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    TUT4 terminal uridylyl transferase 4 [ Homo sapiens (human) ]

    Gene ID: 23318, updated on 7-Apr-2024

    Summary

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    Official Symbol
    TUT4provided by HGNC
    Official Full Name
    terminal uridylyl transferase 4provided by HGNC
    Primary source
    HGNC:HGNC:28981
    See related
    Ensembl:ENSG00000134744 MIM:613692; AllianceGenome:HGNC:28981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAPD3; TENT3A; ZCCHC11
    Summary
    Enables RNA uridylyltransferase activity. Involved in RNA metabolic process; negative regulation of transposition, RNA-mediated; and stem cell population maintenance. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleolus. Implicated in liver benign neoplasm. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 11.1), thyroid (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p32.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52423275..52553463, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52304743..52434560, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (52888947..53018764, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:52869594-52870793 Neighboring gene uncharacterized LOC124904850 Neighboring gene Sharpr-MPRA regulatory region 15542 Neighboring gene pre-mRNA processing factor 38A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1032 Neighboring gene MPRA-validated peak227 silencer Neighboring gene MPRA-validated peak228 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:52963547-52964066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:52964067-52964586 Neighboring gene uncharacterized LOC105378723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53036969-53037469 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 7 Neighboring gene glutathione peroxidase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kinetic and Mechanistic Studies of the Terminal Uridylyltransferase, Zcchc11 (TUT4). Stein RL, et al. Biochemistry, 2022 Aug 2. PMID 35797480
    2. Identification of small molecule inhibitors of Zcchc11 TUTase activity. Lin S, et al. RNA Biol, 2015. PMID 26114892, Free PMC Article
    3. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity. Blahna MT, et al. J Biol Chem, 2011 Dec 9. PMID 22006926, Free PMC Article
    4. Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis. Zhang P, et al. Cells, 2022 Nov 23. PMID 36497000, Free PMC Article
    5. RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type. Medhi R, et al. RNA, 2022 Mar. PMID 34949722, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.
      Title: Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.
    2. TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
      Title: TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
    3. RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
      Title: RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
    4. Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11.
      Title: Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11.
    5. This tail-U-mediated repression (TUMR) is abolished in cells lacking the uridylation enzymes TUT4 and TUT7, indicating that uridylation alters miRNA function by modulating target recognition. We identified a set of non-canonical targets in human cells that are specifically regulated by uridylated miR-27a.
      Title: 3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
    6. Uridylation by TUT4, which is enriched in cytoplasmic foci, destabilizes LINE-1 mRNAs.
      Title: Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.
    7. The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
      Title: Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
    8. For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s
      Title: Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.
    9. Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase) Zcchc11 (TUT4) activity.
      Title: Identification of small molecule inhibitors of Zcchc11 TUTase activity.
    10. Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
      Title: Uridylation by TUT4 and TUT7 marks mRNA for degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42878, DKFZp779C1943

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA 3' uridylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in RNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in histone mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in miRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oocyte maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in polyuridylation-dependent mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pre-miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrotransposon silencing by mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    terminal uridylyltransferase 4
    Names
    PAP associated domain containing 3
    TUTase 4
    zinc finger CCHC domain-containing protein 11
    zinc finger CCHC-type containing 11
    zinc finger, CCHC domain containing 11
    NP_001009881.1
    NP_056084.1
    XP_005270733.1
    XP_005270735.1
    XP_005270736.1
    XP_005270737.1
    XP_005270738.1
    XP_005270739.1
    XP_011539399.1
    XP_011539401.1
    XP_016856292.1
    XP_016856293.1
    XP_016856294.1
    XP_016856295.1
    XP_016856296.1
    XP_016856297.1
    XP_016856299.1
    XP_016856307.1
    XP_047272280.1
    XP_047272281.1
    XP_047272282.1
    XP_047272283.1
    XP_047272285.1
    XP_047272286.1
    XP_047272288.1
    XP_047272290.1
    XP_047272295.1
    XP_047272296.1
    XP_047272303.1
    XP_047272305.1
    XP_047272306.1
    XP_047272307.1
    XP_047272311.1
    XP_047272320.1
    XP_047272325.1
    XP_047272327.1
    XP_047272336.1
    XP_047272337.1
    XP_047272344.1
    XP_047272345.1
    XP_047272348.1
    XP_047272350.1
    XP_047272354.1
    XP_047272362.1
    XP_047272365.1
    XP_047272367.1
    XP_047272369.1
    XP_047272372.1
    XP_047272373.1
    XP_047272377.1
    XP_047272384.1
    XP_054191485.1
    XP_054191486.1
    XP_054191487.1
    XP_054191488.1
    XP_054191489.1
    XP_054191490.1
    XP_054191491.1
    XP_054191492.1
    XP_054191493.1
    XP_054191494.1
    XP_054191495.1
    XP_054191496.1
    XP_054191497.1
    XP_054191498.1
    XP_054191499.1
    XP_054191500.1
    XP_054191501.1
    XP_054191502.1
    XP_054191503.1
    XP_054191504.1
    XP_054191505.1
    XP_054191506.1
    XP_054191507.1
    XP_054191508.1
    XP_054191509.1
    XP_054191510.1
    XP_054191511.1
    XP_054191512.1
    XP_054191513.1
    XP_054191514.1
    XP_054191515.1
    XP_054191516.1
    XP_054191517.1
    XP_054191518.1
    XP_054191519.1
    XP_054191520.1
    XP_054191521.1
    XP_054191522.1
    XP_054191523.1
    XP_054191524.1
    XP_054191525.1
    XP_054191526.1
    XP_054191527.1
    XP_054191528.1
    XP_054191529.1
    XP_054191530.1
    XP_054191531.1
    XP_054191532.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009881.3 → NP_001009881.1  terminal uridylyltransferase 4 isoform a

