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    atg-3 Ubiquitin-like-conjugating enzyme ATG3 [ Caenorhabditis elegans ]

    Gene ID: 176921, updated on 23-May-2024

    Summary

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    Gene symbol
    atg-3
    Gene description
    Ubiquitin-like-conjugating enzyme ATG3
    Primary source
    WormBase:WBGene00021922
    Locus tag
    CELE_Y55F3AM.4
    See related
    AllianceGenome:WB:WBGene00021922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Atg8 ligase activity. Involved in macroautophagy. Predicted to be part of cytoplasmic ubiquitin ligase complex. Predicted to be active in cytosol. Is expressed in body wall musculature; pharynx; reproductive system; and seam cell. Orthologous to human ATG3 (autophagy related 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See atg-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (1010512..1012502)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SPIN90/Ldb17 leucine-rich domain-containing protein Neighboring gene Mitochondrial inner membrane protease subunit 2;Peptidase S26 domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene RRM domain-containing protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small differences make a big impact: Structural insights into the differential function of the 2 Atg8 homologs in C. elegans. Wu F, et al. Autophagy, 2016. PMID 27046254, Free PMC Article
    2. Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development. Huang S, et al. Autophagy, 2013 Feb 1. PMID 23108454, Free PMC Article
    3. C. elegans screen identifies autophagy genes specific to multicellular organisms. Tian Y, et al. Cell, 2010 Jun 11. PMID 20550938
    4. The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery. Lin L, et al. J Cell Biol, 2013 Apr 1. PMID 23530068, Free PMC Article
    5. Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Wu F, et al. Mol Cell, 2015 Dec 17. PMID 26687600

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Atg8-family ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Atg8-family ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like-conjugating enzyme ATG3
    NP_001368247.1
    • Confirmed by transcript evidence
    NP_500024.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1010512..1012502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067623.7 → NP_500024.1  Ubiquitin-like-conjugating enzyme ATG3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N369
      Conserved Domains (3) summary
      pfam03986
      Location:8 → 120
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:196 → 256
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
      pfam10381
      Location:277 → 300
      Autophagy_C; Autophagocytosis associated protein C-terminal

    2. NM_001380030.1 → NP_001368247.1  Ubiquitin-like-conjugating enzyme ATG3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRD2
      Conserved Domains (1) summary
      pfam03987
      Location:2 → 90
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    Nucleotide Protein
    Heading Accession and Version

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