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    Naga N-acetyl galactosaminidase, alpha [ Mus musculus (house mouse) ]

    Gene ID: 17939, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Nagaprovided by MGI
    Official Full Name
    N-acetyl galactosaminidase, alphaprovided by MGI
    Primary source
    MGI:MGI:1261422
    See related
    Ensembl:ENSMUSG00000022453 AllianceGenome:MGI:1261422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including glycoside catabolic process; glycosylceramide catabolic process; and oligosaccharide metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Is expressed in nervous system and skeleton. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 76.1), kidney adult (RPKM 46.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Naga in Genome Data Viewer
    Location:
    15 E1; 15 38.56 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82213746..82222983, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82329532..82338884, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52180 Neighboring gene septin 3 Neighboring gene STARR-seq mESC enhancer starr_39292 Neighboring gene WBP2 N-terminal like Neighboring gene STARR-seq mESC enhancer starr_39293 Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene nuclear encoded rRNA 5S 41 Neighboring gene single-pass membrane protein with aspartate rich tail 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine alpha-N-acetylgalactosaminidase: isolation and expression of a full-length cDNA and genomic organization: further evidence of an alpha-galactosidase gene family. Wang AM, et al. Mol Genet Metab, 1998 Oct. PMID 9787108
    2. Molecular cloning, structural organization, sequence, chromosomal assignment, and expression of the mouse alpha-N-acetylgalactosaminidase gene. Herrmann T, et al. Gene, 1998 May 12. PMID 9602128
    3. Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease. Tajima Y, et al. Am J Hum Genet, 2009 Nov. PMID 19853240, Free PMC Article
    4. Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Hentges KE, et al. Genomics, 2002 Aug. PMID 12160734
    5. The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes. Harper J, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670299, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Use of a modified Naga in the development of enzyme replacement therapy for Fabry disease is reported.
      Title: Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminidase
    Names
    alpha-galactosidase B
    NP_001398349.1
    NP_032695.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411420.1 → NP_001398349.1  alpha-N-acetylgalactosaminidase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104325

    2. NM_008669.5 → NP_032695.3  alpha-N-acetylgalactosaminidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_032695.3

      Status: VALIDATED

      Source sequence(s)
      AC104325
      Consensus CDS
      CCDS27686.1
      UniProtKB/Swiss-Prot
      O88620, Q8R437, Q8VDK2, Q9QWR8
      UniProtKB/TrEMBL
      Q3U6T2
      Related
      ENSMUSP00000023088.8, ENSMUST00000023088.8
      Conserved Domains (1) summary
      cl07893
      Location:25 → 394
      AmyAc_family; Alpha amylase catalytic domain family

    RNA

    1. NR_177249.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104325

    2. NR_177250.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104325

    3. NR_177251.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104325

    4. NR_177252.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104325

    5. NR_177253.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104325

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82213746..82222983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001355546.1: Suppressed sequence

      Description
      NM_001355546.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWR8.2 GenPept UniProtKB/Swiss-Prot:Q9QWR8

    Gene LinkOut

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