072422 MIM:607351; AllianceGenome:HGNC:18738
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Expression: Broad expression in placenta (RPKM 10.3), kidney (RPKM 7.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q21.2

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (60860860..61001967, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (61726193..61858729, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (62629196..62761198, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination.
Title: Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination.
RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells.
Title: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells.
RhoBTB1 associates with ROCK1 and ROCK2 and its association with ROCK1 is via its Rho domain.
Title: RhoBTB1 interacts with ROCKs and inhibits invasion.
RhoBTB1 regulates the integrity of the Golgi complex through METTL7B. RhoBTB1 is required for expression of METTL7B and silencing of either protein leads to fragmentation of the Golgi. Loss of RhoBTB1 expression is linked to Golgi fragmentation in breast cancer cells. Restoration of normal RhoBTB1 expression rescues Golgi morphology and dramatically inhibits breast cancer cell invasion.
Title: The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B.
we found that miR-31 acts as an oncogene in colon cancer and identified RhoBTB1 as a new target of miR-31 further study demonstrated that miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1.
Title: The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma).
Title: Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BCD1607 (e-PCR)
- UniSTS:77896

STS-R82637 (e-PCR)
- UniSTS:7548

SHGC-58267 (e-PCR)
- UniSTS:54677

WI-11491 (e-PCR)
- UniSTS:60126

SHGC-148362 (e-PCR)
- UniSTS:176351

SHGC-36311 (e-PCR)
- UniSTS:30181

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242359.2 → NP_001229288.1 rho-related BTB domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_001229288.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same protein.

Source sequence(s)

AB018283, BC032848, BU624790, DA830304

Consensus CDS

CCDS7261.1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
NM_001350902.2 → NP_001337831.1 rho-related BTB domain-containing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AB018283, AK075129, BC041791, BQ574439

Consensus CDS

CCDS7261.1

UniProtKB/Swiss-Prot

O94844

Related

ENSP00000350595.4, ENST00000357917.4

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
NM_001350903.2 → NP_001337832.1 rho-related BTB domain-containing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AB018283, AC011197, BE046002, BQ574439, DA859805, DR004641

Consensus CDS

CCDS7261.1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
NM_001350904.2 → NP_001337833.1 rho-related BTB domain-containing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AB018283, BC032848, BU624790, BX389628, DA830304, DR002604

Consensus CDS

CCDS7261.1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
NM_001350905.2 → NP_001337834.1 rho-related BTB domain-containing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AB018283, BC032848, BU624790, DA793865, DA830304, DR002604

Consensus CDS

CCDS7261.1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
NM_001350906.2 → NP_001337835.1 rho-related BTB domain-containing protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AB018283, AC011197, AC027678, BE046002, BQ574439, DA859805, DR004641

Conserved Domains (3) summary

smart00225
Location:276 → 335

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:356 → 461

BTB; BTB/POZ domain

cl21455
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001350907.2 → NP_001337836.1 rho-related BTB domain-containing protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AB018283, AC027678, BQ574439, DA781491, DR004641

Conserved Domains (3) summary

smart00225
Location:276 → 335

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:356 → 461

BTB; BTB/POZ domain

cl21455
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001350908.2 → NP_001337837.1 rho-related BTB domain-containing protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AB018283, AC011197, AC027678, BE046002, BQ574439, DA859805, DR004641

Conserved Domains (3) summary

smart00225
Location:276 → 335

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:356 → 461

BTB; BTB/POZ domain

cl21455
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001350909.2 → NP_001337838.1 rho-related BTB domain-containing protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AB018283, AC027678, AI935070, BC032848, BQ574439, DA930841, DR004641

Conserved Domains (3) summary

smart00225
Location:276 → 335

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:356 → 461

BTB; BTB/POZ domain

cl21455
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001350910.2 → NP_001337839.1 rho-related BTB domain-containing protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AB018283, BC032848, BQ574439, DA930841, DR002604, DR004641

Conserved Domains (3) summary

smart00225
Location:276 → 335

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:356 → 461

BTB; BTB/POZ domain

cl21455
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001350911.2 → NP_001337840.1 rho-related BTB domain-containing protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AB018283, AC027678, BQ574439, DA793865, DA930841, DR004641

Conserved Domains (3) summary

smart00225
Location:276 → 335

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:356 → 461

BTB; BTB/POZ domain

cl21455
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_014836.5 → NP_055651.1 rho-related BTB domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_055651.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform. Variants 1-6 encode the same protein (isoform 1).

Source sequence(s)

AB018283, BC041791, BQ574439, DB453441

Consensus CDS

CCDS7261.1

UniProtKB/Swiss-Prot

O94844

Related

ENSP00000338671.5, ENST00000337910.10

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

60860860..61001967 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426080.1 → XP_047282036.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426086.1 → XP_047282042.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426099.1 → XP_047282055.1 rho-related BTB domain-containing protein 1 isoform X2
XM_047426092.1 → XP_047282048.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_024448271.2 → XP_024304039.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
XM_011540425.2 → XP_011538727.1 rho-related BTB domain-containing protein 1 isoform X2

