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    Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24795, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Serpina3nprovided by RGD
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3Nprovided by RGD
    Primary source
    RGD:3747
    See related
    Ensembl:ENSRNOG00000029949 AllianceGenome:RGD:3747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SPI3; Spin3; CPi-26; Spin2c; Spi-2.2
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to organic cyclic compound; and response to vitamin B6. Located in extracellular space. Used to study adult respiratory distress syndrome. Biomarker of uveitis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 4717.5) See more
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    Genomic context

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    Location:
    6q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (129088392..129095950)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (123323623..123331181)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (128073344..128080878)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) proteinase inhibitor, clade A, member 3C Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3L Neighboring gene small nucleolar RNA SNORA17 Neighboring gene goosecoid homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and prokaryotic expression of rat homolog of Serpina3n and its expression change during liver regeneration. Wang GP, et al. Genet Mol Res, 2012 Sep 3. PMID 23007996
    2. Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-α-stimulated HT-29 cells. Yanaka N, et al. Mol Nutr Food Res, 2011 Apr. PMID 21462331
    3. Peripheral nerve injury induced expression of mRNA for serine protease inhibitor 3 in the rat facial and hypoglossal nuclei but not in the spinal cord. Gesase AP, et al. Ital J Anat Embryol, 2007 Jul-Sep. PMID 18078237
    4. Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe alpha1-antitrypsin deficiency. Hollander C, et al. BMC Pulm Med, 2007 Jan 29. PMID 17261175, Free PMC Article
    5. Inflammation inhibitors were remarkably up-regulated in plasma of severe acute respiratory syndrome patients at progressive phase. Wan J, et al. Proteomics, 2006 May. PMID 16649161, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
      Title: The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
    2. The sequence of HM448398 was highly homologous to that of rat Serpina3n, suggesting that it may be a homolog of Serpina3n.
      Title: Cloning and prokaryotic expression of rat homolog of Serpina3n and its expression change during liver regeneration.
    3. SPI-3 may be involved during early events of modulating the activities of serine proteases following nerve injury.
      Title: Peripheral nerve injury induced expression of mRNA for serine protease inhibitor 3 in the rat facial and hypoglossal nuclei but not in the spinal cord.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93363

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to glucocorticoid stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to cytokine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to vitamin B6 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor A3N
    Names
    SPI-3
    contrapsin-like protease inhibitor 6
    serine protease inhibitor 2c
    serine protease inhibitor 3
    serpin A3N
    serpina3n-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031531.3 → NP_113719.3  serine protease inhibitor A3N precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P09006, Q03312
      UniProtKB/TrEMBL
      A0A0H2UHI5, A6JEQ8
      Related
      ENSRNOP00000014073.4, ENSRNOT00000014073.6
      Conserved Domains (1) summary
      cd19551
      Location:37 → 418
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      129088392..129095950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09006.3 GenPept UniProtKB/Swiss-Prot:P09006

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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