Tesk1 testis associated actin remodelling kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tesk1provided by RGD
Official Full Name: testis associated actin remodelling kinase 1provided by RGD
Primary source: RGD:62059
See related: Ensembl:ENSRNOG00000053729 AllianceGenome:RGD:62059
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein C-terminus binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of protein phosphorylation; positive regulation of stress fiber assembly; and spermatogenesis. Located in perinuclear region of cytoplasm. Colocalizes with cytoplasmic vesicle. Orthologous to human TESK1 (testis associated actin remodelling kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 161.5), Muscle (RPKM 63.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62487763..62493492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (57691922..57697698)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (58937615..58943358)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-fat diet-induced vagal afferent dysfunction via upregulation of 2-pore domain potassium TRESK channel.
Title: High-fat diet-induced vagal afferent dysfunction via upregulation of 2-pore domain potassium TRESK channel.
TESK1 plays important roles in promyelinating Schwann cells, potentially through subcellular localization change and participation in integrin-mediated actin reorganization.
Title: Spatiotemporal expression of testicular protein kinase 1 after rat sciatic nerve injury.
By selectively modulating the downstream effects of Spry2, Tesk1 may thus serve as a molecular determinant of the signaling outcome.
Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140696 (e-PCR)
- UniSTS:222763

RH134422 (e-PCR)
- UniSTS:217702

RH141088 (e-PCR)
- UniSTS:223086

TESK1-1 (e-PCR)
- UniSTS:513744

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of vesicle localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of vesicle localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dual specificity testis-specific protein kinase 1

Names: testicular protein kinase 1; testis specific protein kinase 1; testis-specific kinase 1

NP_113766.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031578.2 → NP_113766.1 dual specificity testis-specific protein kinase 1

See identical proteins and their annotated locations for NP_113766.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63572

UniProtKB/TrEMBL

A6IJ14

Related

ENSRNOP00000071965.1, ENSRNOT00000080909.2

Conserved Domains (2) summary

smart00219
Location:56 → 306

TyrKc; Tyrosine kinase, catalytic domain

cd14155
Location:58 → 313

PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase