Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cyp2c12provided by RGD
Full Name: cytochrome P450, family 2, subfamily c, polypeptide 12provided by RGD
Primary source: RGD:2470
See related: Ensembl:ENSRNOG00000047945 AllianceGenome:RGD:2470
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2c40; P450pb1; RATP4515B2; RATP4515B8
Summary: Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; eosinophilic esophagitis; glucose metabolism disease (multiple); invasive aspergillosis; and multiple chemical sensitivity. Orthologous to human CYP2C19 (cytochrome P450 family 2 subfamily C member 19) and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 14107.2) See more
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Genomic context

Location:: 1q53

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (248619887..248681945, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (238699859..238757011, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (258709726..258766873, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gender-related expression results from the inaccessibility of STAT5 to the GH-responsive element in male
Title: Novel gender-related regulation of CYP2C12 gene expression in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140206 (e-PCR)
- UniSTS:222285

D1Wox25 (e-PCR)
- UniSTS:118120

D1Mco26 (e-PCR)
- UniSTS:240505

RH134460 (e-PCR)
- UniSTS:217740

d1mgh29 (e-PCR)
- UniSTS:120253

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2C12, female-specific

Names: 15-beta; CYPIIC12; Cytochrom P450 15-beta; P450-UT-I; P450I; UT-1; cytochrome P450 15-beta; cytochrome P450, 2c40; cytochrome P450, family 2, subfamily c, polypeptide 40; cytochrome P450-UT-1; cytochrome P450-UT-I; cytochrome P450I

NP_113760.2

EC 1.14.14.1

XP_063137141.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031572.2 → NP_113760.2 cytochrome P450 2C12, female-specific

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P11510

UniProtKB/TrEMBL

A0A9K3Y6X0, D3Z8S1, Q64648

Related

ENSRNOP00000015802.6, ENSRNOT00000015801.8

Conserved Domains (1) summary

cd20665
Location:61 → 485

CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s