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    ZNF277 zinc finger protein 277 [ Homo sapiens (human) ]

    Gene ID: 11179, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZNF277provided by HGNC
    Official Full Name
    zinc finger protein 277provided by HGNC
    Primary source
    HGNC:HGNC:13070
    See related
    Ensembl:ENSG00000198839 MIM:605465; AllianceGenome:HGNC:13070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRIF4; ZNF277P
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and metal ion binding activity. Predicted to act upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Note: Although this gene is named as a pseudogene, it is not yet established that the truncated protein lost function (PubMed 16395595). The NCBI RefSeq Project therefore continues to treat this as a protein coding gene. [11 Apr 2007]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.6), urinary bladder (RPKM 6.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q31.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (112206695..112343934)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (113525002..113662218)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (111846750..111983989)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:111602884-111603668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:111603669-111604451 Neighboring gene RNA, 5S ribosomal pseudogene 237 Neighboring gene ribosomal protein L7a pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26509 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:111767901-111768536 Neighboring gene NANOG hESC enhancer GRCh37_chr7:111802020-111802560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26510 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:111892650-111893231 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:111905044-111905648 Neighboring gene RN7SK pseudogene 187 Neighboring gene ZNF277 antisense RNA 1 Neighboring gene uncharacterized LOC105375456 Neighboring gene MT-ND6 pseudogene 24 Neighboring gene MT-ND5 pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment. Ceroni F, et al. Eur J Hum Genet, 2014 Oct. PMID 24518835, Free PMC Article
    2. Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms. Liang H, et al. Cancer Genet Cytogenet, 2005 Oct 15. PMID 16213364
    3. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. Liang H, et al. Genomics, 2000 Jun 1. PMID 10860669
    4. The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction. Dionne KL, et al. J Biol Chem, 2019 Feb 8. PMID 30530495, Free PMC Article
    5. Human-specific nonsense mutations identified by genome sequence comparisons. Hahn Y, et al. Hum Genet, 2006 Mar. PMID 16395595

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF277 and PRMT3 compete for uS5 binding, because overexpression of PRMT3 inhibited the formation of the ZNF277-uS5 complex, whereas depletion of cellular ZNF277 resulted in increased levels of uS5-PRMT3.
      Title: The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction.
    2. ZNF277 microdeletions might contribute to the risk of language impairments
      Title: Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 277 (ZNF277) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 277
    Names
    nuclear receptor-interacting factor 4
    zinc finger protein (C2H2 type) 277
    zinc finger protein 277 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041797.1 RefSeqGene

      Range
      5108..142347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021994.3 → NP_068834.2  zinc finger protein 277

      See identical proteins and their annotated locations for NP_068834.2

      Status: VALIDATED

      Source sequence(s)
      AF209198, BG924796, DA285525, DB543718
      Consensus CDS
      CCDS5755.2
      UniProtKB/Swiss-Prot
      Q75MZ2, Q75MZ3, Q8WY14, Q9NRM2
      UniProtKB/TrEMBL
      A4D0S7
      Related
      ENSP00000354501.3, ENST00000361822.8
      Conserved Domains (2) summary
      sd00020
      Location:226 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:175 → 262
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      112206695..112343934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515768.4 → XP_011514070.1  zinc finger protein 277 isoform X1

      See identical proteins and their annotated locations for XP_011514070.1

      UniProtKB/TrEMBL
      A4D0S7
      Conserved Domains (2) summary
      sd00020
      Location:148 → 170
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:97 → 184
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    2. XM_017011720.3 → XP_016867209.1  zinc finger protein 277 isoform X2

      Conserved Domains (2) summary
      sd00020
      Location:108 → 130
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:57 → 144
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      113525002..113662218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357167.1 → XP_054213142.1  zinc finger protein 277 isoform X1

    2. XM_054357168.1 → XP_054213143.1  zinc finger protein 277 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRM2.2 GenPept UniProtKB/Swiss-Prot:Q9NRM2

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