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    Alg3 ALG3 alpha-1,3- mannosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 208624, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Alg3provided by MGI
    Official Full Name
    ALG3 alpha-1,3- mannosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1098592
    See related
    Ensembl:ENSMUSG00000033809 AllianceGenome:MGI:1098592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    not; D16Ertd36e
    Summary
    Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and retina. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Orthologous to human ALG3 (ALG3 alpha-1,3- mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 3.1), ovary adult (RPKM 2.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A3; 16 12.48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20424208..20429515, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20605458..20610761, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35685 Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene microRNA 1224 Neighboring gene STARR-positive B cell enhancer ABC_E10894 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene Eef1akmt4-endothelin converting enzyme 2 readthrough Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy. Liu P, et al. Cell Mol Life Sci, 2022 Jun 8. PMID 35676564, Free PMC Article
    2. Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes. Pappano WN, et al. Genomics, 1998 Sep 1. PMID 9782094
    3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.
      Title: Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36684

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-1,3-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
    Names
    alpha-1,3-mannosyltransferase ALG3
    asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
    asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)
    asparagine-linked glycosylation protein 3 homolog
    dol-P-Man-dependent alpha(1-3)-mannosyltransferase
    dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
    dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
    not56-like protein
    NP_001344332.1
    NP_001344333.1
    NP_001344334.1
    NP_001344335.1
    NP_666051.2
    XP_006521995.1
    XP_030104881.1
    XP_030104882.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357403.1 → NP_001344332.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087898
      Consensus CDS
      CCDS88898.1
      UniProtKB/TrEMBL
      A0A338P6Y8, A0A338P726
      Related
      ENSMUSP00000156241.2, ENSMUST00000231531.2
      Conserved Domains (1) summary
      pfam05208
      Location:1 → 284
      ALG3; ALG3 protein

    2. NM_001357404.1 → NP_001344333.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: Variants 3, 4, and 5 encode the same isoform (3).
      Source sequence(s)
      AC087898
      Conserved Domains (1) summary
      pfam05208
      Location:1 → 198
      ALG3; ALG3 protein

    3. NM_001357405.1 → NP_001344334.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: Variants 3, 4, and 5 encode the same isoform (3).
      Source sequence(s)
      AC087898
      Conserved Domains (1) summary
      pfam05208
      Location:1 → 198
      ALG3; ALG3 protein

    4. NM_001357406.1 → NP_001344335.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: Variants 3, 4, and 5 encode the same isoform (3).
      Source sequence(s)
      AC087898
      Conserved Domains (1) summary
      pfam05208
      Location:1 → 198
      ALG3; ALG3 protein

    5. NM_145939.3 → NP_666051.2  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 1

      See identical proteins and their annotated locations for NP_666051.2

      Status: VALIDATED

      Source sequence(s)
      AC087898
      Consensus CDS
      CCDS37289.1
      UniProtKB/Swiss-Prot
      E9QKP9, Q8K2A8
      UniProtKB/TrEMBL
      A0A338P6Y8
      Related
      ENSMUSP00000045272.9, ENSMUST00000045918.15
      Conserved Domains (1) summary
      pfam05208
      Location:49 → 406
      ALG3; ALG3 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20424208..20429515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521932.5 → XP_006521995.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A338P6Y8
      Related
      ENSMUSP00000156158.2, ENSMUST00000232458.2
      Conserved Domains (1) summary
      pfam05208
      Location:32 → 371
      ALG3; ALG3 protein

    2. XM_030249022.2 → XP_030104882.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X3

      Conserved Domains (1) summary
      pfam05208
      Location:44 → 247
      ALG3; ALG3 protein

    3. XM_030249021.1 → XP_030104881.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A338P6Y8
      Conserved Domains (1) summary
      pfam05208
      Location:44 → 350
      ALG3; ALG3 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2A8.2 GenPept UniProtKB/Swiss-Prot:Q8K2A8

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