arhgap12a Rho GTPase activating protein 12a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arhgap12aprovided by ZNC
Official Full Name: Rho GTPase activating protein 12aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050809-38
See related: Ensembl:ENSDARG00000008548 AllianceGenome:ZFIN:ZDB-GENE-050809-38
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7153489; si:ch211-159p3.3
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Is expressed in ectoderm. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (43749187..43797223)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (43896185..43944225)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell development	IEA Inferred from Electronic Annotation more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho GTPase activating protein 12a; rho GTPase-activating protein 12a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126407.1 → NP_001119879.1 rho GTPase-activating protein 12a

Status: PROVISIONAL

Source sequence(s)

CR457482

UniProtKB/TrEMBL

A0A8M1NHD5, F6P057

Related

ENSDARP00000122140.1, ENSDART00000142804.3

Conserved Domains (6) summary

cd12070
Location:11 → 70

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:638 → 824

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:448 → 558

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:462 → 559

PH; PH domain

pfam00397
Location:252 → 278

WW; WW domain

pfam16618
Location:67 → 233

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

43749187..43797223

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480748.1 → XP_021336423.1 rho GTPase activating protein 12a isoform X1

UniProtKB/TrEMBL

A0A8M9QA49

Conserved Domains (5) summary

cd12070
Location:11 → 70

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:660 → 846

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:470 → 580

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:252 → 278

WW; WW domain

pfam16618
Location:67 → 233

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_005171385.4 → XP_005171442.1 rho GTPase activating protein 12a isoform X2

UniProtKB/TrEMBL

A0A8M2BIT3

Conserved Domains (6) summary

cd12070
Location:11 → 70

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:632 → 818

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:442 → 552

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:456 → 553

PH; PH domain

pfam00397
Location:252 → 278

WW; WW domain

pfam16618
Location:67 → 233

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_021480763.1 → XP_021336438.1 rho GTPase activating protein 12a isoform X3

UniProtKB/TrEMBL

A0A8M9QA59

Conserved Domains (5) summary

cd12070
Location:11 → 70

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:616 → 802

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:426 → 536

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:252 → 278

WW; WW domain

pfam16618
Location:67 → 233

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_021480770.1 → XP_021336445.1 rho GTPase activating protein 12a isoform X6

UniProtKB/TrEMBL

A0A8M9QNP2

Conserved Domains (5) summary

cd12070
Location:11 → 70

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:583 → 769

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:393 → 503

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:252 → 278

WW; WW domain

pfam16618
Location:67 → 233

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_005171386.4 → XP_005171443.1 rho GTPase activating protein 12a isoform X4

UniProtKB/TrEMBL

A0A8M2BIQ0

Conserved Domains (6) summary

cd12070
Location:11 → 70

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:610 → 796

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:420 → 530

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:434 → 531

PH; PH domain

pfam00397
Location:252 → 278

WW; WW domain

pfam16618
Location:67 → 233

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_005171388.4 → XP_005171445.1 rho GTPase activating protein 12a isoform X5

UniProtKB/TrEMBL

A0A8M2BJ65

Conserved Domains (6) summary

cd12070
Location:11 → 70

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:588 → 774

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:398 → 508

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:412 → 509

PH; PH domain

pfam00397
Location:252 → 278

WW; WW domain

pfam16618
Location:67 → 233

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_021480754.1 → XP_021336429.1 rho GTPase activating protein 12a isoform X1

UniProtKB/TrEMBL

A0A8M9QA49

Conserved Domains (5) summary

cd12070
Location:11 → 70

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:660 → 846

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:470 → 580

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:252 → 278

WW; WW domain

pfam16618
Location:67 → 233

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_021480772.1 → XP_021336447.1 rho GTPase activating protein 12a isoform X7

UniProtKB/TrEMBL

A0A8M9PYG1

Conserved Domains (4) summary

cd04403
Location:455 → 641

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:265 → 375

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:47 → 73

WW; WW domain

pfam16618
Location:10 → 28

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_021480774.1 → XP_021336449.1 rho GTPase activating protein 12a isoform X8

UniProtKB/TrEMBL

A0A8M9QFU9

Conserved Domains (4) summary

cd04403
Location:433 → 619

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:243 → 353

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:47 → 73

WW; WW domain

pfam16618
Location:10 → 28

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12