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    ZNF641 zinc finger protein 641 [ Homo sapiens (human) ]

    Gene ID: 121274, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF641provided by HGNC
    Official Full Name
    zinc finger protein 641provided by HGNC
    Primary source
    HGNC:HGNC:31834
    See related
    Ensembl:ENSG00000167528 MIM:613906; AllianceGenome:HGNC:31834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal (RPKM 5.5), ovary (RPKM 3.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q13.11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48334587..48351246, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48295893..48312553, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48728370..48745029, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369753 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48723521-48724020 Neighboring gene H1.7 linker histone Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48744721-48745457 Neighboring gene olfactory receptor family 5 subfamily BK member 1 pseudogene Neighboring gene olfactory receptor family 5 subfamily BT member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641. Qi X, et al. Biochem Biophys Res Commun, 2006 Jan 27. PMID 16343441
    2. HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription. Yan H, et al. Biochem Biophys Res Commun, 2022 Jun 11. PMID 35427894
    3. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
    5. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription.
      Title: HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31295, DKFZp667D1012

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 641

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172681.2 → NP_001166152.1  zinc finger protein 641 isoform 2

      See identical proteins and their annotated locations for NP_001166152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC024257, AY842285, BC018090
      Consensus CDS
      CCDS53788.1
      UniProtKB/Swiss-Prot
      Q96N77
      Related
      ENSP00000449974.1, ENST00000547026.6
      Conserved Domains (6) summary
      smart00349
      Location:95 → 156
      KRAB; krueppel associated box
      COG5048
      Location:337 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358 → 380
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:95 → 135
      KRAB; KRAB box
      pfam13465
      Location:264 → 289
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001172682.2 → NP_001166153.1  zinc finger protein 641 isoform 3

      See identical proteins and their annotated locations for NP_001166153.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate transcription start site and 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC024257, AK298064, DB445168
      Consensus CDS
      CCDS53787.1
      UniProtKB/Swiss-Prot
      Q96N77
      Related
      ENSP00000394627.3, ENST00000448928.7
      Conserved Domains (4) summary
      COG5048
      Location:328 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:243 → 263
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 280
      zf-H2C2_2; Zinc-finger double domain
      cl25431
      Location:2 → 90
      PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]

    3. NM_001365803.1 → NP_001352732.1  zinc finger protein 641 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC024257
      Consensus CDS
      CCDS53787.1
      Conserved Domains (4) summary
      COG5048
      Location:328 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:243 → 263
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255 → 280
      zf-H2C2_2; Zinc-finger double domain
      cl25431
      Location:2 → 90
      PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]

    4. NM_001365804.1 → NP_001352733.1  zinc finger protein 641 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC024257
      Conserved Domains (2) summary
      PLN03206
      Location:2 → 90
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:95 → 156
      KRAB; krueppel associated box

    5. NM_001365805.1 → NP_001352734.1  zinc finger protein 641 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC024257, DA115635
      Conserved Domains (3) summary
      COG5048
      Location:194 → 273
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:109 → 129
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:121 → 146
      zf-H2C2_2; Zinc-finger double domain

    6. NM_152320.3 → NP_689533.2  zinc finger protein 641 isoform 1

      See identical proteins and their annotated locations for NP_689533.2

      Status: VALIDATED

      Source sequence(s)
      AC024257, AK055857
      Consensus CDS
      CCDS8763.1
      UniProtKB/Swiss-Prot
      B3KS43, B4DNU5, Q8TCQ7, Q8WVE1, Q96N77
      Related
      ENSP00000301042.3, ENST00000301042.7
      Conserved Domains (6) summary
      smart00349
      Location:109 → 170
      KRAB; krueppel associated box
      COG5048
      Location:351 → 430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:109 → 149
      KRAB; KRAB box
      pfam13465
      Location:278 → 303
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      48334587..48351246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268640.6 → XP_005268697.1  zinc finger protein 641 isoform X4

      Conserved Domains (2) summary
      smart00349
      Location:109 → 170
      KRAB; krueppel associated box
      pfam01352
      Location:109 → 149
      KRAB; KRAB box

    2. XM_011537898.3 → XP_011536200.1  zinc finger protein 641 isoform X2

      See identical proteins and their annotated locations for XP_011536200.1

      UniProtKB/Swiss-Prot
      Q96N77
      Conserved Domains (6) summary
      smart00349
      Location:95 → 156
      KRAB; krueppel associated box
      COG5048
      Location:337 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358 → 380
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:95 → 135
      KRAB; KRAB box
      pfam13465
      Location:264 → 289
      zf-H2C2_2; Zinc-finger double domain

    3. XM_005268638.5 → XP_005268695.1  zinc finger protein 641 isoform X2

      See identical proteins and their annotated locations for XP_005268695.1

      UniProtKB/Swiss-Prot
      Q96N77
      Conserved Domains (6) summary
      smart00349
      Location:95 → 156
      KRAB; krueppel associated box
      COG5048
      Location:337 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358 → 380
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:95 → 135
      KRAB; KRAB box
      pfam13465
      Location:264 → 289
      zf-H2C2_2; Zinc-finger double domain

    4. XM_005268637.4 → XP_005268694.1  zinc finger protein 641 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:342 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:269 → 294
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047428287.1 → XP_047284243.1  zinc finger protein 641 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48295893..48312553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371076.1 → XP_054227051.1  zinc finger protein 641 isoform X4

    2. XM_054371073.1 → XP_054227048.1  zinc finger protein 641 isoform X2

    3. XM_054371074.1 → XP_054227049.1  zinc finger protein 641 isoform X2

    4. XM_054371072.1 → XP_054227047.1  zinc finger protein 641 isoform X1

    5. XM_054371075.1 → XP_054227050.1  zinc finger protein 641 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96N77.2 GenPept UniProtKB/Swiss-Prot:Q96N77

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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