Grm8 glutamate receptor, metabotropic 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grm8provided by MGI
Official Full Name: glutamate receptor, metabotropic 8provided by MGI
Primary source: MGI:MGI:1351345
See related: Ensembl:ENSMUSG00000024211 AllianceGenome:MGI:1351345
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GluR8; Gprc1h; mGluR8; A230002O04
Summary: Enables group III metabotropic glutamate receptor activity. Predicted to be involved in several processes, including adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Predicted to act upstream of or within signal transduction. Predicted to be located in neuron projection; neuronal cell body; and presynaptic membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including eye; gonad; ileum; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 2.3), CNS E18 (RPKM 1.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1- A3.2; 6 11.97 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (27275120..28135094, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (27275121..28135146, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation.
Title: Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation.
Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum.
Title: Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum.
the data of this study revealed very different roles for mGlu8 in amygdala synaptic transmission, fear learning and its expression
Title: Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.
In the dentate gyrus of mGluR8 receptor-deficient mice, effects from selective agonists are linked to the lateral and medial perforant pathway.
Title: Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.
mGluR8 is an important regulator of excitatory transmission in the bed nucleus of the stria terminalis, and is selectively disrupted by both acute and chronic stress.
Title: mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.
mGluR8 deficiency decreased measures of anxiety in the elevated plus maze and the acoustic startle response in female mice.
Title: Sex-dependent cognitive phenotype of mice lacking mGluR8.
Might be potential target for disorders with pathophysiological changes in brain areas where mGlu8 modulates glutamate and GABA transmission, especially in anxiety disorders involving exaggerated contextual fear.
Title: The effect of mGlu8 deficiency in animal models of psychiatric diseases.
mGluR8 was localized in two broad bands, one each in the OFF and ON layers of the IPL; mGluR8 immunoreactivity was evident in the OFF plexus of cholinergic amacrine cell processes
Title: Distribution of group-III metabotropic glutamate receptors in the retina.
Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8.
Title: Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8.
Naive mGlu8 receptor-deficient mice show increased anxiety-related behavior in the elevated plus maze in low illumination conditions (red light) compared to wild-type mice.
Title: Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

25.MMHAP9FRA10.seq (e-PCR)
- UniSTS:123707

REN110736 (e-PCR)
- UniSTS:435532

d4mit9 (e-PCR)
- UniSTS:121933

33.MMHAP68FRC12.seq (e-PCR)
- UniSTS:124047

Gprc1h (e-PCR), detects polymorphism
- UniSTS:143265

D6Mit89 (e-PCR), detects polymorphism
- UniSTS:130990

REN114198 (e-PCR)
- UniSTS:438993

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables group III metabotropic glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables group III metabotropic glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables group III metabotropic glutamate receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metabotropic glutamate receptor 8

Names: G protein coupled receptor, family C, group 1, member H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311072.2 → NP_001298001.1 metabotropic glutamate receptor 8 isoform 2 precursor

See identical proteins and their annotated locations for NP_001298001.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is of the same size as isoform 1, but contains a distinct C-terminus. Variants 2, 5, 6, and 7 all encode the same isoform (2).

Source sequence(s)

AC035247, AC067970, AC068066, AC074223, AC079957, AC121497

Consensus CDS

CCDS80495.1

UniProtKB/Swiss-Prot

P47743, Q6B964

UniProtKB/TrEMBL

B7ZMR4

Conserved Domains (3) summary

cd15454
Location:582 → 892

7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06376
Location:40 → 504

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:512 → 562

NCD3G; Nine Cysteines Domain of family 3 GPCR
NM_001361125.2 → NP_001348054.1 metabotropic glutamate receptor 8 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC035247, AC067970, AC068066, AC074223, AC079957, AC121497

Consensus CDS

CCDS39443.1

UniProtKB/TrEMBL

Q05BD6

Conserved Domains (3) summary

cd15454
Location:582 → 892

7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:512 → 562

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:40 → 504

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
NM_001409900.1 → NP_001396829.1 metabotropic glutamate receptor 8 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC035247, AC067970, AC068066, AC074223, AC079957, AC121497

