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    RPS6KL1 ribosomal protein S6 kinase like 1 [ Homo sapiens (human) ]

    Gene ID: 83694, updated on 3-Apr-2024

    Summary

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    Official Symbol
    RPS6KL1provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase like 1provided by HGNC
    Primary source
    HGNC:HGNC:20222
    See related
    Ensembl:ENSG00000198208 AllianceGenome:HGNC:20222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSKL2
    Summary
    Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in ribosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 4.6), testis (RPKM 3.0) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q24.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74903951..74923260, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69113051..69132361, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75370654..75389963, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene prospero homeobox 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75342793-75343292 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:75348551-75348777 Neighboring gene METTL5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8732 Neighboring gene HNF4 motif-containing MPRA enhancer 140 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75388716-75389487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75389488-75390258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75401143-75401710 Neighboring gene uncharacterized LOC107984690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5938 Neighboring gene placental growth factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8733 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:75431938-75433137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75446625-75447250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75447251-75447876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75447877-75448500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75469302-75469982 Neighboring gene eukaryotic translation initiation factor 2B subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
    2. The DNA sequence and analysis of human chromosome 14. Heilig R, et al. Nature, 2003 Feb 6. PMID 12508121
    3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identified as a pseudokinase and named RSKL2.
      Title: The protein kinase complement of the human genome.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35734, MGC11287

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase-like 1
    NP_001357181.1
    NP_001357182.1
    NP_001357184.1
    NP_001357185.1
    NP_001357186.1
    NP_001357187.1
    NP_113652.2
    XP_011535508.1
    XP_011535509.1
    XP_011535513.1
    XP_011535515.1
    XP_016877169.1
    XP_016877171.1
    XP_016877172.1
    XP_016877173.1
    XP_016877174.1
    XP_016877175.1
    XP_016877177.1
    XP_016877180.1
    XP_024305484.1
    XP_024305485.1
    XP_047287752.1
    XP_047287753.1
    XP_047287754.1
    XP_047287755.1
    XP_047287756.1
    XP_047287757.1
    XP_054232751.1
    XP_054232752.1
    XP_054232753.1
    XP_054232754.1
    XP_054232755.1
    XP_054232756.1
    XP_054232757.1
    XP_054232758.1
    XP_054232759.1
    XP_054232760.1
    XP_054232761.1
    XP_054232762.1
    XP_054232763.1
    XP_054232764.1
    XP_054232765.1
    XP_054232766.1
    XP_054232767.1
    XP_054232768.1
    XP_054232769.1
    XP_054232770.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034007.1 RefSeqGene

      Range
      4183..23492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370252.1 → NP_001357181.1  ribosomal protein S6 kinase-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC006530
      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 508
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    2. NM_001370253.1 → NP_001357182.1  ribosomal protein S6 kinase-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC006530
      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:146 → 499
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    3. NM_001370255.1 → NP_001357184.1  ribosomal protein S6 kinase-like 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC006530
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148 → 305
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001370256.1 → NP_001357185.1  ribosomal protein S6 kinase-like 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC006530
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148 → 307
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001370257.1 → NP_001357186.1  ribosomal protein S6 kinase-like 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC006530
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:131 → 249
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001370258.1 → NP_001357187.1  ribosomal protein S6 kinase-like 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC006530
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:131 → 219
      PKc_like; Protein Kinases, catalytic domain

    7. NM_031464.5 → NP_113652.2  ribosomal protein S6 kinase-like 1 isoform 2

      See identical proteins and their annotated locations for NP_113652.2

      Status: VALIDATED

      Source sequence(s)
      AC006530, AK299846
      Consensus CDS
      CCDS9834.2
      UniProtKB/Swiss-Prot
      A6NGM9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9, Q9Y6S9
      UniProtKB/TrEMBL
      B4DSP6
      Related
      ENSP00000450567.1, ENST00000557413.6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 539
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    RNA

    1. NR_163404.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006530

    2. NR_163405.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006530

    3. NR_163406.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006530

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      74903951..74923260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431797.1 → XP_047287753.1  ribosomal protein S6 kinase-like 1 isoform X6

    2. XM_017021682.2 → XP_016877171.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 539
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    3. XM_047431796.1 → XP_047287752.1  ribosomal protein S6 kinase-like 1 isoform X2

    4. XM_024449717.2 → XP_024305485.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 539
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    5. XM_011537206.4 → XP_011535508.1  ribosomal protein S6 kinase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011535508.1

