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    Gon7 GON7 subunit of KEOPS complex [ Mus musculus (house mouse) ]

    Gene ID: 100233175, updated on 8-Feb-2024

    Summary

    Official Symbol
    Gon7provided by MGI
    Official Full Name
    GON7 subunit of KEOPS complexprovided by MGI
    Primary source
    MGI:MGI:4845848
    See related
    Ensembl:ENSMUSG00000091931 AllianceGenome:MGI:4845848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of EKC/KEOPS complex. Orthologous to human GON7 (GON7 subunit of KEOPS complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.8), CNS E14 (RPKM 10.5) and 28 other tissues See more
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    Genomic context

    See Gon7 in Genome Data Viewer
    Location:
    12 E; 12 52.14 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102719534..102724069, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102753275..102757810, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9862 Neighboring gene STARR-positive B cell enhancer ABC_E9390 Neighboring gene predicted gene 20604 Neighboring gene modulator of apoptosis 1 Neighboring gene lysosomal enzyme trafficking factor Neighboring gene STARR-seq mESC enhancer starr_33118 Neighboring gene STARR-seq mESC enhancer starr_33119 Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 (putative) Neighboring gene BTB domain containing 7 Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough Gm20604

    Readthrough gene: Gm20604, Included gene: Moap1

    Potential readthrough

    Included gene: Itpk1

    Clone Names

    • MGC25937, MGC60472

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in tRNA threonylcarbamoyladenosine modification ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of EKC/KEOPS complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    EKC/KEOPS complex subunit GON7
    Names
    GON7, KEOPS complex subunit homolog
    uncharacterized protein C14orf142 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142938.1NP_001136410.1  EKC/KEOPS complex subunit GON7

      See identical proteins and their annotated locations for NP_001136410.1

      Status: VALIDATED

      Source sequence(s)
      AC132315, AK010878
      Consensus CDS
      CCDS49148.1
      UniProtKB/Swiss-Prot
      P0C8B4
      Related
      ENSMUSP00000136425.2, ENSMUST00000173969.2
      Conserved Domains (1) summary
      pfam15387
      Location:396
      DUF4611; Domain of unknown function (DUF4611)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102719534..102724069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)