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    Qrsl1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 76563, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Qrsl1provided by MGI
    Official Full Name
    glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1provided by MGI
    Primary source
    MGI:MGI:1923813
    See related
    Ensembl:ENSMUSG00000019863 AllianceGenome:MGI:1923813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GatA; 2700038P16Rik
    Summary
    Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Acts upstream of or within mitochondrial translation and regulation of protein stability. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 9.9), CNS E11.5 (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B2; 10 23.11 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (43750184..43777742, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (43874188..43901742, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933404K13 gene Neighboring gene STARR-positive B cell enhancer ABC_E10604 Neighboring gene STARR-positive B cell enhancer ABC_E1120 Neighboring gene STARR-seq mESC enhancer starr_26522 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_26525 Neighboring gene STARR-seq mESC enhancer starr_26526 Neighboring gene STARR-seq mESC enhancer starr_26527 Neighboring gene STARR-positive B cell enhancer ABC_E6838 Neighboring gene reticulon 4 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_26529 Neighboring gene crystallin beta-gamma domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26530 Neighboring gene predicted gene, 40636

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation in vivo. Echevarría L, et al. Biochem J, 2014 May 15. PMID 24579914
    2. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, et al. Cell Stem Cell, 2019 Apr 4. PMID 30951662
    3. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glutamyl-tRNA(Gln) amidotransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
    Names
    glu-AdT subunit A
    glutaminyl-tRNA synthase-like protein 1
    glutamyl-tRNA(Gln) amidotransferase subunit A homolog
    NP_001074523.1
    XP_036011973.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081054.2 → NP_001074523.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

      See identical proteins and their annotated locations for NP_001074523.1

      Status: VALIDATED

      Source sequence(s)
      AK012351
      Consensus CDS
      CCDS35894.1
      UniProtKB/Swiss-Prot
      Q3TDF6, Q6NS53, Q9CZN8
      Related
      ENSMUSP00000020012.7, ENSMUST00000020012.7
      Conserved Domains (2) summary
      PRK00012
      Location:13 → 491
      gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed
      PRK07488
      Location:5 → 492
      PRK07488; indole acetimide hydrolase; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      43750184..43777742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156080.1 → XP_036011973.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl18951
      Location:13 → 380
      Amidase

    RNA

    1. XR_380090.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZN8.1 GenPept UniProtKB/Swiss-Prot:Q9CZN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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