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    Rpn2 ribophorin II [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64701, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rpn2provided by RGD
    Official Full Name
    ribophorin IIprovided by RGD
    Primary source
    RGD:62075
    See related
    Ensembl:ENSRNOG00000007492 AllianceGenome:RGD:62075
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ribosome binding activity. Involved in aging and response to xenobiotic stimulus. Located in autophagosome membrane and rough endoplasmic reticulum. Orthologous to human RPN2 (ribophorin II). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 983.5), Kidney (RPKM 788.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpn2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166361955..166409272)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145941787..145989271)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (153398373..153445633)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor like 1 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene uncharacterized LOC134486195 Neighboring gene U7 small nuclear RNA Neighboring gene maestro heat-like repeat family member 8 Neighboring gene uncharacterized LOC134486194 Neighboring gene growth hormone releasing hormone Neighboring gene mannosidase beta like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel flutamide regulated genes in the rat ventral prostate: differential modulation of their expression by castration and flutamide treatments. Limaye AM, et al. Asian J Androl, 2007 Nov. PMID 17968466
    2. Age-associated changes in histology and gene-expression profile in the rat ventral prostate. Lau KM, et al. Lab Invest, 2003 May. PMID 12746483
    3. Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains. Fu J, et al. Eur J Cell Biol, 2000 Apr. PMID 10826490, Free PMC Article
    4. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. Dunn WA Jr. J Cell Biol, 1990 Jun. PMID 2351689, Free PMC Article
    5. Proteins of rough microsomal membranes related to ribosome binding. II. Cross-linking of bound ribosomes to specific membrane proteins exposed at the binding sites. Kreibich G, et al. J Cell Biol, 1978 May. PMID 418074, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
    Names
    RPN-II
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
    ribophorin-2
    NP_113886.1
    XP_006235441.1
    XP_038961743.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031698.1 → NP_113886.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 precursor

      See identical proteins and their annotated locations for NP_113886.1

      Status: PROVISIONAL

      Source sequence(s)
      X55298
      UniProtKB/Swiss-Prot
      P25235, Q6P9X0
      UniProtKB/TrEMBL
      A6JWR7
      Related
      ENSRNOP00000076455.1, ENSRNOT00000118622.1
      Conserved Domains (1) summary
      pfam05817
      Location:9 → 623
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      166361955..166409272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235379.4 → XP_006235441.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      P25235, Q6P9X0
      UniProtKB/TrEMBL
      A0A8L2QVV5, A6JWR7
      Related
      ENSRNOP00000063207.2
      Conserved Domains (1) summary
      pfam05817
      Location:9 → 623
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    2. XM_039105815.1 → XP_038961743.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2

      UniProtKB/TrEMBL
      A6JWR9
      Conserved Domains (1) summary
      pfam05817
      Location:2 → 406
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25235.2 GenPept UniProtKB/Swiss-Prot:P25235

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