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    ZC3H14 zinc finger CCCH-type containing 14 [ Homo sapiens (human) ]

    Gene ID: 79882, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZC3H14provided by HGNC
    Official Full Name
    zinc finger CCCH-type containing 14provided by HGNC
    Primary source
    HGNC:HGNC:20509
    See related
    Ensembl:ENSG00000100722 MIM:613279; AllianceGenome:HGNC:20509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SUT2; MRT56; UKp68; MSUT-2; NY-REN-37
    Summary
    The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]
    Expression
    Broad expression in testis (RPKM 19.6), thyroid (RPKM 8.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q31.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88563037..88627596)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82783861..82848491)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (89029381..89093940)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370614 Neighboring gene protein tyrosine phosphatase non-receptor type 21 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89015655-89016472 Neighboring gene proline-rich protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:89084698-89085319 Neighboring gene EMAP like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8843 Neighboring gene MPRA-validated peak2226 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8844 Neighboring gene RNA, U4 small nuclear 92, pseudogene Neighboring gene tetratricopeptide repeat domain 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery. Baker JD, et al. SLAS Discov, 2021 Mar. PMID 32981422, Free PMC Article
    2. Downregulation of ZC3H14 driven by chromosome 14q31 deletion promotes hepatocellular carcinoma progression by activating integrin signaling. Zhang C, et al. Carcinogenesis, 2019 May 14. PMID 30371740
    3. The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA. Wigington CP, et al. J Biol Chem, 2016 Oct 21. PMID 27563065, Free PMC Article
    4. A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length. Kelly SM, et al. RNA, 2014 May. PMID 24671764, Free PMC Article
    5. MSUT2 is a determinant of susceptibility to tau neurotoxicity. Guthrie CR, et al. Hum Mol Genet, 2011 May 15. PMID 21355046, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery.
      Title: AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery.
    2. study suggests that ZC3H14 functions as a novel tumor suppressor and is a candidate prognostic biomarker for hepatocellular carcinoma patients
      Title: Downregulation of ZC3H14 driven by chromosome 14q31 deletion promotes hepatocellular carcinoma progression by activating integrin signaling.
    3. ATP5G1 turnover increases upon depletion of ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1, rescues ATP5G1 transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 pre-mRNA that reaches the cytoplasm when ZC3H14 is depleted and that ZC3H14 binds to ATP5G1 pre-mRNA in the nucleus.
      Title: The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.
    4. we show here that human ZC3H14 can functionally substitute for dNab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies
      Title: A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length.
    5. report a intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein
      Title: Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.
    6. MSUT2 levels may influence neuronal vulnerability to tau toxicity and aggregation.
      Title: MSUT2 is a determinant of susceptibility to tau neurotoxicity.
    7. New neuroprotective strategies targeting MSUT-2 that may be effective in modulating tau neurotoxicity in human tauopathy disorders.
      Title: The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?
    8. multiple transcripts encoding several ZC3H14 isoforms exist in vivo
      Title: Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein.
    9. these proteins are members of an evolutionarily conserved family of poly(A) RNA binding proteins
      Title: Recognition of polyadenosine RNA by zinc finger proteins.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, autosomal recessive 56
    MedGen: C4310703 OMIM: 617125 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11806, MGC26892

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 14
    Names
    mammalian suppressor of tau pathology-2
    nuclear protein UKp68
    renal carcinoma antigen NY-REN-37

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050601.2 RefSeqGene

      Range
      5002..69561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001160103.2 → NP_001153575.1  zinc finger CCCH domain-containing protein 14 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (5) lacks one-aa near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AL162171, AL359625, BC011793, BC023641, BC034274, BX248769, DB452844
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:621 → 639
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    2. NM_001160104.2 → NP_001153576.1  zinc finger CCCH domain-containing protein 14 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. The resulting isoform (6) lacks a five-aa and a one-aa segment, compared to isoform 1.
      Source sequence(s)
      AK304275, AL162171, AL359625, BC011793, BC034274, BX248769, DB452844
      Consensus CDS
      CCDS55938.1
      UniProtKB/TrEMBL
      H0YJA2
      Related
      ENSP00000452475.1, ENST00000555755.5
      Conserved Domains (1) summary
      pfam14608
      Location:616 → 634
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    3. NM_001326295.2 → NP_001313224.1  zinc finger CCCH domain-containing protein 14 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Consensus CDS
      CCDS86417.1
      UniProtKB/TrEMBL
      G3V256
      Related
      ENSP00000450474.1, ENST00000556945.5
      Conserved Domains (1) summary
      pfam14608
      Location:551 → 567
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    4. NM_001326296.2 → NP_001313225.1  zinc finger CCCH domain-containing protein 14 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2

    5. NM_001326297.2 → NP_001313226.1  zinc finger CCCH domain-containing protein 14 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:587 → 605
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    6. NM_001326298.2 → NP_001313227.1  zinc finger CCCH domain-containing protein 14 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Conserved Domains (1) summary
      pfam14608
      Location:526 → 542
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    7. NM_001326299.2 → NP_001313228.1  zinc finger CCCH domain-containing protein 14 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2

    8. NM_001326300.2 → NP_001313229.1  zinc finger CCCH domain-containing protein 14 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:527 → 543
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    9. NM_001326301.2 → NP_001313230.1  zinc finger CCCH domain-containing protein 14 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2

