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    SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ Equus caballus (horse) ]

    Gene ID: 100053889, updated on 8-Mar-2024

    Summary

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    Official Symbol
    SOS1provided by VGNC
    Official Full Name
    SOS Ras/Rac guanine nucleotide exchange factor 1provided by VGNC
    Primary source
    VGNC:VGNC:23454
    See related
    Ensembl:ENSECAG00000017604
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 15 NC_009158.3 (59861383..60012311)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 15 NC_009158.2 (58875098..59022147)

    Chromosome 15 - NC_009158.3Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase like 4 Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene MORN repeat containing 2 Neighboring gene DExH-box helicase 57

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    son of sevenless homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009158.3 Reference EquCab3.0 Primary Assembly

      Range
      59861383..60012311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005600032.3 → XP_005600089.1  son of sevenless homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F5PIB2, A0A5F5PZX2
      Related
      ENSECAP00000048245.2, ENSECAT00000077811.2
      Conserved Domains (6) summary
      smart00229
      Location:597 → 741
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:776 → 1015
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00160
      Location:201 → 388
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:439 → 545
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00169
      Location:445 → 546
      PH; PH domain
      cl23907
      Location:97 → 177
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    2. XM_005600033.3 → XP_005600090.1  son of sevenless homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A5F5PZX2, A0A9L0RR69
      Related
      ENSECAP00000066365.1, ENSECAT00000094833.1
      Conserved Domains (6) summary
      smart00229
      Location:597 → 741
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:776 → 1015
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00160
      Location:201 → 388
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:439 → 545
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00169
      Location:445 → 546
      PH; PH domain
      cl23907
      Location:97 → 177
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
    Nucleotide Protein
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