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 555
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    6. XM_011537213.4 → XP_011535515.1  ribosomal protein S6 kinase-like 1 isoform X7

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:131 → 492
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    7. XM_017021691.3 → XP_016877180.1  ribosomal protein S6 kinase-like 1 isoform X14

    8. XM_047431800.1 → XP_047287756.1  ribosomal protein S6 kinase-like 1 isoform X12

    9. XM_011537211.4 → XP_011535513.1  ribosomal protein S6 kinase-like 1 isoform X6

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:131 → 508
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    10. XM_047431801.1 → XP_047287757.1  ribosomal protein S6 kinase-like 1 isoform X13

    11. XM_024449716.2 → XP_024305484.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 539
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    12. XM_017021688.3 → XP_016877177.1  ribosomal protein S6 kinase-like 1 isoform X11

      Conserved Domains (3) summary
      smart00220
      Location:177 → 353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148 → 353
      PKc_like; Protein Kinases, catalytic domain

    13. XM_017021683.3 → XP_016877172.1  ribosomal protein S6 kinase-like 1 isoform X3

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148 → 525
      PKc_like; Protein Kinases, catalytic domain

    14. XM_017021684.3 → XP_016877173.1  ribosomal protein S6 kinase-like 1 isoform X4

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 523
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    15. XM_017021680.3 → XP_016877169.1  ribosomal protein S6 kinase-like 1 isoform X1

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 555
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    16. XM_011537207.3 → XP_011535509.1  ribosomal protein S6 kinase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011535509.1

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 555
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    17. XM_047431799.1 → XP_047287755.1  ribosomal protein S6 kinase-like 1 isoform X9

      Related
      ENSP00000450660.1, ENST00000555009.5

    18. XM_047431798.1 → XP_047287754.1  ribosomal protein S6 kinase-like 1 isoform X8

    19. XM_017021685.3 → XP_016877174.1  ribosomal protein S6 kinase-like 1 isoform X5

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148 → 555
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    20. XM_017021686.3 → XP_016877175.1  ribosomal protein S6 kinase-like 1 isoform X10

      Conserved Domains (2) summary
      cd02677
      Location:48 → 122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148 → 439
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      69113051..69132361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376787.1 → XP_054232762.1  ribosomal protein S6 kinase-like 1 isoform X6

    2. XM_054376781.1 → XP_054232756.1  ribosomal protein S6 kinase-like 1 isoform X2

    3. XM_054376782.1 → XP_054232757.1  ribosomal protein S6 kinase-like 1 isoform X2

    4. XM_054376780.1 → XP_054232755.1  ribosomal protein S6 kinase-like 1 isoform X2

    5. XM_054376778.1 → XP_054232753.1  ribosomal protein S6 kinase-like 1 isoform X1

    6. XM_054376788.1 → XP_054232763.1  ribosomal protein S6 kinase-like 1 isoform X7

    7. XM_054376795.1 → XP_054232770.1  ribosomal protein S6 kinase-like 1 isoform X14

    8. XM_054376793.1 → XP_054232768.1  ribosomal protein S6 kinase-like 1 isoform X12

    9. XM_054376786.1 → XP_054232761.1  ribosomal protein S6 kinase-like 1 isoform X6

    10. XM_054376794.1 → XP_054232769.1  ribosomal protein S6 kinase-like 1 isoform X13

    11. XM_054376779.1 → XP_054232754.1  ribosomal protein S6 kinase-like 1 isoform X2

    12. XM_054376792.1 → XP_054232767.1  ribosomal protein S6 kinase-like 1 isoform X11

    13. XM_054376783.1 → XP_054232758.1  ribosomal protein S6 kinase-like 1 isoform X3

    14. XM_054376784.1 → XP_054232759.1  ribosomal protein S6 kinase-like 1 isoform X4

    15. XM_054376776.1 → XP_054232751.1  ribosomal protein S6 kinase-like 1 isoform X1

    16. XM_054376777.1 → XP_054232752.1  ribosomal protein S6 kinase-like 1 isoform X1

    17. XM_054376790.1 → XP_054232765.1  ribosomal protein S6 kinase-like 1 isoform X9

    18. XM_054376789.1 → XP_054232764.1  ribosomal protein S6 kinase-like 1 isoform X8

    19. XM_054376785.1 → XP_054232760.1  ribosomal protein S6 kinase-like 1 isoform X5

    20. XM_054376791.1 → XP_054232766.1  ribosomal protein S6 kinase-like 1 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6S9.1 GenPept UniProtKB/Swiss-Prot:Q9Y6S9

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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