Conserved Domains (5) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

smart00174
Location:17 → 208

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

smart00225
Location:486 → 583

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:476 → 578

BTB; BTB/POZ domain

cl02518
Location:406 → 453

BTB; BTB/POZ domain
XM_011540424.2 → XP_011538726.1 rho-related BTB domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_011538726.1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
XM_024448270.2 → XP_024304038.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
XM_047426083.1 → XP_047282039.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_006718085.2 → XP_006718148.1 rho-related BTB domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006718148.1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
XM_047426088.1 → XP_047282044.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426082.1 → XP_047282038.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426077.1 → XP_047282033.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426078.1 → XP_047282034.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426098.1 → XP_047282054.1 rho-related BTB domain-containing protein 1 isoform X2
XM_047426095.1 → XP_047282051.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426087.1 → XP_047282043.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426091.1 → XP_047282047.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_024448272.2 → XP_024304040.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
XM_047426097.1 → XP_047282053.1 rho-related BTB domain-containing protein 1 isoform X2
XM_047426094.1 → XP_047282050.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426074.1 → XP_047282030.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_017017002.3 → XP_016872491.1 rho-related BTB domain-containing protein 1 isoform X2

Conserved Domains (5) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

smart00174
Location:17 → 208

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

smart00225
Location:486 → 583

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:476 → 578

BTB; BTB/POZ domain

cl02518
Location:406 → 453

BTB; BTB/POZ domain
XM_047426081.1 → XP_047282037.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426096.1 → XP_047282052.1 rho-related BTB domain-containing protein 1 isoform X2
XM_047426089.1 → XP_047282045.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426090.1 → XP_047282046.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426084.1 → XP_047282040.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426075.1 → XP_047282031.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426076.1 → XP_047282032.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_047426093.1 → XP_047282049.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_017017000.3 → XP_016872489.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
XM_047426079.1 → XP_047282035.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_024448273.2 → XP_024304041.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

cd18355
Location:248 → 460

BTB1_POZ_RHOBTB1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18358
Location:465 → 590

BTB2_POZ_RHOBTB1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)

cd18530
Location:593 → 692

BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
XM_047426100.1 → XP_047282056.1 rho-related BTB domain-containing protein 1 isoform X3
XM_011540428.2 → XP_011538730.1 rho-related BTB domain-containing protein 1 isoform X4

Conserved Domains (4) summary

cd01873
Location:13 → 207

RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases

smart00174
Location:17 → 208

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

smart00225
Location:396 → 455

BTB; Broad-Complex, Tramtrack and Bric a brac

cl02518
Location:406 → 453

BTB; BTB/POZ domain
XM_047426103.1 → XP_047282059.1 rho-related BTB domain-containing protein 1 isoform X4
XM_047426104.1 → XP_047282060.1 rho-related BTB domain-containing protein 1 isoform X4
XM_047426105.1 → XP_047282061.1 rho-related BTB domain-containing protein 1 isoform X4
XM_047426102.1 → XP_047282058.1 rho-related BTB domain-containing protein 1 isoform X4

RNA

XR_007062022.1 RNA Sequence
XR_007062020.1 RNA Sequence
XR_007062021.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

61726193..61858729 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367310.1 → XP_054223285.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367326.1 → XP_054223301.1 rho-related BTB domain-containing protein 1 isoform X2
XM_054367316.1 → XP_054223291.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367303.1 → XP_054223278.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367323.1 → XP_054223298.1 rho-related BTB domain-containing protein 1 isoform X2
XM_054367307.1 → XP_054223282.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367312.1 → XP_054223287.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367324.1 → XP_054223299.1 rho-related BTB domain-containing protein 1 isoform X2
XM_054367296.1 → XP_054223271.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367300.1 → XP_054223275.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367301.1 → XP_054223276.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367302.1 → XP_054223277.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367299.1 → XP_054223274.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367314.1 → XP_054223289.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367308.1 → XP_054223283.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367329.1 → XP_054223304.1 rho-related BTB domain-containing protein 1 isoform X2
XM_054367322.1 → XP_054223297.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367313.1 → XP_054223288.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367318.1 → XP_054223293.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367297.1 → XP_054223272.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367328.1 → XP_054223303.1 rho-related BTB domain-containing protein 1 isoform X2
XM_054367319.1 → XP_054223294.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367295.1 → XP_054223270.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367311.1 → XP_054223286.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367320.1 → XP_054223295.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367306.1 → XP_054223281.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367325.1 → XP_054223300.1 rho-related BTB domain-containing protein 1 isoform X2
XM_054367321.1 → XP_054223296.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367327.1 → XP_054223302.1 rho-related BTB domain-containing protein 1 isoform X2
XM_054367315.1 → XP_054223290.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367317.1 → XP_054223292.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367309.1 → XP_054223284.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367298.1 → XP_054223273.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367304.1 → XP_054223279.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367305.1 → XP_054223280.1 rho-related BTB domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

O94844
XM_054367330.1 → XP_054223305.1 rho-related BTB domain-containing protein 1 isoform X3
XM_054367331.1 → XP_054223306.1 rho-related BTB domain-containing protein 1 isoform X4
XM_054367332.1 → XP_054223307.1 rho-related BTB domain-containing protein 1 isoform X4
XM_054367334.1 → XP_054223309.1 rho-related BTB domain-containing protein 1 isoform X4
XM_054367335.1 → XP_054223310.1 rho-related BTB domain-containing protein 1 isoform X4
XM_054367333.1 → XP_054223308.1 rho-related BTB domain-containing protein 1 isoform X4