      See identical proteins and their annotated locations for NP_001009881.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK025698, AL138849, AL591167, BC131734, DA748708
      Consensus CDS
      CCDS30715.1
      UniProtKB/TrEMBL
      A0A0C4DFM7
      Related
      ENSP00000257177.4, ENST00000257177.9
      Conserved Domains (6) summary
      cd05402
      Location:971 → 1089
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:628 → 677
      PAP_assoc; Cid1 family poly A polymerase
      cl00325
      Location:97 → 199
      Ribosomal_L4; Ribosomal protein L4/L1 family
      cl25764
      Location:1395 → 1620
      PAT1; Topoisomerase II-associated protein PAT1
      cl26705
      Location:1280 → 1375
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      cl27230
      Location:929 → 1261
      PAP_assoc; Cid1 family poly A polymerase

    2. NM_015269.2 → NP_056084.1  terminal uridylyltransferase 4 isoform b

      See identical proteins and their annotated locations for NP_056084.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of a coding exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC035820, D83776, DA748708, R60512
      Consensus CDS
      CCDS30716.1
      UniProtKB/Swiss-Prot
      A2RRP0, B7Z8J5, D3DQ35, Q12764, Q5TAX2, Q5TAX3, Q5TAX4, Q86XZ3
      Related
      ENSP00000360599.3, ENST00000371544.7
      Conserved Domains (4) summary
      cd05402
      Location:971 → 1089
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:1184 → 1237
      PAP_assoc; Cid1 family poly A polymerase
      pfam09786
      Location:1374 → 1515
      CytochromB561_N; Cytochrome B561, N terminal
      pfam14650
      Location:1422 → 1483
      FAM75; FAM75 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      52423275..52553463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000804.3 → XP_016856293.1  terminal uridylyltransferase 4 isoform X16

    2. XM_047416324.1 → XP_047272280.1  terminal uridylyltransferase 4 isoform X3

    3. XM_047416327.1 → XP_047272283.1  terminal uridylyltransferase 4 isoform X6

    4. XM_005270678.3 → XP_005270735.1  terminal uridylyltransferase 4 isoform X2

      Conserved Domains (5) summary
      cd05402
      Location:971 → 1089
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:1184 → 1237
      PAP_assoc; Cid1 family poly A polymerase
      pfam07223
      Location:1382 → 1649
      DUF1421; Protein of unknown function (DUF1421)
      pfam09786
      Location:1374 → 1515
      CytochromB561_N; Cytochrome B561, N terminal
      pfam14650
      Location:1422 → 1483
      FAM75; FAM75 family

    5. XM_047416326.1 → XP_047272282.1  terminal uridylyltransferase 4 isoform X5

      UniProtKB/Swiss-Prot
      A2RRP0, B7Z8J5, D3DQ35, Q12764, Q5TAX2, Q5TAX3, Q5TAX4, Q86XZ3