    10. NM_001326302.2 → NP_001313231.1  zinc finger CCCH domain-containing protein 14 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Related
      ENSP00000451054.1, ENST00000556000.5
      Conserved Domains (1) summary
      pfam14608
      Location:526 → 542
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    11. NM_001326303.2 → NP_001313232.1  zinc finger CCCH domain-containing protein 14 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Conserved Domains (1) summary
      pfam14608
      Location:491 → 507
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    12. NM_001326304.2 → NP_001313233.1  zinc finger CCCH domain-containing protein 14 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      G3V5I6

    13. NM_001326305.2 → NP_001313234.1  zinc finger CCCH domain-containing protein 14 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:502 → 518
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    14. NM_001326306.2 → NP_001313235.1  zinc finger CCCH domain-containing protein 14 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Conserved Domains (1) summary
      pfam14608
      Location:473 → 489
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    15. NM_001326307.2 → NP_001313236.1  zinc finger CCCH domain-containing protein 14 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Consensus CDS
      CCDS86418.1
      UniProtKB/TrEMBL
      H0YJA2
      Related
      ENSP00000377150.5, ENST00000393514.9
      Conserved Domains (1) summary
      pfam14608
      Location:596 → 614
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    16. NM_001326308.2 → NP_001313237.1  zinc finger CCCH domain-containing protein 14 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      G3V5I6

    17. NM_001326309.2 → NP_001313238.1  zinc finger CCCH domain-containing protein 14 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      G3V5I6

    18. NM_001326310.2 → NP_001313239.1  zinc finger CCCH domain-containing protein 14 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:616 → 634
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    19. NM_001326311.2 → NP_001313240.1  zinc finger CCCH domain-containing protein 14 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      G3V5I6
      Related
      ENSP00000452370.1, ENST00000557607.5

    20. NM_001326312.2 → NP_001313241.1  zinc finger CCCH domain-containing protein 14 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2

    21. NM_001326313.2 → NP_001313242.1  zinc finger CCCH domain-containing protein 14 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Conserved Domains (1) summary
      pfam14608
      Location:474 → 490
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    22. NM_001326314.2 → NP_001313243.1  zinc finger CCCH domain-containing protein 14 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:501 → 517
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    23. NM_001326315.2 → NP_001313244.1  zinc finger CCCH domain-containing protein 14 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) and variant 28 both encode the same isoform (27).
      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2

    24. NM_001326316.2 → NP_001313245.1  zinc finger CCCH domain-containing protein 14 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28) and variant 27 both encode the same isoform (27).
      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2

    25. NM_024824.5 → NP_079100.2  zinc finger CCCH domain-containing protein 14 isoform 1

      See identical proteins and their annotated locations for NP_079100.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL162171, AL359625, BC011793, BC034274, BX248769, DB452844
      Consensus CDS
      CCDS32133.1
      UniProtKB/Swiss-Prot
      A8MY46, B4DXU8, B4DZW7, B4E2H4, G3V5R4, Q6MZU4, Q6PJ32, Q6PJT7, Q6PUI6, Q6PUI8, Q86TQ5, Q86TW0, Q86TW1, Q8NCT6, Q8NCZ3, Q8TDE2, Q9HAC9, Q9Y5A0
      UniProtKB/TrEMBL
      H0YJA2
      Related
      ENSP00000251038.5, ENST00000251038.10
      Conserved Domains (1) summary
      pfam14608
      Location:621 → 639
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    26. NM_207660.4 → NP_997543.1  zinc finger CCCH domain-containing protein 14 isoform 2

      See identical proteins and their annotated locations for NP_997543.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three alternate exons in the central coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment and one-aa near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AL162171, AL359625, AY578061, BC034274, BX248769
      Consensus CDS
      CCDS32134.1
      UniProtKB/Swiss-Prot
      Q6PJT7
      Related
      ENSP00000307025.8, ENST00000302216.12

    27. NM_207661.3 → NP_997544.1  zinc finger CCCH domain-containing protein 14 isoform 3

      See identical proteins and their annotated locations for NP_997544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter, uses a downstream start codon, and lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF474376, AL162171, AY578062, BC034274, BX248769
      Consensus CDS
      CCDS32135.1
      UniProtKB/Swiss-Prot
      Q6PJT7
      Related
      ENSP00000338002.4, ENST00000336693.8
      Conserved Domains (1) summary
      pfam14608
      Location:517 → 533
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    28. NM_207662.4 → NP_997545.2  zinc finger CCCH domain-containing protein 14 isoform 4

      See identical proteins and their annotated locations for NP_997545.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter, lacks two alternate exons in the central coding region, and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, and lacks an internal segment and one-aa near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AL162171, AL359625, BC027607, BC034274, BX248769, DB050247
      Consensus CDS
      CCDS32136.1
      UniProtKB/Swiss-Prot
      Q6PJT7
      Related
      ENSP00000327176.6, ENST00000318308.10
      Conserved Domains (1) summary
      pfam14608
      Location:252 → 268
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    RNA

    1. NR_136936.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL162171

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      88563037..88627596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537162.4 → XP_011535464.1  zinc finger CCCH domain-containing protein 14 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      82783861..82848491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376723.1 → XP_054232698.1  zinc finger CCCH domain-containing protein 14 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PJT7.1 GenPept UniProtKB/Swiss-Prot:Q6PJT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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