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    TRPC1 transient receptor potential cation channel subfamily C member 1 [ Homo sapiens (human) ]

    Gene ID: 7220, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TRPC1provided by HGNC
    Official Full Name
    transient receptor potential cation channel subfamily C member 1provided by HGNC
    Primary source
    HGNC:HGNC:12333
    See related
    Ensembl:ENSG00000144935 MIM:602343; AllianceGenome:HGNC:12333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRP1; HTRP-1
    Summary
    The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.9) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (142724034..142807888)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (145471273..145555131)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142442876..142526730)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20645 Neighboring gene PLS1 antisense RNA 1 Neighboring gene plastin 1 Neighboring gene RN7SK pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14790 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:142443428-142444294 Neighboring gene Sharpr-MPRA regulatory region 6947 Neighboring gene RNA, U7 small nuclear 47 pseudogene Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene ribosomal protein L8 pseudogene 3 Neighboring gene uncharacterized LOC124909443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14791

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Function of TRPC1 in modulating hepatocellular carcinoma progression. Qi H, et al. Med Oncol, 2023 Feb 16. PMID 36797544
    2. The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner. Schnipper J, et al. Int J Mol Sci, 2022 Jul 18. PMID 35887266, Free PMC Article
    3. Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients. Ke C, et al. J Clin Lab Anal, 2022 Mar. PMID 35106847, Free PMC Article
    4. Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1. Yart L, et al. J Cell Physiol, 2022 Mar. PMID 34988986, Free PMC Article
    5. Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension. Zhang Y, et al. Clin Exp Hypertens, 2021 Jul 4. PMID 33877007

    See all (196) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of TRPC1 protects against high glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
      Title: Upregulation of TRPC1 protects against high glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
    2. Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling protects oxidative stress-induced COPD.
      Title: Reduction of TRPC1/TRPC3 mediated Ca(2+)-signaling protects oxidative stress-induced COPD.
    3. Function of TRPC1 in modulating hepatocellular carcinoma progression.
      Title: Function of TRPC1 in modulating hepatocellular carcinoma progression.
    4. TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation.
      Title: TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation.
    5. NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/beta-catenin pathway.
      Title: NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/β-catenin pathway.
    6. The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner.
      Title: The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner.
    7. Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.
      Title: Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.
    8. Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients.
      Title: Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients.
    9. Orai1alpha, but not Orai1beta, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.
      Title: Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.
    10. Sigma1 Receptor Inhibits TRPC1-Mediated Ca(2+) Entry That Promotes Dopaminergic Cell Death.
      Title: Sigma1 Receptor Inhibits TRPC1-Mediated Ca(2+) Entry That Promotes Dopaminergic Cell Death.
    Submit: New GeneRIF Correction See all GeneRIFs (160)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat PI3K/Akt, TRPC, and GSK3 beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133334, MGC133335

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calcium channel activity TAS
    Traceable Author Statement
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in calcium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in melanin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cardiac conduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    short transient receptor potential channel 1
    Names
    capacitative calcium channel protein Trp1
    transient receptor potential canonical 1
    transient receptor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030369.1 RefSeqGene

      Range
      4611..88465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001251845.2 → NP_001238774.1  short transient receptor potential channel 1 isoform 1

      See identical proteins and their annotated locations for NP_001238774.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC072028, AI280444, BC112338, X89066
      Consensus CDS
      CCDS58856.1
      UniProtKB/Swiss-Prot
      P48995, Q14CE4
      UniProtKB/TrEMBL
      A7VJS2
      Related
      ENSP00000419313.1, ENST00000476941.6
      Conserved Domains (1) summary
      TIGR00870
      Location:48 → 774
      trp; transient-receptor-potential calcium channel protein

    2. NM_001413361.1 → NP_001400290.1  short transient receptor potential channel 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    3. NM_001413362.1 → NP_001400291.1  short transient receptor potential channel 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    4. NM_001413363.1 → NP_001400292.1  short transient receptor potential channel 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    5. NM_001413375.1 → NP_001400304.1  short transient receptor potential channel 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    6. NM_001413376.1 → NP_001400305.1  short transient receptor potential channel 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    7. NM_001413377.1 → NP_001400306.1  short transient receptor potential channel 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    8. NM_001413378.1 → NP_001400307.1  short transient receptor potential channel 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    9. NM_001413379.1 → NP_001400308.1  short transient receptor potential channel 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    10. NM_001413380.1 → NP_001400309.1  short transient receptor potential channel 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    11. NM_001413381.1 → NP_001400310.1  short transient receptor potential channel 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    12. NM_001413382.1 → NP_001400311.1  short transient receptor potential channel 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    13. NM_001413383.1 → NP_001400312.1  short transient receptor potential channel 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    14. NM_001413384.1 → NP_001400313.1  short transient receptor potential channel 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    15. NM_001413385.1 → NP_001400314.1  short transient receptor potential channel 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    16. NM_001413386.1 → NP_001400315.1  short transient receptor potential channel 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC022291, AC072028

    17. NM_003304.5 → NP_003295.1  short transient receptor potential channel 1 isoform 2

      See identical proteins and their annotated locations for NP_003295.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC072028, BX331349, DB185459, X89066
      Consensus CDS
      CCDS3126.1
      UniProtKB/TrEMBL
      A7VJS2
      Related
      ENSP00000273482.6, ENST00000273482.10
      Conserved Domains (2) summary
      TIGR00870
      Location:48 → 740
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:83 → 117
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      142724034..142807888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448842.1 → XP_047304798.1  short transient receptor potential channel 1 isoform X5

    2. XM_047448840.1 → XP_047304796.1  short transient receptor potential channel 1 isoform X3

    3. XM_047448841.1 → XP_047304797.1  short transient receptor potential channel 1 isoform X4

    4. XM_017007121.3 → XP_016862610.1  short transient receptor potential channel 1 isoform X1

      UniProtKB/TrEMBL
      A7VJS2
      Conserved Domains (1) summary
      TIGR00870
      Location:2 → 713
      trp; transient-receptor-potential calcium channel protein

    5. XM_047448839.1 → XP_047304795.1  short transient receptor potential channel 1 isoform X2

    RNA

    1. XR_007095723.1 RNA Sequence

    2. XR_007095722.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      145471273..145555131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347736.1 → XP_054203711.1  short transient receptor potential channel 1 isoform X5

    2. XM_054347734.1 → XP_054203709.1  short transient receptor potential channel 1 isoform X3

    3. XM_054347735.1 → XP_054203710.1  short transient receptor potential channel 1 isoform X4

    4. XM_054347732.1 → XP_054203707.1  short transient receptor potential channel 1 isoform X1

    5. XM_054347733.1 → XP_054203708.1  short transient receptor potential channel 1 isoform X2

    RNA

    1. XR_008486788.1 RNA Sequence

    2. XR_008486787.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48995.1 GenPept UniProtKB/Swiss-Prot:P48995

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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