    6. XM_011541097.2 → XP_011539399.1  terminal uridylyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_011539399.1

      Conserved Domains (7) summary
      cd05402
      Location:971 → 1089
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      PTZ00368
      Location:1280 → 1375
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      PRK14907
      Location:97 → 199
      rplD; 50S ribosomal protein L4; Provisional
      PHA03247
      Location:1406 → 1592
      PHA03247; large tegument protein UL36; Provisional
      COG5260
      Location:929 → 1261
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:628 → 677
      PAP_assoc; Cid1 family poly A polymerase
      pfam19088
      Location:265 → 600
      TUTase; TUTase nucleotidyltransferase domain

    7. XM_047416325.1 → XP_047272281.1  terminal uridylyltransferase 4 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DFM7

    8. XM_047416416.1 → XP_047272372.1  terminal uridylyltransferase 4 isoform X42

    9. XM_047416421.1 → XP_047272377.1  terminal uridylyltransferase 4 isoform X44

    10. XM_047416417.1 → XP_047272373.1  terminal uridylyltransferase 4 isoform X43

    11. XM_017000808.2 → XP_016856297.1  terminal uridylyltransferase 4 isoform X36

    12. XM_017000810.3 → XP_016856299.1  terminal uridylyltransferase 4 isoform X40

    13. XM_047416409.1 → XP_047272365.1  terminal uridylyltransferase 4 isoform X38

    14. XM_005270682.3 → XP_005270739.1  terminal uridylyltransferase 4 isoform X33

      Conserved Domains (6) summary
      cd05402
      Location:860 → 978
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      PTZ00368
      Location:1169 → 1264
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      pfam03828
      Location:1073 → 1126
      PAP_assoc; Cid1 family poly A polymerase
      pfam07223
      Location:1272 → 1539
      DUF1421; Protein of unknown function (DUF1421)
      pfam09786
      Location:1264 → 1405
      CytochromB561_N; Cytochrome B561, N terminal
      pfam14650
      Location:1312 → 1373
      FAM75; FAM75 family

    15. XM_047416413.1 → XP_047272369.1  terminal uridylyltransferase 4 isoform X41

    16. XM_047416389.1 → XP_047272345.1  terminal uridylyltransferase 4 isoform X31

    17. XM_011541099.2 → XP_011539401.1  terminal uridylyltransferase 4 isoform X29

      Conserved Domains (6) summary
      cd05402
      Location:873 → 991
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      PTZ00368
      Location:1182 → 1277
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      pfam03828
      Location:1086 → 1139
      PAP_assoc; Cid1 family poly A polymerase
      pfam07223
      Location:1285 → 1552
      DUF1421; Protein of unknown function (DUF1421)
      pfam09786
      Location:1277 → 1418
      CytochromB561_N; Cytochrome B561, N terminal
      pfam14650
      Location:1325 → 1386
      FAM75; FAM75 family

