Amy2a3 amylase 2a3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Amy2a3provided by RGD
Full Name: amylase 2a3provided by RGD
Primary source: RGD:1593187
See related: Ensembl:ENSRNOG00000065221 AllianceGenome:RGD:1593187
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Amy2
Summary: Enables alpha-amylase activity. Predicted to be involved in carbohydrate catabolic process. Predicted to be located in extracellular space. Orthologous to several human genes including AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 26765.6) See more
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Genomic context

Location:: 2q42

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (204005840..204014412, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (201317916..201326487, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (216373674..216382260, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative proteomic analysis revealed that amylase levels were decreased by twofold in pancreases from hyperlipidemic rats compared with control rats.Pancreatic amylase protein levels were also decreased in tissue from hyperlipidemic rats.
Title: Hyperlipidemic versus healthy pancreases: a proteomic analysis using an animal model.
analysis of how amylase secretion is proteoglycan-dependent in rat parotid acinar cells
Title: Unstimulated amylase secretion is proteoglycan-dependent in rat parotid acinar cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Amy2 (e-PCR), detects polymorphism
- UniSTS:141077

RH134907 (e-PCR)
- UniSTS:218185

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-amylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-amylase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-amylase activity	IEA Inferred from Electronic Annotation more info
enables alpha-amylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-amylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables chloride ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pancreatic alpha-amylase

Names: 1,4-alpha-D-glucan glucanohydrolase; PA; amylase 2, pancreatic; pancreatic alpha-amylase-like; pancreatic amylase

NP_113690.2

EC 3.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031502.2 → NP_113690.2 pancreatic alpha-amylase precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P00689

UniProtKB/TrEMBL

A6HV60

Related

ENSRNOP00000083297.1, ENSRNOT00000110965.1

Conserved Domains (2) summary

cd11317
Location:25 → 413

AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)

smart00632
Location:419 → 507

Aamy_C; Aamy_C domain