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    RPS15A ribosomal protein S15a [ Homo sapiens (human) ]

    Gene ID: 6210, updated on 5-May-2024

    Summary

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    Official Symbol
    RPS15Aprovided by HGNC
    Official Full Name
    ribosomal protein S15aprovided by HGNC
    Primary source
    HGNC:HGNC:10389
    See related
    Ensembl:ENSG00000134419 MIM:603674; AllianceGenome:HGNC:10389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    uS8; S15a; DBA20
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 1052.3), bone marrow (RPKM 811.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    16p12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (18781295..18790334, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (18717732..18726769, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (18792617..18801656, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10538 Neighboring gene ATP binding cassette subfamily C member 6 pseudogene 1 Neighboring gene uncharacterized LOC124903655 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:18800609-18801326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10521 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 1 Neighboring gene SMG1 nonsense mediated mRNA decay associated PI3K related kinase Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1. Wan BS, et al. Eur Rev Med Pharmacol Sci, 2021 Jun. PMID 34156695
    2. Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1. Kong L, et al. J Cell Biochem, 2020 Jan. PMID 31535410
    3. RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway. Liu C, et al. J Cell Mol Med, 2019 Mar. PMID 30661291, Free PMC Article
    4. Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo. Liang J, et al. Mol Med Rep, 2019 Feb. PMID 30569143, Free PMC Article
    5. RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer. Shi D, et al. Yonsei Med J, 2018 Dec. PMID 30450850, Free PMC Article

    See all (204) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A.
      Title: MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A.
    2. FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.
      Title: FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.
    3. Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.
      Title: Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.
    4. MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/beta-catenin signalling via targeting of RPS15A.
      Title: MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/β-catenin signalling via targeting of RPS15A.
    5. Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.
      Title: Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.
    6. Ribosomal protein S15a (RPS15A) is up-regulated in gastric cancer (GC) patients and associated with poor prognosis.
      Title: RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway.
    7. miR-29a-3p inhibits CRC cell function possibly by targeting RPS15A
      Title: Downregulation of RPS15A by miR-29a-3p attenuates cell proliferation in colorectal carcinoma.
    8. A preliminary experimental basis for RPS15A as a novel oncogene and potential therapeutic target in RCC.
      Title: Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo.
    9. The present study found RPS15a expression to be higher in gastric tumors and its silencing in gastric cancer cells to inhibit the proliferation, growth, and migration thereof. Accordingly, RPS15a may be considered as a potential therapeutic target in gastric cancer.
      Title: RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer.
    10. High RPS15A expression is associated with angiogenesis in hepatocellular carcinoma.
      Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Diamond-Blackfan anemia 20
    MedGen: C5193022 OMIM: 618313 GeneReviews: Diamond-Blackfan Anemia
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27457, MGC111208

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit HDA PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS8
    Names
    40S ribosomal protein S15a
    up-regulated by HBV X protein
    NP_001010.2
    NP_001025180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001019.5 → NP_001010.2  small ribosomal subunit protein uS8

      See identical proteins and their annotated locations for NP_001010.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is the longest transcript and utilizes an alternate splice site on the 5'-terminal exon, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC138811, BC001697, BF678907
      Consensus CDS
      CCDS10571.1
      UniProtKB/Swiss-Prot
      P39027, P39031, P62244, Q3MHD9, Q8C023, Q9BV24
      UniProtKB/TrEMBL
      A8K7H3, B2R4W8
      Related
      ENSP00000318646.4, ENST00000322989.8
      Conserved Domains (1) summary
      PTZ00158
      Location:1 → 130
      PTZ00158; 40S ribosomal protein S15A; Provisional

    2. NM_001030009.2 → NP_001025180.1  small ribosomal subunit protein uS8

      See identical proteins and their annotated locations for NP_001025180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and utilizes an alternate splice site on the 5'-terminal exon, compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC138811, AK130967, BC030569
      Consensus CDS
      CCDS10571.1
      UniProtKB/Swiss-Prot
      P39027, P39031, P62244, Q3MHD9, Q8C023, Q9BV24
      UniProtKB/TrEMBL
      A8K7H3, B2R4W8
      Related
      ENSP00000457000.1, ENST00000563390.5
      Conserved Domains (1) summary
      PTZ00158
      Location:1 → 130
      PTZ00158; 40S ribosomal protein S15A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      18781295..18790334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      18717732..18726769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62244.2 GenPept UniProtKB/Swiss-Prot:P62244

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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