    18. XM_047416380.1 → XP_047272336.1  terminal uridylyltransferase 4 isoform X26

    19. XM_047416371.1 → XP_047272327.1  terminal uridylyltransferase 4 isoform X24

    20. XM_047416355.1 → XP_047272311.1  terminal uridylyltransferase 4 isoform X21

    21. XM_047416364.1 → XP_047272320.1  terminal uridylyltransferase 4 isoform X22

    22. XM_017000803.2 → XP_016856292.1  terminal uridylyltransferase 4 isoform X9

    23. XM_047416329.1 → XP_047272285.1  terminal uridylyltransferase 4 isoform X7

    24. XM_047416332.1 → XP_047272288.1  terminal uridylyltransferase 4 isoform X10

    25. XM_047416394.1 → XP_047272350.1  terminal uridylyltransferase 4 isoform X34

    26. XM_047416388.1 → XP_047272344.1  terminal uridylyltransferase 4 isoform X30

    27. XM_047416411.1 → XP_047272367.1  terminal uridylyltransferase 4 isoform X39

    28. XM_047416406.1 → XP_047272362.1  terminal uridylyltransferase 4 isoform X37

    29. XM_047416392.1 → XP_047272348.1  terminal uridylyltransferase 4 isoform X32

    30. XM_047416398.1 → XP_047272354.1  terminal uridylyltransferase 4 isoform X35

    31. XM_017000806.2 → XP_016856295.1  terminal uridylyltransferase 4 isoform X25

    32. XM_017000807.3 → XP_016856296.1  terminal uridylyltransferase 4 isoform X28

    33. XM_047416369.1 → XP_047272325.1  terminal uridylyltransferase 4 isoform X23

    34. XM_047416381.1 → XP_047272337.1  terminal uridylyltransferase 4 isoform X27

    35. XM_047416334.1 → XP_047272290.1  terminal uridylyltransferase 4 isoform X11

    36. XM_047416349.1 → XP_047272305.1  terminal uridylyltransferase 4 isoform X17

    37. XM_047416340.1 → XP_047272296.1  terminal uridylyltransferase 4 isoform X13

    38. XM_047416330.1 → XP_047272286.1  terminal uridylyltransferase 4 isoform X8

    39. XM_047416339.1 → XP_047272295.1  terminal uridylyltransferase 4 isoform X12

    40. XM_047416350.1 → XP_047272306.1  terminal uridylyltransferase 4 isoform X18

    41. XM_017000805.3 → XP_016856294.1  terminal uridylyltransferase 4 isoform X20

    42. XM_047416347.1 → XP_047272303.1  terminal uridylyltransferase 4 isoform X15

    43. XM_047416351.1 → XP_047272307.1  terminal uridylyltransferase 4 isoform X19

    44. XM_005270681.3 → XP_005270738.1  terminal uridylyltransferase 4 isoform X14

      Conserved Domains (6) summary
      cd05402
      Location:971 → 1089
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      PTZ00368
      Location:1242 → 1337
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      pfam03828
      Location:1146 → 1199
      PAP_assoc; Cid1 family poly A polymerase
      pfam07223
      Location:1345 → 1612
      DUF1421; Protein of unknown function (DUF1421)
      pfam09786
      Location:1337 → 1478
      CytochromB561_N; Cytochrome B561, N terminal
      pfam14650
      Location:1385 → 1446
      FAM75; FAM75 family

    45. XM_005270679.3 → XP_005270736.1  terminal uridylyltransferase 4 isoform X3

      Conserved Domains (6) summary
      cd05402
      Location:971 → 1089
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      PTZ00368
      Location:1280 → 1370
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      pfam03828
      Location:1184 → 1237
      PAP_assoc; Cid1 family poly A polymerase
      pfam07223
      Location:1378 → 1645
      DUF1421; Protein of unknown function (DUF1421)
      pfam09786
      Location:1370 → 1511
      CytochromB561_N; Cytochrome B561, N terminal
      pfam14650
      Location:1418 → 1479
      FAM75; FAM75 family

    46. XM_005270680.4 → XP_005270737.1  terminal uridylyltransferase 4 isoform X6

      See identical proteins and their annotated locations for XP_005270737.1

      Conserved Domains (5) summary
      cd05402
      Location:971 → 1089
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      PTZ00368
      Location:1280 → 1370
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      pfam03828
      Location:1184 → 1237
      PAP_assoc; Cid1 family poly A polymerase
      pfam09786
      Location:1370 → 1511
      CytochromB561_N; Cytochrome B561, N terminal
      pfam14650
      Location:1418 → 1479
      FAM75; FAM75 family

    47. XM_005270676.3 → XP_005270733.1  terminal uridylyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_005270733.1

      Conserved Domains (7) summary
      cd05402
      Location:971 → 1089
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      PTZ00368
      Location:1280 → 1375
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      PRK14907
      Location:97 → 199
      rplD; 50S ribosomal protein L4; Provisional
      PHA03247
      Location:1406 → 1592
      PHA03247; large tegument protein UL36; Provisional
      COG5260
      Location:929 → 1261
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:628 → 677
      PAP_assoc; Cid1 family poly A polymerase
      pfam19088
      Location:265 → 600
      TUTase; TUTase nucleotidyltransferase domain

    48. XM_047416428.1 → XP_047272384.1  terminal uridylyltransferase 4 isoform X46

    49. XM_017000818.2 → XP_016856307.1  terminal uridylyltransferase 4 isoform X45

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      52304743..52434560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335554.1 → XP_054191529.1  terminal uridylyltransferase 4 isoform X44

