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    ZNF429 zinc finger protein 429 [ Homo sapiens (human) ]

    Gene ID: 353088, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF429provided by HGNC
    Official Full Name
    zinc finger protein 429provided by HGNC
    Primary source
    HGNC:HGNC:20817
    See related
    Ensembl:ENSG00000197013 AllianceGenome:HGNC:20817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.7), ovary (RPKM 1.8) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21505602..21540668)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21644168..21679216)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21688404..21723470)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372321 Neighboring gene MPRA-validated peak3411 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21643213-21643712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21646023-21646921 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21657297-21657950 Neighboring gene long intergenic non-protein coding RNA 664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21688185-21688787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21688788-21689389 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21694415-21695021 Neighboring gene BCL2 interacting protein 3 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21734180-21734961 Neighboring gene uncharacterized LOC124904670 Neighboring gene uncharacterized LOC101929007 Neighboring gene uncharacterized LOC105372323

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study of acute post-surgical pain in humans. Kim H, et al. Pharmacogenomics, 2009 Feb. PMID 19207018, Free PMC Article
    2. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of acute post-surgical pain in humans.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 429

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001415.4 → NP_001001415.2  zinc finger protein 429 isoform a

      See identical proteins and their annotated locations for NP_001001415.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC010615, BM981242, DA533537
      Consensus CDS
      CCDS42537.1
      UniProtKB/Swiss-Prot
      A6NLV7, Q86V71, Q9BZE6
      Related
      ENSP00000351280.3, ENST00000358491.9
      Conserved Domains (5) summary
      smart00349
      Location:4 → 63
      KRAB; krueppel associated box
      COG5048
      Location:229 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:427 → 447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:467 → 492
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001346912.2 → NP_001333841.1  zinc finger protein 429 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC010615

    3. NM_001346913.2 → NP_001333842.1  zinc finger protein 429 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
      Source sequence(s)
      AC010615

    4. NM_001346914.2 → NP_001333843.1  zinc finger protein 429 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
      Source sequence(s)
      AC010615

    5. NM_001346915.2 → NP_001333844.1  zinc finger protein 429 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
      Source sequence(s)
      AC010615

    6. NM_001346916.2 → NP_001333845.1  zinc finger protein 429 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC010615

    RNA

    1. NR_144522.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010615, KC877715

    2. NR_144523.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010615, KC877715

    3. NR_144524.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010615, KC877715

    4. NR_144525.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010615
      Related
      ENST00000598747.1

    5. NR_144526.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010615
      Related
      ENST00000597556.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      21505602..21540668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438765.1 → XP_047294721.1  zinc finger protein 429 isoform X1

    2. XM_017026748.3 → XP_016882237.1  zinc finger protein 429 isoform X1

    3. XM_017026752.2 → XP_016882241.1  zinc finger protein 429 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      21644168..21679216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320855.1 → XP_054176830.1  zinc finger protein 429 isoform X1

    2. XM_054320857.1 → XP_054176832.1  zinc finger protein 429 isoform X1

    3. XM_054320856.1 → XP_054176831.1  zinc finger protein 429 isoform X1

    4. XM_054320858.1 → XP_054176833.1  zinc finger protein 429 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86V71.2 GenPept UniProtKB/Swiss-Prot:Q86V71

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