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    Dmrtb1 DMRT-like family B with proline-rich C-terminal, 1 [ Mus musculus (house mouse) ]

    Gene ID: 56296, updated on 12-May-2024

    Summary

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    Official Symbol
    Dmrtb1provided by MGI
    Official Full Name
    DMRT-like family B with proline-rich C-terminal, 1provided by MGI
    Primary source
    MGI:MGI:1927125
    See related
    Ensembl:ENSMUSG00000028610 AllianceGenome:MGI:1927125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dmrt6; Prp13
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in germ cell development; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to be active in nucleus. Is expressed in brain and testis. Orthologous to human DMRTB1 (DMRT like family B with proline rich C-terminal 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 254.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C7; 4 50.18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107533485..107561208, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107676288..107704011, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene GLIS family zinc finger 1 Neighboring gene RIKEN cDNA 4930552P06 gene Neighboring gene predicted gene, 52673 Neighboring gene STARR-seq mESC enhancer starr_11025 Neighboring gene RIKEN cDNA 1700047F07 gene Neighboring gene STARR-seq mESC enhancer starr_11026 Neighboring gene predicted gene 12899 Neighboring gene predicted gene, 57502 Neighboring gene translocase of outer mitochondrial membrane 22 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis. Zhang T, et al. Development, 2014 Oct. PMID 25249458, Free PMC Article
    2. Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. Poulain M, et al. Mol Hum Reprod, 2014 Oct. PMID 25082981
    3. The function of Dmrt genes in vertebrate development: it is not just about sex. Hong CS, et al. Dev Biol, 2007 Oct 1. PMID 17720152
    4. Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad. Kim S, et al. Gene Expr Patterns, 2003 Mar. PMID 12609607
    5. Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2. Ono K, et al. Commun Biol, 2021 Mar 11. PMID 33707608, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.
      Title: The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables sequence-specific DNA binding IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    doublesex- and mab-3-related transcription factor B1
    Names
    doublesex and mab-3 related transcription factor 6
    proline-rich protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019872.3 → NP_063925.1  doublesex- and mab-3-related transcription factor B1

      See identical proteins and their annotated locations for NP_063925.1

      Status: VALIDATED

      Source sequence(s)
      AL627259
      Consensus CDS
      CCDS51254.1
      UniProtKB/Swiss-Prot
      A2A9I7, Q8CGW8
      Related
      ENSMUSP00000064220.5, ENSMUST00000069271.5
      Conserved Domains (1) summary
      pfam00751
      Location:3 → 49
      DM; DM DNA binding domain

    RNA

    1. NR_151717.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627259
      Related
      ENSMUST00000131776.8

    2. NR_188989.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627259

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107533485..107561208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253681.1 → XP_030109541.1  doublesex- and mab-3-related transcription factor B1 isoform X1

      UniProtKB/Swiss-Prot
      A2A9I7, Q8CGW8
      Conserved Domains (1) summary
      pfam00751
      Location:3 → 49
      DM; DM DNA binding domain

    2. XM_036164258.1 → XP_036020151.1  doublesex- and mab-3-related transcription factor B1 isoform X2

      Conserved Domains (1) summary
      pfam00751
      Location:3 → 49
      DM; DM DNA binding domain

    3. XM_036164257.1 → XP_036020150.1  doublesex- and mab-3-related transcription factor B1 isoform X1

      UniProtKB/Swiss-Prot
      A2A9I7, Q8CGW8
      Conserved Domains (1) summary
      pfam00751
      Location:3 → 49
      DM; DM DNA binding domain

    4. XM_030253682.1 → XP_030109542.1  doublesex- and mab-3-related transcription factor B1 isoform X3

      UniProtKB/TrEMBL
      O35315
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A9I7.1 GenPept UniProtKB/Swiss-Prot:A2A9I7

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