    2. XM_054335553.1 → XP_054191528.1  terminal uridylyltransferase 4 isoform X43

    3. XM_054335551.1 → XP_054191526.1  terminal uridylyltransferase 4 isoform X40

    4. XM_054335549.1 → XP_054191524.1  terminal uridylyltransferase 4 isoform X38

    5. XM_054335548.1 → XP_054191523.1  terminal uridylyltransferase 4 isoform X52

    6. XM_054335537.1 → XP_054191512.1  terminal uridylyltransferase 4 isoform X26

    7. XM_054335535.1 → XP_054191510.1  terminal uridylyltransferase 4 isoform X24

    8. XM_054335533.1 → XP_054191508.1  terminal uridylyltransferase 4 isoform X22

    9. XM_054335525.1 → XP_054191500.1  terminal uridylyltransferase 4 isoform X16

    10. XM_054335520.1 → XP_054191495.1  terminal uridylyltransferase 4 isoform X48

    11. XM_054335518.1 → XP_054191493.1  terminal uridylyltransferase 4 isoform X10

    12. XM_054335550.1 → XP_054191525.1  terminal uridylyltransferase 4 isoform X39

    13. XM_054335547.1 → XP_054191522.1  terminal uridylyltransferase 4 isoform X37

    14. XM_054335545.1 → XP_054191520.1  terminal uridylyltransferase 4 isoform X35

    15. XM_054335540.1 → XP_054191515.1  terminal uridylyltransferase 4 isoform X28

    16. XM_054335539.1 → XP_054191514.1  terminal uridylyltransferase 4 isoform X27

    17. XM_054335538.1 → XP_054191513.1  terminal uridylyltransferase 4 isoform X51

    18. XM_054335526.1 → XP_054191501.1  terminal uridylyltransferase 4 isoform X17

    19. XM_054335522.1 → XP_054191497.1  terminal uridylyltransferase 4 isoform X13

    20. XM_054335521.1 → XP_054191496.1  terminal uridylyltransferase 4 isoform X12

    21. XM_054335530.1 → XP_054191505.1  terminal uridylyltransferase 4 isoform X20

    22. XM_054335529.1 → XP_054191504.1  terminal uridylyltransferase 4 isoform X19

    23. XM_054335528.1 → XP_054191503.1  terminal uridylyltransferase 4 isoform X49

    24. XM_054335513.1 → XP_054191488.1  terminal uridylyltransferase 4 isoform X6

    25. XM_054335546.1 → XP_054191521.1  terminal uridylyltransferase 4 isoform X36

    26. XM_054335544.1 → XP_054191519.1  terminal uridylyltransferase 4 isoform X33

    27. XM_054335552.1 → XP_054191527.1  terminal uridylyltransferase 4 isoform X41

    28. XM_054335542.1 → XP_054191517.1  terminal uridylyltransferase 4 isoform X31

    29. XM_054335541.1 → XP_054191516.1  terminal uridylyltransferase 4 isoform X29

    30. XM_054335531.1 → XP_054191506.1  terminal uridylyltransferase 4 isoform X21

    31. XM_054335517.1 → XP_054191492.1  terminal uridylyltransferase 4 isoform X9

    32. XM_054335515.1 → XP_054191490.1  terminal uridylyltransferase 4 isoform X7

    33. XM_054335514.1 → XP_054191489.1  terminal uridylyltransferase 4 isoform X47

    34. XM_054335543.1 → XP_054191518.1  terminal uridylyltransferase 4 isoform X32

    35. XM_054335536.1 → XP_054191511.1  terminal uridylyltransferase 4 isoform X25

    36. XM_054335534.1 → XP_054191509.1  terminal uridylyltransferase 4 isoform X23

    37. XM_054335532.1 → XP_054191507.1  terminal uridylyltransferase 4 isoform X50

    38. XM_054335519.1 → XP_054191494.1  terminal uridylyltransferase 4 isoform X11

    39. XM_054335516.1 → XP_054191491.1  terminal uridylyltransferase 4 isoform X8

    40. XM_054335527.1 → XP_054191502.1  terminal uridylyltransferase 4 isoform X18

    41. XM_054335524.1 → XP_054191499.1  terminal uridylyltransferase 4 isoform X15

    42. XM_054335523.1 → XP_054191498.1  terminal uridylyltransferase 4 isoform X14

    43. XM_054335512.1 → XP_054191487.1  terminal uridylyltransferase 4 isoform X3

    44. XM_054335511.1 → XP_054191486.1  terminal uridylyltransferase 4 isoform X2

    45. XM_054335510.1 → XP_054191485.1  terminal uridylyltransferase 4 isoform X1

    46. XM_054335557.1 → XP_054191532.1  terminal uridylyltransferase 4 isoform X46

    47. XM_054335556.1 → XP_054191531.1  terminal uridylyltransferase 4 isoform X45

    48. XM_054335555.1 → XP_054191530.1  terminal uridylyltransferase 4 isoform X53

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009882.1: Suppressed sequence

      Description
      NM_001009882.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TAX3.3 GenPept UniProtKB/Swiss-Prot:Q5TAX3

    Gene LinkOut

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