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    Chn2 chimerin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84031, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Chn2provided by RGD
    Official Full Name
    chimerin 2provided by RGD
    Primary source
    RGD:620140
    See related
    Ensembl:ENSRNOG00000009411 AllianceGenome:RGD:620140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTPase activator activity. Involved in acrosome assembly. Predicted to be located in synapse. Orthologous to human CHN2 (chimerin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 337.8), Testes (RPKM 218.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84478989..84738068)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83148616..83407711)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84423708..84452989)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene carboxypeptidase, vitellogenic-like Neighboring gene uncharacterized LOC120102282 Neighboring gene uncharacterized LOC102553678 Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 1 Neighboring gene proline rich 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis. Leung T, et al. J Biol Chem, 1993 Feb 25. PMID 8440677
    2. Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain. Leung T, et al. J Biol Chem, 1994 Apr 29. PMID 8175705
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phorbol ester receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-chimaerin
    Names
    beta-chimerin
    chimerin (chimaerin) 2
    rho GTPase-activating protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032084.2 → NP_114473.2  beta-chimaerin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5Y7G2, A0A8I6A2H3, A6K0U4
      Related
      ENSRNOP00000077359.1, ENSRNOT00000097615.1
      Conserved Domains (3) summary
      cd10352
      Location:52 → 138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:275 → 468
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:210 → 270
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      84478989..84738068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108464.2 → XP_038964392.1  beta-chimaerin isoform X1

      UniProtKB/Swiss-Prot
      Q03070
      Conserved Domains (2) summary
      cd04372
      Location:129 → 322
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:64 → 124
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    2. XM_063286763.1 → XP_063142833.1  beta-chimaerin isoform X1

    3. XM_039108465.2 → XP_038964393.1  beta-chimaerin isoform X2

      UniProtKB/Swiss-Prot
      Q03070
      UniProtKB/TrEMBL
      A6K0U6, G3V773
      Conserved Domains (2) summary
      cd04372
      Location:102 → 295
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:37 → 97
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    4. XM_039108467.2 → XP_038964395.1  beta-chimaerin isoform X3

      UniProtKB/Swiss-Prot
      Q03070
      UniProtKB/TrEMBL
      A0A8I5ZYQ0
      Conserved Domains (2) summary
      cd04372
      Location:84 → 277
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:19 → 79
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    5. XM_039108466.2 → XP_038964394.1  beta-chimaerin isoform X2

      UniProtKB/Swiss-Prot
      Q03070
      UniProtKB/TrEMBL
      A6K0U6, G3V773
      Related
      ENSRNOP00000012655.3
      Conserved Domains (2) summary
      cd04372
      Location:102 → 295
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:37 → 97
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    6. XM_063286764.1 → XP_063142834.1  beta-chimaerin isoform X2

      UniProtKB/TrEMBL
      A6K0U6, G3V773
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03070.1 GenPept UniProtKB/Swiss-Prot:Q03070

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