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    Cops7b COP9 signalosome subunit 7B [ Mus musculus (house mouse) ]

    Gene ID: 26895, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cops7bprovided by MGI
    Official Full Name
    COP9 signalosome subunit 7Bprovided by MGI
    Primary source
    MGI:MGI:1349388
    See related
    Ensembl:ENSMUSG00000026240 AllianceGenome:MGI:1349388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Wsu66e; E130114M23
    Summary
    Predicted to be involved in protein deneddylation. Predicted to be located in nucleoplasm. Predicted to be part of COP9 signalosome. Is expressed in central nervous system; extraembryonic component; sensory organ; and skeleton. Orthologous to human COPS7B (COP9 signalosome subunit 7B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 20.7), CNS E14 (RPKM 19.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cops7b in Genome Data Viewer
    Location:
    1 C5; 1 43.97 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86510363..86534550)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86582646..86606828)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:88428991-88429292 Neighboring gene prothymosin alpha Neighboring gene phosphodiesterase 6D, cGMP-specific, rod, delta Neighboring gene STARR-positive B cell enhancer ABC_E2552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:88483544-88483727 Neighboring gene STARR-seq mESC enhancer starr_01597 Neighboring gene predicted gene, 41908 Neighboring gene STARR-seq mESC enhancer starr_01598 Neighboring gene natriuretic peptide type C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. Tomoda K, et al. J Biol Chem, 2002 Jan 18. PMID 11704659
    2. Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Deng XW, et al. Trends Genet, 2000 May. PMID 10782111
    3. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Wei N, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707402
    4. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Lyapina S, et al. Science, 2001 May 18. PMID 11337588
    5. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Del Prete D, et al. J Biol Chem, 2016 Aug 12. PMID 27325702, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in COP9 signalosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 7b
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 7b
    COP9 complex S7b
    JAB1-containing signalosome subunit 7b
    SGN7b
    signalosome subunit 7b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360887.1 → NP_001347816.1  COP9 signalosome complex subunit 7b isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC158132
      Consensus CDS
      CCDS15122.1
      UniProtKB/Swiss-Prot
      O88547, Q3TGG7, Q8BV13, Q921G4
      UniProtKB/TrEMBL
      Q3TDL0
      Conserved Domains (1) summary
      smart00088
      Location:88 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    2. NM_001360888.1 → NP_001347817.1  COP9 signalosome complex subunit 7b isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC158132, AK053615
      Conserved Domains (2) summary
      smart00088
      Location:6 → 56
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:45 → 94
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    3. NM_172974.3 → NP_766562.1  COP9 signalosome complex subunit 7b isoform a

      See identical proteins and their annotated locations for NP_766562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC158132, AI121193, AK081309, CN721267
      Consensus CDS
      CCDS15122.1
      UniProtKB/Swiss-Prot
      O88547, Q3TGG7, Q8BV13, Q921G4
      UniProtKB/TrEMBL
      Q3TDL0
      Related
      ENSMUSP00000113587.2, ENSMUST00000121534.8
      Conserved Domains (1) summary
      smart00088
      Location:88 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      86510363..86534550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254496.2 → XP_030110356.1  COP9 signalosome complex subunit 7b isoform X2

      Conserved Domains (2) summary
      smart00088
      Location:6 → 56
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:45 → 94
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    2. XM_006529625.5 → XP_006529688.1  COP9 signalosome complex subunit 7b isoform X1

      UniProtKB/TrEMBL
      Q3TDL0
      Conserved Domains (2) summary
      smart00753
      Location:76 → 165
      PAM; PCI/PINT associated module
      pfam18392
      Location:154 → 203
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    3. XM_036165290.1 → XP_036021183.1  COP9 signalosome complex subunit 7b isoform X2

      Conserved Domains (2) summary
      smart00088
      Location:6 → 56
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:45 → 94
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BV13.1 GenPept UniProtKB/Swiss-Prot:Q8BV13

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