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    Lrp11 low density lipoprotein receptor-related protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 237253, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lrp11provided by MGI
    Official Full Name
    low density lipoprotein receptor-related protein 11provided by MGI
    Primary source
    MGI:MGI:2442989
    See related
    Ensembl:ENSMUSG00000019796 AllianceGenome:MGI:2442989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330533B21; 1700034J19Rik; 9830160H19Rik
    Summary
    Predicted to enable phosphoprotein binding activity. Acts upstream of or within several processes, including response to cold; response to immobilization stress; and response to water deprivation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in alimentary system; nervous system; sensory organ; and smooth muscle tissue. Orthologous to human LRP11 (LDL receptor related protein 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 29.4), cortex adult (RPKM 27.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A1; 10 2.23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7465532..7501247)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7589817..7624768)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 21321 Neighboring gene UL16 binding protein 1 Neighboring gene predicted gene, 46209 Neighboring gene STARR-positive B cell enhancer ABC_E3874 Neighboring gene predicted gene 16254 Neighboring gene STARR-seq mESC enhancer starr_25682 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene RIKEN cDNA A630066F11 gene Neighboring gene STARR-positive B cell enhancer ABC_E3875 Neighboring gene nucleoporin 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic regulatory network analysis reveals that low density lipoprotein receptor-related protein 11 is involved in stress responses in mice. Xu J, et al. Psychiatry Res, 2014 Dec 30. PMID 25262641
    2. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Pereira JD, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20798045, Free PMC Article
    3. Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Osipovich AB, et al. Development, 2014 Aug. PMID 25053427, Free PMC Article
    4. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
    5. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organismal response to stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 11
    Names
    LRP-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359742.2 → NP_001346671.1  low-density lipoprotein receptor-related protein 11 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC156391, FO907139
      UniProtKB/TrEMBL
      D3Z3A7
      Conserved Domains (2) summary
      smart00765
      Location:69 → 172
      MANEC; The MANEC domain, formerly called MANSC
      smart00089
      Location:191 → 280
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins

    2. NM_001359743.2 → NP_001346672.1  low-density lipoprotein receptor-related protein 11 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC156391, FO907139
      Consensus CDS
      CCDS87955.1
      UniProtKB/TrEMBL
      D3Z2B1, D3Z3A7
      Related
      ENSMUSP00000121704.2, ENSMUST00000130590.8
      Conserved Domains (3) summary
      smart00765
      Location:69 → 172
      MANEC; The MANEC domain, formerly called MANSC
      smart00089
      Location:191 → 280
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      cd00112
      Location:294 → 328
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    3. NM_001359744.2 → NP_001346673.1  low-density lipoprotein receptor-related protein 11 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC156391, FO907139
      UniProtKB/TrEMBL
      F7AX87
      Related
      ENSMUSP00000122359.2, ENSMUST00000135907.8
      Conserved Domains (1) summary
      smart00765
      Location:69 → 172
      MANEC; The MANEC domain, formerly called MANSC

    4. NM_001379151.1 → NP_001366080.1  low-density lipoprotein receptor-related protein 11 isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AC156391, FO907139
      UniProtKB/TrEMBL
      D3Z3A7
      Related
      ENSMUSP00000122853.2, ENSMUST00000134346.8
      Conserved Domains (3) summary
      smart00765
      Location:69 → 172
      MANEC; The MANEC domain, formerly called MANSC
      smart00089
      Location:191 → 285
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      cd00112
      Location:299 → 333
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    5. NM_001379152.1 → NP_001366081.1  low-density lipoprotein receptor-related protein 11 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC156391, FO907139
      UniProtKB/TrEMBL
      D3Z3A7
      Conserved Domains (2) summary
      smart00765
      Location:69 → 172
      MANEC; The MANEC domain, formerly called MANSC
      smart00089
      Location:191 → 285
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins

    6. NM_172784.4 → NP_766372.1  low-density lipoprotein receptor-related protein 11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766372.1

      Status: VALIDATED

      Source sequence(s)
      AC156391, FO907139
      Consensus CDS
      CCDS23686.1
      UniProtKB/Swiss-Prot
      Q8C7Y7, Q8CB67
      UniProtKB/TrEMBL
      D3Z3A7
      Related
      ENSMUSP00000019931.6, ENSMUST00000019931.12
      Conserved Domains (3) summary
      smart00765
      Location:69 → 172
      MANEC; The MANEC domain, formerly called MANSC
      smart00089
      Location:191 → 280
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      cd00112
      Location:294 → 328
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      7465532..7501247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155769.1 → XP_036011662.1  low-density lipoprotein receptor-related protein 11 isoform X1

      Conserved Domains (2) summary
      smart00765
      Location:69 → 172
      MANEC; The MANEC domain, formerly called MANSC
      smart00089
      Location:191 → 285
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins

    2. XM_036155770.1 → XP_036011663.1  low-density lipoprotein receptor-related protein 11 isoform X2

      Conserved Domains (2) summary
      smart00765
      Location:69 → 172
      MANEC; The MANEC domain, formerly called MANSC
      smart00089
      Location:191 → 280
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CB67.1 GenPept UniProtKB/Swiss-Prot:Q8CB67

    Gene LinkOut

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