UniProtKB/TrEMBL

Q05BD6

Related

ENSMUSP00000110979.3, ENSMUST00000115324.9
NM_001409901.1 → NP_001396830.1 metabotropic glutamate receptor 8 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC035247, AC067970, AC068066, AC074223, AC079957, AC121497

UniProtKB/Swiss-Prot

P47743, Q6B964

UniProtKB/TrEMBL

B7ZMR4

Related

ENSMUSP00000087998.4, ENSMUST00000090512.10
NM_001409903.1 → NP_001396832.1 metabotropic glutamate receptor 8 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC035247, AC067970, AC068066, AC074223, AC079957, AC121497

UniProtKB/Swiss-Prot

P47743, Q6B964

UniProtKB/TrEMBL

B7ZMR4
NM_001409904.1 → NP_001396833.1 metabotropic glutamate receptor 8 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC035247, AC067970, AC068066, AC074223, AC079957, AC121497

UniProtKB/Swiss-Prot

P47743, Q6B964

UniProtKB/TrEMBL

B7ZMR4
NM_001409905.1 → NP_001396834.1 metabotropic glutamate receptor 8 isoform 3

Status: VALIDATED

Source sequence(s)

AC035247, AC068066, AC074223, AC121497
NM_001409906.1 → NP_001396835.1 metabotropic glutamate receptor 8 isoform 4

Status: VALIDATED

Source sequence(s)

AC035247, AC068066, AC074223, AC121497
NM_001409907.1 → NP_001396836.1 metabotropic glutamate receptor 8 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC035247, AC067970, AC079957, AC121497
NM_001409908.1 → NP_001396837.1 metabotropic glutamate receptor 8 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC035247, AC067970, AC079957, AC121497
NM_001409909.1 → NP_001396838.1 metabotropic glutamate receptor 8 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC035247, AC067970, AC079957, AC121497
NM_001409910.1 → NP_001396839.1 metabotropic glutamate receptor 8 isoform 6

Status: VALIDATED

Source sequence(s)

AC035247, AC121497
NM_001409911.1 → NP_001396840.1 metabotropic glutamate receptor 8 isoform 7

Status: VALIDATED

Source sequence(s)

AC035247, AC115890, AC121497
NM_001409912.1 → NP_001396841.1 metabotropic glutamate receptor 8 isoform 8

Status: VALIDATED

Source sequence(s)

AC035247, AC068066, AC074223, AC115890, AC121497
NM_001409913.1 → NP_001396842.1 metabotropic glutamate receptor 8 isoform 9

Status: VALIDATED

Source sequence(s)

AC035247, AC121497
NM_008174.4 → NP_032200.2 metabotropic glutamate receptor 8 isoform 1 precursor

See identical proteins and their annotated locations for NP_032200.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AC035247, AC067970, AC068066, AC074223, AC079957, AC121497

Consensus CDS

CCDS39443.1

UniProtKB/TrEMBL

Q05BD6

Related

ENSMUSP00000110978.2, ENSMUST00000115323.8

Conserved Domains (3) summary

cd15454
Location:582 → 892

7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:512 → 562

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:40 → 504

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

27275120..28135094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504991.4 → XP_006505054.1 metabotropic glutamate receptor 8 isoform X2

See identical proteins and their annotated locations for XP_006505054.1

UniProtKB/TrEMBL

Q05BD6

Conserved Domains (3) summary

cd15454
Location:582 → 892

7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:512 → 562

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:40 → 504

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
XM_006504990.5 → XP_006505053.1 metabotropic glutamate receptor 8 isoform X2

See identical proteins and their annotated locations for XP_006505053.1

UniProtKB/TrEMBL

Q05BD6

Conserved Domains (3) summary

cd15454
Location:582 → 892

7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:512 → 562

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:40 → 504

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
XM_030255175.2 → XP_030111035.1 metabotropic glutamate receptor 8 isoform X3

Conserved Domains (1) summary

cl10011
Location:40 → 385

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily