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    Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 [ Mus musculus (house mouse) ]

    Gene ID: 229279, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hnrnpa3provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A3provided by MGI
    Primary source
    MGI:MGI:1917171
    See related
    Ensembl:ENSMUSG00000059005 AllianceGenome:MGI:1917171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpa3; 2410013L13Rik; 2610209F03Rik; 2610510D13Rik
    Summary
    Predicted to enable RNA transmembrane transporter activity and mRNA binding activity. Predicted to be involved in mRNA transport. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in several cellular components, including neuron projection; nucleoplasm; and ribonucleoprotein granule. Predicted to be part of catalytic step 2 spliceosome and messenger ribonucleoprotein complex. Is expressed in central nervous system and sensory organ. Orthologous to human HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 167.7), liver E14 (RPKM 103.2) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C3; 2 44.75 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (75489416..75499751)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (75659105..75669407)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04864 Neighboring gene predicted gene, 39858 Neighboring gene predicted gene, 39859 Neighboring gene STARR-seq mESC enhancer starr_04867 Neighboring gene STARR-seq mESC enhancer starr_04869 Neighboring gene nuclear factor, erythroid derived 2, like 2 Neighboring gene RIKEN cDNA E030042O20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1590 Neighboring gene STARR-positive B cell enhancer ABC_E4469

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HnRNP A3 binds to and protects mammalian telomeric repeats in vitro. Tanaka E, et al. Biochem Biophys Res Commun, 2007 Jun 29. PMID 17502110
    2. Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals. Papadopoulou C, et al. Arch Biochem Biophys, 2012 Jul 15. PMID 22546510
    3. Heterogeneous nuclear ribonucleoprotein A3 is the liver nuclear protein binding to age related increase element RNA of the factor IX gene. Hamada T, et al. PLoS One, 2010 Sep 24. PMID 20885981, Free PMC Article
    4. HnRNP A3 genes and pseudogenes in the vertebrate genomes. Makeyev AV, et al. J Exp Zool A Comp Exp Biol, 2005 Apr 1. PMID 15776420
    5. Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin. Ou MY, et al. Development, 2020 May 15. PMID 32321712

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.
      Title: Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.
    2. characterization of hnRNP A3 in human and mouse cell lines
      Title: Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals.
    3. hnRNP A3 is a major liver nuclear protein binding to age related increase element of the factor IX gene.
      Title: Heterogeneous nuclear ribonucleoprotein A3 is the liver nuclear protein binding to age related increase element RNA of the factor IX gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37309, MGC101940, 2410013L13Rik, 2610209F03Rik, 2610510D13Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein A3
    Names
    hnRNP A3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359971.1 → NP_001346900.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL772404
      Consensus CDS
      CCDS50610.1
      UniProtKB/TrEMBL
      B2RXM2, Q0VG47
      Related
      ENSMUSP00000126069.3, ENSMUST00000164947.9
      Conserved Domains (3) summary
      pfam11627
      Location:310 → 326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12582
      Location:104 → 183
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
      cd12763
      Location:11 → 91
      RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

    2. NM_053263.1 → NP_444493.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

      See identical proteins and their annotated locations for NP_444493.1

      Status: VALIDATED

      Source sequence(s)
      AB201711, AF463524, AK011930, AK076236, BC038364, BC085474, CJ048391, CJ048901
      Consensus CDS
      CCDS50610.1
      UniProtKB/TrEMBL
      B2RXM2, Q0VG47
      Related
      ENSMUSP00000107593.2, ENSMUST00000111962.8
      Conserved Domains (3) summary
      pfam11627
      Location:310 → 326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12582
      Location:104 → 183
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
      cd12763
      Location:11 → 91
      RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

    3. NM_146130.3 → NP_666242.2  heterogeneous nuclear ribonucleoprotein A3 isoform a

      See identical proteins and their annotated locations for NP_666242.2

      Status: VALIDATED

      Source sequence(s)
      AK011930, AK076236, AK133860, BC038364, BC085474, CJ048391, CO045618
      Consensus CDS
      CCDS16149.1
      UniProtKB/Swiss-Prot
      Q8BG05, Q8BHF8
      UniProtKB/TrEMBL
      Q3UZG3, Q5FB19
      Related
      ENSMUSP00000107595.2, ENSMUST00000111964.8
      Conserved Domains (3) summary
      pfam11627
      Location:332 → 348
      HnRNPA1; Nuclear factor hnRNPA1
      cd12578
      Location:36 → 113
      RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cd12582
      Location:126 → 205
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

    4. NM_198090.2 → NP_932758.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

      See identical proteins and their annotated locations for NP_932758.1

      Status: VALIDATED

      Source sequence(s)
      BC038364, CJ048391, CJ048901
      Consensus CDS
      CCDS16149.1
      UniProtKB/Swiss-Prot
      Q8BG05, Q8BHF8
      UniProtKB/TrEMBL
      Q3UZG3, Q5FB19
      Related
      ENSMUSP00000088298.5, ENSMUST00000090792.11
      Conserved Domains (3) summary
      pfam11627
      Location:332 → 348
      HnRNPA1; Nuclear factor hnRNPA1
      cd12578
      Location:36 → 113
      RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cd12582
      Location:126 → 205
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      75489416..75499751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940316.1 RNA Sequence

    2. XR_866271.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG05.1 GenPept UniProtKB/Swiss-Prot:Q8BG05

    Gene LinkOut

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