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    Stimate STIM activating enhancer [ Mus musculus (house mouse) ]

    Gene ID: 69179, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Stimateprovided by MGI
    Official Full Name
    STIM activating enhancerprovided by MGI
    Primary source
    MGI:MGI:1921500
    See related
    Ensembl:ENSMUSG00000006526 AllianceGenome:MGI:1921500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem110; 1810038N08Rik; 2310014H19Rik
    Summary
    Predicted to enable calcium channel regulator activity. Predicted to be involved in activation of store-operated calcium channel activity and calcium-mediated signaling using intracellular calcium source. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cortical endoplasmic reticulum and membrane. Is expressed in lung; spleen; stomach; and testis. Orthologous to several human genes including STIMATE (STIM activating enhancer). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 15.9), ovary adult (RPKM 12.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 B; 14 19.09 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30547533..30599167)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30825575..30877210)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Scm-like with four mbt domains 1 Neighboring gene RIKEN cDNA 1700087M22 gene Neighboring gene transformer 2 beta homolog pseudogene Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter alpha-trypsin inhibitor, heavy chain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility. Tremblay MG, et al. Cell Cycle, 2016 Sep. PMID 27399837, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cortical endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    store-operated calcium entry regulator STIMATE
    Names
    STIM-activating enhancer encoded by TMEM110
    transmembrane protein 110

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028839.4 → NP_083115.3  store-operated calcium entry regulator STIMATE

      See identical proteins and their annotated locations for NP_083115.3

      Status: VALIDATED

      Source sequence(s)
      AK009341, BE944885, CJ180452, CT025528
      Consensus CDS
      CCDS26899.1
      UniProtKB/Swiss-Prot
      Q3U2J0, Q3UF25, Q8C691, Q8R3U0, Q9D7D4, Q9D8S1
      Related
      ENSMUSP00000006701.6, ENSMUST00000006701.8
      Conserved Domains (1) summary
      pfam12400
      Location:100 → 219
      STIMATE; STIMATE family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30547533..30599167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247992.2 → XP_030103852.1  store-operated calcium entry regulator STIMATE isoform X1

      Conserved Domains (1) summary
      pfam12400
      Location:58 → 177
      STIMATE; STIMATE family

    2. XM_036158839.1 → XP_036014732.1  store-operated calcium entry regulator STIMATE isoform X2

      Conserved Domains (1) summary
      pfam12400
      Location:6 → 85
      STIMATE; STIMATE family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UF25.1 GenPept UniProtKB/Swiss-Prot:Q3UF25

    Gene LinkOut

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