APOL6 apolipoprotein L6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: APOL6provided by HGNC
Official Full Name: apolipoprotein L6provided by HGNC
Primary source: HGNC:HGNC:14870
See related: Ensembl:ENSG00000221963 MIM:607256; AllianceGenome:HGNC:14870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APOLVI; APOL-VI
Summary: This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 14.3), liver (RPKM 13.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q12.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (35648446..35668404)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (36108171..36128130)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (36044493..36064451)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

APOL6 has a high ranking for tumor aggressiveness, and interacts with genes in the STAT pathway, and with genes annotated as being part of the defense response, and the interferon signaling pathway.
Title: Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations.
High APOL6 expression is associated with obesity and obesity-related cancers.
Title: miR-10b-5p regulates 3T3-L1 cells differentiation by targeting Apol6.
Polymorphisms in FABP2 and APOL6, located at the predicted miRNAs binding sites, are identified to contribute to susceptibility to MetS in the Chinese Han population.
Title: Polymorphisms in lipid metabolism related miRNA binding sites and risk of metabolic syndrome.
results suggest that ApoL6 regulates both apoptosis and autophagy in SMCs. IFNgamma-initiated, ApoL6-induced apoptosis in vascular cells may be an important factor causing plaque instability
Title: Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function.
Apolipoprotein l6 is a novel proapoptotic Bcl-2 homology 3-only protein that induces mitochondria-mediated apoptosis in cancer cells
Title: Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells.
APOL6 has been found only in humans
Title: The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Infectious wild type HIV-1 production is restricted by 293T cells over-expressing APOL6	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of apolipoprotein L, 6 (APOL6) in U-937 macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D22S977E (e-PCR)
- UniSTS:150791

APOL6_715 (e-PCR)
- UniSTS:277003

D10S275 (e-PCR)
- UniSTS:147992

WI-19821 (e-PCR)
- UniSTS:82906

Clone Names

FLJ38562, FLJ90164, MGC57495, DKFZp667M075

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: apolipoprotein L6

Names: apolipoprotein L, 6; apolipoprotein L-VI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.