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    fosl2 FOS like 2, AP-1 transcription factor subunit [ Danio rerio (zebrafish) ]

    Gene ID: 558921, updated on 27-Mar-2024

    Summary

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    Official Symbol
    fosl2provided by ZNC
    Official Full Name
    FOS like 2, AP-1 transcription factor subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070209-164
    See related
    Ensembl:ENSDARG00000040623 AllianceGenome:ZFIN:ZDB-GENE-070209-164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fra2; wu:fl03b09; wu:fl17h04; xx:fl17h04; zgc:158347
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of cardiac muscle cell myoblast differentiation. Predicted to be active in nucleus. Is expressed in head; presumptive bulbus arteriosus; presumptive cardiac ventricle heart tube; and trunk. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 17
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (41302606..41318554)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (41313748..41329680)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene ribokinase Neighboring gene uncharacterized LOC101885155 Neighboring gene BRISC and BRCA1 A complex member 2 Neighboring gene molybdenum cofactor synthesis 1 Neighboring gene uncharacterized LOC108179794

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Paradoxical Changes Underscore Epigenetic Reprogramming During Adult Zebrafish Extraocular Muscle Regeneration. Tingle CF, et al. Invest Ophthalmol Vis Sci, 2019 Dec 2. PMID 31794598, Free PMC Article
    2. The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Jahangiri L, et al. Development, 2016 Jan 1. PMID 26732840, Free PMC Article
    3. AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration. Beisaw A, et al. Circ Res, 2020 Jun 5. PMID 32312172, Free PMC Article
    4. Hyperactivity, Memory Defects, and Craniofacial Abnormalities in Zebrafish fmr1 Mutant Larvae. Hu J, et al. Behav Genet, 2020 May. PMID 32048109
    5. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Li P, et al. Nature, 2015 Jul 23. PMID 26201599, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.
      Title: Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.
    2. Fos-like antigen 2 (Fosl2), potentiates the rate of myocardial accretion from the zebrafish second heart field.
      Title: The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158347

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cardiac muscle cell myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fos-related antigen 2
    Names
    fos-like antigen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082998.2 → NP_001076467.1  fos-related antigen 2 isoform 1

      See identical proteins and their annotated locations for NP_001076467.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CABZ01079144, CABZ01079145, CABZ01079146
      UniProtKB/TrEMBL
      A0A8M1NDK2, A2RUX8
      Related
      ENSDARP00000059479.4, ENSDART00000059480.5
      Conserved Domains (1) summary
      cd14721
      Location:135 → 188
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    2. NM_001362607.1 → NP_001349536.1  fos-related antigen 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      CABZ01079144, CABZ01079145, CABZ01079146
      UniProtKB/TrEMBL
      A0A8M2BKU3
      Conserved Domains (1) summary
      cd14721
      Location:96 → 149
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      41302606..41318554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173580.4 → XP_005173637.1  fos-related antigen 2 isoform X1

      UniProtKB/TrEMBL
      A2RUX8
      Conserved Domains (1) summary
      cd14721
      Location:135 → 188
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    2. XM_005173581.4 → XP_005173638.1  fos-related antigen 2 isoform X2

      Conserved Domains (1) summary
      cd14721
      Location:96 → 149
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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