Adgrg1 adhesion G protein-coupled receptor G1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrg1provided by MGI
Official Full Name: adhesion G protein-coupled receptor G1provided by MGI
Primary source: MGI:MGI:1340051
See related: Ensembl:ENSMUSG00000031785 AllianceGenome:MGI:1340051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyt28; Gpr56; TM7LN4; TM7XN1
Summary: Enables several functions, including collagen binding activity; extracellular matrix binding activity; and heparin binding activity. Involved in several processes, including negative regulation of neuron migration; positive regulation of Rho protein signal transduction; and seminiferous tubule development. Acts upstream of or within cerebral cortex regionalization; hematopoietic stem cell homeostasis; and positive regulation of neural precursor cell proliferation. Located in glial limiting end-foot. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 93.7), ovary adult (RPKM 80.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 47.12 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95701321..95740836)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94974756..95014208)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR56 Promotes Diabetic Kidney Disease Through eNOS Regulation in Glomerular Endothelial Cells.
Title: GPR56 Promotes Diabetic Kidney Disease Through eNOS Regulation in Glomerular Endothelial Cells.
Role of GPR56 in Platelet Activation and Arterial Thrombosis.
Title: Role of GPR56 in Platelet Activation and Arterial Thrombosis.
GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
Title: GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
GPR56 S4 variant is required for microglia-mediated synaptic pruning.
Title: GPR56 S4 variant is required for microglia-mediated synaptic pruning.
Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation.
Title: Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation.
Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.
Title: Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.
Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
Title: Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo.
Title: The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo.
Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
Title: Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.
Title: A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex radial glia-guided migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in layer formation in cerebral cortex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in glial limiting end-foot	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adhesion G-protein coupled receptor G1

Names: G-protein coupled receptor 56; secretin receptor; serpentine receptor cyt28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198894.2 → NP_001185823.1 adhesion G-protein coupled receptor G1 isoform c precursor

See identical proteins and their annotated locations for NP_001185823.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC103935, AC129606

Consensus CDS

CCDS22553.1

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2

Related

ENSMUSP00000137520.2, ENSMUST00000179619.9

Conserved Domains (5) summary

cd14964
Location:403 → 427

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:345 → 388

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:29 → 162

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:173 → 220

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cl28897
Location:400 → 667

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001403764.1 → NP_001390693.1 adhesion G-protein coupled receptor G1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC103935, AC129606
NM_001403765.1 → NP_001390694.1 adhesion G-protein coupled receptor G1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC103935, AC129606
NM_001403766.1 → NP_001390695.1 adhesion G-protein coupled receptor G1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_001403767.1 → NP_001390696.1 adhesion G-protein coupled receptor G1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_001403768.1 → NP_001390697.1 adhesion G-protein coupled receptor G1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_001403769.1 → NP_001390698.1 adhesion G-protein coupled receptor G1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_001403770.1 → NP_001390699.1 adhesion G-protein coupled receptor G1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_001403771.1 → NP_001390700.1 adhesion G-protein coupled receptor G1 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_001403772.1 → NP_001390701.1 adhesion G-protein coupled receptor G1 isoform b precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_001403776.1 → NP_001390705.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935, AC129606

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403778.1 → NP_001390707.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403779.1 → NP_001390708.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403780.1 → NP_001390709.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403781.1 → NP_001390710.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403782.1 → NP_001390711.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403783.1 → NP_001390712.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403784.1 → NP_001390713.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935, AC129606

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403785.1 → NP_001390714.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935, AC129606

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403786.1 → NP_001390715.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403787.1 → NP_001390716.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403788.1 → NP_001390717.1 adhesion G-protein coupled receptor G1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC103935

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2
NM_001403789.1 → NP_001390718.1 adhesion G-protein coupled receptor G1 isoform d precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_001403790.1 → NP_001390719.1 adhesion G-protein coupled receptor G1 isoform d precursor

Status: VALIDATED

Source sequence(s)

AC103935
NM_018882.4 → NP_061370.2 adhesion G-protein coupled receptor G1 isoform c precursor

See identical proteins and their annotated locations for NP_061370.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC103935

Consensus CDS

CCDS22553.1

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2

Related

ENSMUSP00000090959.7, ENSMUST00000093271.8

Conserved Domains (5) summary

cd14964
Location:403 → 427

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:345 → 388

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:29 → 162

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:173 → 220

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cl28897
Location:400 → 667

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

95701321..95740836

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530697.3 → XP_006530760.1 adhesion G-protein coupled receptor G1 isoform X7

See identical proteins and their annotated locations for XP_006530760.1

UniProtKB/Swiss-Prot

Q3UR17, Q8K209, Q9QZT2

Conserved Domains (5) summary

cd14964
Location:403 → 427

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:345 → 388

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:29 → 162

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:173 → 220

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cl28897
Location:400 → 667

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006530691.5 → XP_006530754.1 adhesion G-protein coupled receptor G1 isoform X6

See identical proteins and their annotated locations for XP_006530754.1

Conserved Domains (5) summary

cd14964
Location:407 → 432

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:350 → 393

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:34 → 167

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:178 → 225

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cl28897
Location:405 → 672

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006530689.4 → XP_006530752.1 adhesion G-protein coupled receptor G1 isoform X6

See identical proteins and their annotated locations for XP_006530752.1

Conserved Domains (5) summary

cd14964
Location:407 → 432

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:350 → 393

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:34 → 167

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:178 → 225

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cl28897
Location:405 → 672

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017312577.2 → XP_017168066.1 adhesion G-protein coupled receptor G1 isoform X5

Conserved Domains (5) summary

cd14964
Location:415 → 440

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:358 → 401

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:42 → 175

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:186 → 233

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cl28897
Location:413 → 680

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily