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    MMP26 matrix metallopeptidase 26 [ Homo sapiens (human) ]

    Gene ID: 56547, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MMP26provided by HGNC
    Official Full Name
    matrix metallopeptidase 26provided by HGNC
    Primary source
    HGNC:HGNC:14249
    See related
    Ensembl:ENSG00000167346 MIM:605470; AllianceGenome:HGNC:14249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]
    Expression
    Restricted expression toward endometrium (RPKM 7.9) See more
    Orthologs
    all
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    Genomic context

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    Location:
    11p15.4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (4704784..4992429)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (4770289..5049368)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4726014..5013659)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376528 Neighboring gene olfactory receptor family 51 subfamily E member 2 Neighboring gene olfactory receptor family 51 subfamily C member 1 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 5 pseudogene Neighboring gene olfactory receptor family 51 subfamily C member 4 pseudogene Neighboring gene keratin 8 pseudogene 49 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene olfactory receptor family 51 subfamily F member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 4 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 1 Neighboring gene olfactory receptor family 51 subfamily N member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily Y member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily R member 1 Neighboring gene olfactory receptor family 51 subfamily F member 2 Neighboring gene olfactory receptor family 51 subfamily A member 8 pseudogene Neighboring gene olfactory receptor family 51 subfamily S member 1 Neighboring gene olfactory receptor family 51 subfamily H member 1 Neighboring gene olfactory receptor family 51 subfamily H member 2 pseudogene Neighboring gene olfactory receptor family 51 subfamily T member 1 Neighboring gene olfactory receptor family 51 subfamily A member 6 pseudogene Neighboring gene olfactory receptor family 51 subfamily A member 7 Neighboring gene olfactory receptor family 51 subfamily G member 2 Neighboring gene olfactory receptor family 51 subfamily G member 1 Neighboring gene olfactory receptor family 51 subfamily A member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily A member 4 Neighboring gene olfactory receptor family 51 subfamily A member 2 Neighboring gene olfactory receptor family 51 subfamily A member 5 pseudogene Neighboring gene olfactory receptor family 51 subfamily L member 1 Neighboring gene olfactory receptor family 51 subfamily P member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MMP26: A potential biomarker for prostate cancer. Cheng T, et al. J Huazhong Univ Sci Technolog Med Sci, 2017 Dec. PMID 29270749
    2. Regulation of chondrosarcoma invasion by MMP26. Xu X, et al. Tumour Biol, 2015 Jan. PMID 25262277
    3. Matrilysin-2 expression in colorectal cancer is associated with overall survival of patients. Hu Q, et al. Tumour Biol, 2014 Apr. PMID 24318970
    4. Estrogen and estrogen receptor induce matrix metalloproteinase-26 expression in endometrial carcinoma cells. Nishi H, et al. Oncol Rep, 2013 Aug. PMID 23754174
    5. GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expression. Gutschalk CM, et al. Cancer Med, 2013 Apr. PMID 23634280, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MMP26 is overexpressed in prostatic neoplasms patients, and can serve as a serum disease biomarker.
      Title: MMP26: A potential biomarker for prostate cancer.
    2. The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro.
      Title: MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day.
    3. MMP26+CXCR4+ cells may be circulating tumor cells in hepatocellular carcinoma.
      Title: Circulating Hepatocellular Carcinoma Cells are Characterized by CXCR4 and MMP26.
    4. We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer
      Title: Activation of FGF receptor signaling promotes invasion of non-small-cell lung cancer.
    5. Overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness.
      Title: Regulation of chondrosarcoma invasion by MMP26.
    6. The binding of MMP-26 to GDF15 was responsible for the processing and maturation of pro-GDF15, and the process was dependent on enzymatic activity of MMP-26. In human placental trophoblast cells, MMP-26 could facilitate the pro-apoptotic effect of GDF15.
      Title: Maturation of growth differentiation factor 15 in human placental trophoblast cells depends on the interaction with Matrix Metalloproteinase-26.
    7. matrilysin-2 was an independent prognostic marker for patients with colorectal cancer
      Title: Matrilysin-2 expression in colorectal cancer is associated with overall survival of patients.
    8. These results demonstrate that the HOXA10-mediated expression of MMP-26 promotes embryo adhesion during the process of embryonic implantation.
      Title: Activation of matrix metalloproteinase-26 by HOXA10 promotes embryo adhesion in vitro.
    9. The MMP-26 promoter region contains a putative ER response element.
      Title: Estrogen and estrogen receptor induce matrix metalloproteinase-26 expression in endometrial carcinoma cells.
    10. expression of MMP-26 protein was predominantly located in pre- and early-invasive areas suggesting MMP-26 expression as an early event in promoting GM-CSF dependent tumor invasion.
      Title: GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126590, MGC126592

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    matrix metalloproteinase-26
    Names
    MMP-26
    endometase
    matrilysin 2
    NP_001371537.1
    NP_068573.2
    XP_011518521.1
    XP_054225330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384608.1 → NP_001371537.1  matrix metalloproteinase-26 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC018375, AC090719, AC103710
      Consensus CDS
      CCDS91424.1
      UniProtKB/TrEMBL
      A0A8J8YUH5
      Related
      ENSP00000300762.2, ENST00000300762.2
      Conserved Domains (1) summary
      pfam00413
      Location:28 → 183
      Peptidase_M10; Matrixin

    2. NM_021801.5 → NP_068573.2  matrix metalloproteinase-26 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_068573.2

      Status: REVIEWED

      Source sequence(s)
      AC018375, AC090719, AC103710
      Consensus CDS
      CCDS7752.1
      UniProtKB/Swiss-Prot
      Q3MJ78, Q9GZS2, Q9NR87, Q9NRE1
      Related
      ENSP00000369753.1, ENST00000380390.6
      Conserved Domains (1) summary
      pfam00413
      Location:98 → 253
      Peptidase_M10; Matrixin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      4704784..4992429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520219.3 → XP_011518521.1  matrix metalloproteinase-26 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YUH5
      Conserved Domains (1) summary
      pfam00413
      Location:28 → 183
      Peptidase_M10; Matrixin

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      4770289..5049368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369355.1 → XP_054225330.1  matrix metalloproteinase-26 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YUH5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRE1.2 GenPept UniProtKB/Swiss-Prot:Q9NRE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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