S1PR1 sphingosine-1-phosphate receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: S1PR1provided by HGNC
Official Full Name: sphingosine-1-phosphate receptor 1provided by HGNC
Primary source: HGNC:HGNC:3165
See related: Ensembl:ENSG00000170989 MIM:601974; AllianceGenome:HGNC:3165
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362
Summary: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression: Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p21.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (101236899..101242313)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (101085760..101091176)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (101702455..101707869)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition.
Title: Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition.
S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes.
Title: S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes.
S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway.
Title: S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway.
CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus.
Title: CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus.
HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus.
Title: HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus.
Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.
Title: Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.
Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function.
Title: Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function.
S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720.
Title: S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720.
Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients.
Title: Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients.
Sphingosine-1-phosphate receptor modulation improves neurogenesis and functional recovery after stroke.
Title: Sphingosine-1-phosphate receptor modulation improves neurogenesis and functional recovery after stroke.

Submit: New GeneRIF Correction See all GeneRIFs (190)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif downregulates the expression of sphingosine-1-phosphate receptor 1 (S1PR1) in Vif-expression T cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC333404P1 (e-PCR)
- UniSTS:273161

EDG1 (e-PCR)
- UniSTS:479761

D1S1774E (e-PCR)
- UniSTS:150552

RH92741 (e-PCR)
- UniSTS:92701

SHGC-75229 (e-PCR)
- UniSTS:80939

EDG1 (e-PCR)
- UniSTS:503862

EDG1 (e-PCR)
- UniSTS:278327

RH69118 (e-PCR)
- UniSTS:58685

D1S3362 (e-PCR)
- UniSTS:58945

AL009411 (e-PCR)
- UniSTS:67145

EDG1 (e-PCR)
- UniSTS:263017

EDG1 (e-PCR)
- UniSTS:266357

D1S1917E (e-PCR)
- UniSTS:151211

D1S2185 (e-PCR)
- UniSTS:78589

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sphingolipid binding	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle tissue growth involved in heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in heart trabecula morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of bone resorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in transmission of nerve impulse	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 1

Names: S1P receptor 1; S1P receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016181.1 RefSeqGene

Range

5271..9770

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001320730.2 → NP_001307659.1 sphingosine 1-phosphate receptor 1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL109741, BP236900

Consensus CDS

CCDS777.1

UniProtKB/Swiss-Prot

D3DT66, P21453, Q9BYY4, Q9NYN8

UniProtKB/TrEMBL

Q7L853

Conserved Domains (1) summary

cd15346
Location:46 → 322

7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001400.5 → NP_001391.2 sphingosine 1-phosphate receptor 1

See identical proteins and their annotated locations for NP_001391.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL109741

Consensus CDS

CCDS777.1

UniProtKB/Swiss-Prot

D3DT66, P21453, Q9BYY4, Q9NYN8

UniProtKB/TrEMBL

Q7L853

Related

ENSP00000305416.6, ENST00000305352.7

Conserved Domains (1) summary

cd15346
Location:46 → 322

7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors